Fixed drug eruption caused by allylisopropylacetylurea mimicking contact dermatitis of the face

Abstract

Allylisopropylacetylurea, which has a hypnotic and sedative effect, is contained in several over-the-counter analgesics in Japan. We report an unusual case of fixed drug eruption (FDE) caused by allylisopropylacetylurea, clinically mimicking contact dermatitis of the face. CASE REPORTA 52-year-old Japanese woman presented with diffuse itchy erythema with small vesicles and crusts on her face ( Figure 1A). There were no other skin lesions except for one small round erythema on her left forearm ( Figure 1B), and her lips and oral mucosa were not involved.She reported that itchy erythema developed on her face and forearm a few hours after taking one tablet of EveA, an over-the-counter analgesic. She had sometimes taken different types of analgesics for the treatment of headache but had only experienced itchy erythema on the face once previously, which had been relieved by intravenous steroid treatment. She had no medical history or medication regimen.

Fixed Drug Eruption Associated with Nonsteroidal Anti-Inflammatory Drugs for Menstrual Pain: A Case Report

“…In our patient, 3 different nonprescription NSAIDs were suspected of being the causative drugs. In Japan, >140 general medicines, including these nonprescription NSAIDs, include allylisopropylacetylurea, an ingredient that causes hypnotic and analgesic effects [6][7][8]. Allylisopropylacetylurea is the ingredient most reported as a cause of FDE in Japan.…”