A Case of Henoch-Schönlein Purpura Nephritis in Pulmonary Tuberculosis

Kitamura, Hideya; Shimizu, Kenichiro; Takeda, Hiroshi; Tai, Hisakazu; Ito, Yoriko; Fukunaga, Masao

doi:10.1097/00000441-200702000-00010

Cited by 16 publications

(7 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study concluded that the antigen/antibody ratio within the lesions might be crucial in modulating the balance between tissue destruction and healing (27). Another study of humans showed that the occurrence of Henoch-Schönlein purpura nephritis in patients with pulmonary tuberculosis was associated with the deposition of circulating immune complexes (18). While the presence of ICs is established in both circulation and in tissues in many inflammatory responses, including TB, the triggers and mediators downstream of the IC have been less well studied.…”

mentioning

confidence: 99%

Immune Complexes Isolated from Patients with Pulmonary Tuberculosis Modulate the Activation and Function of Normal Granulocytes

Senbagavalli

Hilda

Ramanathan

et al. 2012

Clin Vaccine Immunol

View full text Add to dashboard Cite

cCirculating immune complexes (ICs) are associated with the pathogenesis of several diseases. Very little is known about the effect of ICs on the host immune response in patients with tuberculosis (TB). The effects of ICs isolated from patients with TB in modulating the release of calcium, cytokines, and granular proteins were studied in normal granulocytes, as were their chemotactic, phagocytic, and oxidative burst processes. ICs from TB patients induced decreased production of cytokines and plateletactivating factor (PAF) from normal granulocytes. ICs from TB patients also induced enhanced chemotaxis and phagocytosis but caused diminished oxidative burst. This was accompanied by an increased release in intracellular calcium. On the other hand, ICs from TB patients induced increased release of the granular proteins human neutrophil peptides 1 to 3 (HNP1-3). Thus, ICs from patients with TB exhibit a profound effect on granulocyte function with activation of certain effector mechanisms and dampening of others.

show abstract

mentioning

confidence: 99%

Immune Complexes Isolated from Patients with Pulmonary Tuberculosis Modulate the Activation and Function of Normal Granulocytes

Senbagavalli

Hilda

Ramanathan

et al. 2012

Clin Vaccine Immunol

View full text Add to dashboard Cite

show abstract

“…In some patients, HSP presents with the classical symptoms of tuberculosis. [10] In other patients, the occurrence of HSP might be induced by factors other than tuberculosis, for example, the anti-tuberculosis agents. [11] We reviewed many studies published in the past 30 years, and 8 adult tuberculosis cases showed HSP as a manifestation.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary tuberculosis presenting as henoch–schönlein purpura

Wang

et al. 2020

Medicine

View full text Add to dashboard Cite

Introduction: Henoch–Schönlein purpura (HSP) is an extremely rare condition in patients with pulmonary tuberculosis, with only a few reported cases. Compared to patients with typical clinical symptoms, it is difficult to make a definitive diagnosis when HSP presents as an initial manifestation in pulmonary tuberculosis patients. Herein, a case of pulmonary tuberculosis that showed HSP at first was reported, and the related literatures were reviewed. Patient Concerns: A 24-year-old man presented with palpable purpura on the extremities, accompanied by abdominal pain, bloody stools, and knee pain. Diagnoses: The patient was diagnosed with pulmonary tuberculosis based on the results of interferon gamma release assays, purified protein derivative test, and computed tomography. Interventions: The patient was treated with vitamin C and chlorpheniramine for 2 weeks, and the above-mentioned symptoms were relieved. However, 3 weeks later, the purpura recurred with high-grade fever and chest pain during the inspiratory phase. The patient was then treated with anti-tuberculosis drugs, and the purpura as well as the high fever disappeared. Outcomes: The patient recovered well and remained free of symptoms during the follow-up examination. Conclusion: Pulmonary tuberculosis presenting with HSP as an initial manifestation is not common. Therefore, it is difficult to clinically diagnose and treat this disease. When an adult patient shows HSP, it is important to consider the possibility of tuberculosis to avoid misdiagnosis and delayed treatment.

show abstract

“…We searched for relevant English and Japanese articles in PubMed using the following keywords: IgA vasculitis, Henoch‐Schönlein purpura or leukocytoclastic vasculitis, and tuberculosis. Twenty‐six cases considered as IgAV met the classification criteria set by the ACR or the EULAR/PRINT/PRES 9‐29 ; these consisted of 14 cases before the treatment of tuberculosis (pretreatment group) and 12 cases after the treatment of tuberculosis (post‐treatment group) (Tables 1 and 2). The overall median age of patients was 37 years, and 19 (73.1%) of them were male.…”

Section: Discussionmentioning

confidence: 99%