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Allylisopropylacetylurea, which has a hypnotic and sedative effect, is contained in several over-the-counter analgesics in Japan. We report an unusual case of fixed drug eruption (FDE) caused by allylisopropylacetylurea, clinically mimicking contact dermatitis of the face. CASE REPORTA 52-year-old Japanese woman presented with diffuse itchy erythema with small vesicles and crusts on her face ( Figure 1A). There were no other skin lesions except for one small round erythema on her left forearm ( Figure 1B), and her lips and oral mucosa were not involved.She reported that itchy erythema developed on her face and forearm a few hours after taking one tablet of EveA, an over-the-counter analgesic. She had sometimes taken different types of analgesics for the treatment of headache but had only experienced itchy erythema on the face once previously, which had been relieved by intravenous steroid treatment. She had no medical history or medication regimen.