A Case of Fasciola hepatica Infection Mimicking Cholangiocarcinoma and ITS-1 Sequencing of the Worm

Kang, Bong Kyun; Jung, Byung Mun; Lee, Yoon Suk; Hwang, In Kyeom; Lim, Hyemi; Cho, Jaeeun; Hwang, Jin-Hyeok; Chai, Jong Yil

doi:10.3347/kjp.2014.52.2.193

Cited by 25 publications

(18 citation statements)

References 8 publications

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“…The diagnosis of fascioliasis is often delayed due to non-specific radiological and clinical findings. Patients infected with F. hepatica are typically admitted with symptoms of biliary colic, liver abscess, choledocholithiasis, pancreatitis, and compressive symptoms mimicking cholangiocarcinoma (11,12,14). ERCP can be performed for the differential diagnosis and definitive treatment of F. hepatica, thus avoiding further surgery (16).…”

Section: Discussionmentioning

confidence: 99%

“…The utility of ERCP in the treatment of biliary system parasites differs according to parasite type and intervention timing. For example, parasite extraction provides a therapeutic option for F. hepatica if antimicrobial therapy fails to completely eradicate biliary system parasites (10)(11)(12)(13)(14). Moreover, ERCP provides a bridge to safe surgery for Echinococcus granulosus by extracting vesicles from the biliary channel preoperatively.…”

Section: Introductionmentioning

confidence: 99%

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Endoscopic retrograde cholangiopancreatography for biliary system parasites

et al. 2018

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Objective: Endoscopic retrograde cholangiopancreatography may be useful in the diagnosis and management of biliary system parasites. Material and Methods: Investigators retrospectively evaluated patients with biliary system parasites who underwent endoscopic retrograde cholangiopancreatography procedures over an eight-year period. We collected data regarding patient demographics, clinical features, and parasite type. We aimed to determine the utility of endoscopic retrograde cholangiopancreatography as a diagnostic and therapeutic intervention in patients with biliary system parasites. Results: We identified 22 patients with biliary system parasites from a total of 3,450 endoscopic retrograde cholangiopancreatography procedures performed during an eight-year period. Parasite types included Echinococcus granulosus (n=19), Fasciola hepatica (n=2), and Ascaris lumbricoides (n=1). Fifteen patients with liver hydatid cysts underwent endoscopic retrograde cholangiopancreatography prior to surgery due to obstructive jaundice. The endoscopic retrograde cholangiopancreatography procedure enabled definitive treatment without the need for surgery in the remaining two patients. Two patients with fascioliasis underwent endoscopic retrograde cholangiopancreatography due to clinical presentation of cholangitis, cholecystitis, and obstructive jaundice, leading to presumptive diagnosis of cholangiocarcinoma. However, the final diagnosis was made using endoscopic retrograde cholangiopancreatography following inspection of flat, leaf-shaped, motile flukes extracted from the bile duct. In one patient with ascariasis, a longitudinal tubular structure was identified in the bile duct; emergency surgery was required. Conclusion: The diagnosis of parasitic diseases is clinically challenging, and definitive diagnosis requires endoscopic retrograde cholangiopancreatography in some cases. Moreover, endoscopic retrograde cholangiopancreatography provides a therapeutic option for ascariasis, fascioliasis, and some forms of hydatidosis. Accordingly, the use of endoscopic retrograde cholangiopancreatography may change preoperative management and treatment strategies for biliary system parasite infections.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endoscopic retrograde cholangiopancreatography for biliary system parasites

et al. 2018

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“…In Korea, cattle were heavily infected with Fasciola species before 2000 with a prevalence of up to 38.2% [ 7 , 8 , 9 ]. Additionally, there were several cases of human infections with F. hepatica [ 10 , 11 ]. However, recent studies on trace animals and the prevalence of fascioliasis are lacking.…”

Section: Introductionmentioning

confidence: 99%

Fasciola hepatica in Snails Collected from Water-Dropwort Fields using PCR

et al. 2014

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Fasciola hepatica is a trematode that causes zoonosis mainly in cattle and sheep and occasionally in humans. Fascioliasis has been reported in Korea; however, determining F. hepatica infection in snails has not been done recently. Thus, using PCR, we evaluated the prevalence of F. hepatica infection in snails at 4 large water-dropwort fields. Among 349 examined snails, F. hepatica-specific internal transcribed space 1 (ITS-1) and/or ITS-2 markers were detected in 12 snails and confirmed using sequence analysis. Morphologically, 213 of 349 collected snails were dextral shelled, which is the same aperture as the lymnaeid snail, the vectorial host for F. hepatica. Among the 12 F. hepatica-infected snails, 6 were known first intermediate hosts in Korea (Lymnaea viridis and L. ollula) and the remaining 6 (Lymnaea sp.) were potentially a new first intermediate host in Korea. It has been shown that the overall prevalence of the snails contaminated with F. hepatica in water-dropwort fields was 3.4%; however, the prevalence varied among the fields. This is the first study to estimate the prevalence of F. hepatica infection using the vectorial capacity of the snails in Korea.

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“…Mammalian hosts acquire F. hepatica infection through ingestion of contaminated vegetation or water containing viable metacercariae of F. hepatica throughout their lifetimes [25,26], so older hosts have more opportunities to ingest encysted dormant larvae. In the present study, age was considered as a risk factor associated with F. hepatica infection in yaks.…”

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confidence: 99%

Seroprevalence and Risk Factors of Fascioliasis in Yaks, Bos grunniens, from Three Counties of Gansu Province, China

Zhang

Feng

et al. 2017

Korean J Parasitol

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The aim of this study was to determine the seroprevalence and risk factors of fascioliasis in yaks, Bos grunniens, from 3 counties of Gansu Province in China. A total of 1,584 serum samples, including 974 samples from white yaks from Tianzhu, 464 from black yaks from Maqu, and 146 from black yaks from Luqu County, were collected and analyzed using ELISA to detect IgG antibodies against Fasciola hepatica. The overall F. hepatica seroprevalence was 28.7% (454/1,584), with 29.2% in white yaks (284/974) and 27.9% in black yaks (170/610). The seroprevalence of F. hepatica in yaks from Tianzhu, Luqu, and Maqu was 29.2%, 22.6%, and 29.5%, respectively. Female yaks (30.9%) had higher F. hepatica seroprevalence than male yaks (23.4%). Also, F. hepatica seroprevalence varied by different age group from 24.1% to 33.8%. Further, the seroprevalence ranged from 21.8% to 39.1% over different seasons. Interestingly, the season and age of yaks were associated with F. hepatica infection in yaks in the investigated areas. These findings provided a basis for further studies on this disease in yaks from 3 counties of Gansu Province in northwestern China, which may ultimately support the development of effective control strategies of fascioliasis in these areas.

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A Case of Fasciola hepatica Infection Mimicking Cholangiocarcinoma and ITS-1 Sequencing of the Worm

Cited by 25 publications

References 8 publications

Endoscopic retrograde cholangiopancreatography for biliary system parasites

Endoscopic retrograde cholangiopancreatography for biliary system parasites

Fasciola hepatica in Snails Collected from Water-Dropwort Fields using PCR

Seroprevalence and Risk Factors of Fascioliasis in Yaks, Bos grunniens, from Three Counties of Gansu Province, China

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