A Case of Fixed Drug Eruption Aggravated by Redosage.

Kuribayashi, Michiyo; Nagayama, Hirotoshi; Endo, Hisayoshi; Shinkai, Hiroshi

doi:10.2336/nishinihonhifu.62.642

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2003

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“…It has been reported that systemic exposure to the drug can cause more extensive lesions after repeated occurrences of FDE (6, 7). There was even a case of multiple FDE in which the provocation test unfortunately resulted in the development of Stevens–Johnson syndrome (8). In Japan, there were 2 reported cases of a mucocutaneous‐ocular syndrome‐type of drug eruption due to allylisopropylacetylurea.…”

Section: Discussionmentioning

confidence: 99%

Non‐pigmenting fixed drug eruption caused by allylisopropylacetylurea

et al. 2003

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An unusual case of a non-pigmenting fixed drug eruption caused by allylisopropylacetylurea is reported. Several hours after taking an analgesic (New Kaiteki A), a 30-year-old Japanese woman, who had experienced similar eruptions several times after taking other analgesics, developed numerous variously sized, itchy, round-to-oval erythematous eruptions on the trunk and extremities. After she discontinued taking this drug, all such eruptions resolved within 2 weeks, without leaving postinflammatory pigmentation. Patch testing with New Kaiteki A itself and one of its active ingredients, allylisopropylacetylurea, on lesional skin, but not on uninvolved skin, showed positive erythematous reactions after 2 days.

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Section: Discussionmentioning

confidence: 99%