Non‐pigmenting fixed drug eruption caused by allylisopropylacetylurea

Numata, Yukikazu; Terada, Tadashi; Sasai, Shu; Sugawara, Masayuki; Kikuchi, Katsuko; Tagami, Hachiro; Aiba, Setsuya

doi:10.1111/j.0105-1873.2003.0212.x

Cited by 4 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Allylisopropylacetylurea is often reported as a cause of FDE in Japan. [1][2][3][4] In our case, the clinical features, which mimicked contact dermatitis of the face, were quite different from those of typical FDE.…”

Section: Discussioncontrasting

confidence: 56%

Fixed drug eruption caused by allylisopropylacetylurea mimicking contact dermatitis of the face

et al. 2019

View full text Add to dashboard Cite

Allylisopropylacetylurea, which has a hypnotic and sedative effect, is contained in several over-the-counter analgesics in Japan. We report an unusual case of fixed drug eruption (FDE) caused by allylisopropylacetylurea, clinically mimicking contact dermatitis of the face. CASE REPORTA 52-year-old Japanese woman presented with diffuse itchy erythema with small vesicles and crusts on her face ( Figure 1A). There were no other skin lesions except for one small round erythema on her left forearm ( Figure 1B), and her lips and oral mucosa were not involved.She reported that itchy erythema developed on her face and forearm a few hours after taking one tablet of EveA, an over-the-counter analgesic. She had sometimes taken different types of analgesics for the treatment of headache but had only experienced itchy erythema on the face once previously, which had been relieved by intravenous steroid treatment. She had no medical history or medication regimen.

show abstract

Section: Discussioncontrasting

confidence: 56%

Fixed drug eruption caused by allylisopropylacetylurea mimicking contact dermatitis of the face

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In our patient, 3 different nonprescription NSAIDs were suspected of being the causative drugs. In Japan, >140 general medicines, including these nonprescription NSAIDs, include allylisopropylacetylurea, an ingredient that causes hypnotic and analgesic effects [6][7][8]. Allylisopropylacetylurea is the ingredient most reported as a cause of FDE in Japan.…”

Section: Discussionmentioning

confidence: 99%

Fixed Drug Eruption Associated with Nonsteroidal Anti-Inflammatory Drugs for Menstrual Pain: A Case Report

Shimizu¹,

Tsushima²,

Komiya³

et al. 2022

Case Rep Dermatol

View full text Add to dashboard Cite

Fixed drug eruption (FDE) is a type of drug reaction in which cutaneous or mucocutaneous lesions recur at the same site due to repeated administration of the causative drug. The most reported FDE-inducing drugs are nonsteroidal anti-inflammatory drugs (NSAIDs). We report a case of FDE associated with the use of NSAIDs for menstrual pain. A 33-year-old woman was referred to our department with blisters and soreness on her lips, tongue, and labial mucosa. The results of blood examination helped rule out herpes simplex virus infection, pemphigus, and pemphigoid. An FDE was suspected because these symptoms coincided with the use of NSAIDs for menstrual pain. Thus, the patient was advised not to use these NSAIDs but to use acetaminophen instead. No recurrence has been observed since the patient began avoiding these NSAIDs.

show abstract