A Case of Gastrointestinal Bleeding due to Duodenal Metastasis from a Testicular Choriocarcinoma

Vardaros, Magdalene; Subhani, Miral; Rizvon, Kaleem; Gotlieb, Vladimir; Mustacchia, Paul; Freedman, Lester; Garg, Vikas; Singh, Jaspreet; Siddiqui, Ghulam

doi:10.1007/s12029-012-9433-y

Cited by 10 publications

(9 citation statements)

References 14 publications

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“…It should be noted that about 5% of these patients may present with a metastatic localisation on the digestive tract[ 2 ]. The most frequent origin for embryonal carcinoma is testicular (33% of cases), as confirmed by the literature[ 1 ]. The pineal gland, the mediastinal region, the digestive tract, the lungs and the retroperitoneum could well be the primitive origin of an embryonal carcinoma[ 3 ].…”

Section: Introductionmentioning

confidence: 76%

“…Melanoma, renal, mammary, bronchopulmonary, gastric or testicular neoplasia[ 4 ] represent the most frequent metastatic tumours at the level of the small bowel, and particularly at the level of the duodenum. However, in young men, a testicular origin is to be favoured due to the preferential epidemiology of these cancers in this population group[ 1 ]. It should be noted that tumours with testicular germ cells are dichotomized between seminomas and non-seminomatous germ cell tumours, such as embryonary carcinomas and teratomas[ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…The sites of dissemination of testicular embryonary carcinomas which are most frequently mentioned are the lungs, the liver and the retroperitoneal space. The digestive tract provides a rare but known dissemination area (5%)[ 1 ]. Fu et al[ 6 ] reported the case of a young patient with a symptomatic duodenal metastasis which induced low digestive bleeding.…”

Section: Discussionmentioning

confidence: 99%

“…The hypothesis of a retro-differentiation of adenocarcinoma cells at the level of embryonal ectodermal cells of a metaplasia or differentiation in trophoblastic precursor seems to explain the histology of this primitive embryonal duodenal tumour[ 9 ]. As well as metastasis with choriocarcinoma of testicular origin, the tumoural cellular profile is not homogeneous[ 1 ]. This accounts for the biopsy initial result matching with a limited sample of the tumoural lesion.…”

Section: Discussionmentioning

confidence: 99%

“…In young men, aged between 15 and 35, testicular cancer is the leading cause of neoplasia, with an incidence rate of 2.1 for 100000[ 1 ]. It should be noted that about 5% of these patients may present with a metastatic localisation on the digestive tract[ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Real case of primitive embryonal duodenal carcinoma in a young man

Barbieux¹,

Méméo²,

Blasi³

et al. 2017

WJG

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We report here the case of a young man suffering from a rare germ cell tumour. The patient was a 25-year-old man who was referred to our centre for asthenia, stinging epigastric pain, and an iron deficiency anaemia. Gastroscopy revealed a circumferential vegetating lesion on the second portion of the duodenum. The lesion was indurated at the third portion of the duodenum, responsible for a tight stenosis. A computerized tomography-scan of the chest, abdomen and pelvis, and a pancreatic MRI showed a circumferential lesion with a bi-ductal dilatation (i.e., of the common bile duct and Wirsung’s duct) without metastatic localisation. The patient underwent a pancreaticoduodenectomy with lymph node dissection including all cellular adipose tissues of the hepatic pedicle from the hepatic common artery and of the retroportal lamina. Histological findings were suggestive of a duodenal embryonal carcinoma with pancreatic infiltration. This is the second published case highlighting the duodenal primitive localisation of an embryonal carcinoma with pancreatic infiltration.

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Section: Introductionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Real case of primitive embryonal duodenal carcinoma in a young man

Barbieux¹,

Méméo²,

Blasi³

et al. 2017

WJG

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Peri‐treatment adverse events of primary mediastinal non‐seminomatous germ cell tumors

Chen

Liu

et al. 2022

Pediatric Blood & Cancer

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Primary mediastinal non-seminomatous germ cell tumors (PMNSGCT) are rare but life-threatening thoracic cancers. We report our experience from eight patients with peri-treatment adverse events. By analyzing changes in tumor extent, serum tumor markers, and pathologies between diagnosis and transfer, those events could be attributed to postbiopsy respiratory insufficiency, growing teratoma syndrome, secondary histiocytic malignancy, and PMNSGCT progression. Subjecting patients to respiratory therapy, conventional or high-dose chemotherapy, and surgery controlled the disease, with five of the eight patients surviving disease free. These outcomes indicate that integrated appropriate and timely approaches are important in tackling peritreatment adverse events. K E Y W O R D Sgrowing teratoma syndrome, multimodal intervention, peri-treatment adverse events, primary mediastinal non-seminomatous germ cell tumors, tandem high-dose therapy 1 RESULTSBetween 2013 and 2020, eight male non-Klinefelter syndrome patients with PMNSGCT were transferred to our institute (Koo Foundation Sun Yat-Sen Cancer Center), who presented with diverse peri-treatment adverse events that had arisen at various timeframes following their primary cancer treatments. The clinicopathologic

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Testicular Choriocarcinoma: a Rare Variant that Requires a Unique Treatment Approach

Reilley

Pagliaro

2015

Curr Oncol Rep

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Testicular germ cell tumors represent the most common malignancy among young men. While 5-year overall survival and cure for this population is greater than 95%, choriocarcinoma is an aggressive subtype of this disease with far worse prognosis--5-year survival for choriocarcinoma is less than 80%. In order to be able to treat these patients appropriately, a provider must recognize characteristic features of choriocarcinoma including elevated human chorionic gonadotropin in a young man with testicular mass; the astute clinician should also know the signs and symptoms of choriocarcinoma syndrome, characterized by bleeding from metastatic sites, which represents a medical emergency and is associated with high morbidity and mortality. Treatment should be directed towards a goal of tumor marker normalization, and patients with refractory disease should be considered for advanced therapies and clinical trials. Choriocarcinoma is a unique and aggressive germ cell malignancy, and these patients require early aggressive treatment to improve their chance of survival.

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A Case of Gastrointestinal Bleeding due to Duodenal Metastasis from a Testicular Choriocarcinoma

Cited by 10 publications

References 14 publications

Real case of primitive embryonal duodenal carcinoma in a young man

Real case of primitive embryonal duodenal carcinoma in a young man

Peri‐treatment adverse events of primary mediastinal non‐seminomatous germ cell tumors

Testicular Choriocarcinoma: a Rare Variant that Requires a Unique Treatment Approach

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