A Case of Glottic Amyloidosis Presenting as Leukoplakia

Abstract

Amyloidosis is defined as a deposit of amyloid substance. While it rarely occurs in the head and neck region, it is most commonly found in the larynx. Laryngeal amyloidosis can occur in the false vocal cord, ventricle, and glottis etc. The typical feature of laryngeal amyloidosis is a round yellowish submucosal mass. A 72-year-old male presented with voice change that began a couple of years ago. The rigid laryngoscopy showed a whitish patch in the medial and superior surfaces of the left true vocal fold. He was pathologically diagnosed with amyloidosis by laryngeal microsurgery. With a relevant review of literature, we report this case as it demonstrates rare, atypical features of laryngeal amyloidosis.