A Case of Hepatic Carcinosarcoma with Bile Duct Tumor Thrombi

Endo, Kazuhira; Terajima, Hiroaki; Imai, Yukihiro; Ito, Kyo; Ogura, Yasuhiro; Wada, Michihiko; Hosotani, Ryo

doi:10.5833/jjgs.41.99

Cited by 7 publications

(1 citation statement)

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“…In many cases, the sarcomatous component of hepatic carcinosarcoma comprises osteosarcomatous or chondrosarcomatous elements. 4 The carcinomatous component can be hepatocellular carcinoma, cholangiocellular carcinoma, or a combination of both. The present case showed both an osteosarcoma component and hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

MR Imaging of Carcinosarcoma of the Liver using Gd-EOB-DTPA

et al. 2014

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We present a case of a 69-year-old man with primary hepatic carcinosarcoma who underwent computed tomography that revealed a hypervascular hepatic tumor with local dense calcification. Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging revealed hyperintense lesions in the hepatobiliary phase that indicated hepatocellular carcinoma with bile production. The patient underwent right lobectomy, and the presence of a sarcoma component within the tumor on histopathology confirmed liver carcinosarcoma that included hepatocellular carcinoma. In cases with atypical images that resemble this case, the hyperintensity of a lesion in the hepatobiliary phase aids differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

MR Imaging of Carcinosarcoma of the Liver using Gd-EOB-DTPA

et al. 2014

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Surgical outcomes for 131 cases of carcinosarcoma of the hepatobiliary tract

Okabayashi¹,

Shima²,

Iwata³

et al. 2013

J Gastroenterol

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Carcinosarcoma of the hepatobiliary tract is highly aggressive and has a poor prognosis even after curative resection. The purpose of this study was to collate and analyze published data to clarify the surgical outcome of carcinosarcoma of the hepatobiliary tract and the relationships between potential prognostic factors and survival after surgery. We surveyed worldwide literature from 1970 to 2012 and obtained clinicopathological data for 131 patients who had undergone surgical resection for carcinosarcoma of the hepatobiliary tract, including one patient from our clinic. The relationships between potential prognostic factors and survival rates were examined using the Kaplan-Meier method and the log-rank test. The overall 1-, 3-, and 5-year survival rates for patients with carcinosarcoma of the hepatobiliary tract after surgery were 44.0, 29.3, and 27.0 %, respectively. In univariate analyses, age and gender were not significant prognostic factors; however, advanced stage according to the classification of the Union for International Cancer Control in resected specimens was significantly associated with a shorter survival time after surgery. Although carcinosarcoma of the hepatobiliary tract remains a rare disease worldwide, its poor prognosis, even after curative resection, demands further epidemiological and pathological study that could lead to the development of new management strategies.

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Carcinosarcoma of the liver: report of a case

et al. 2013

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A 64-year-old Japanese woman without a history of viral hepatitis was admitted for investigation of a huge liver mass. The tumor, measuring 14 × 12 × 22 cm, had invaded the diaphragm, right lung, and inferior vena cava. Serum examinations demonstrated high levels of carbohydrate antigen 19-9 (CA19-9), and the Child-Pugh score was A. She underwent right lobectomy of the liver and partial resection of the right diaphragm, right lung, and inferior vena cava. Radio- and chemotherapy were also given, but she died of recurrence 3 months after surgery. Microscopically, the tumor exhibited intermingled adenocarcinomatous and atypical mesenchymal components. The carcinomatous component was positive for cytokeratins 7, 19, and 20, chromogranin A, epithelial membrane antigen, c-KIT, and vimentin. The sarcomatous component was positive for vimentin and c-KIT. A review of 36 cases of hepatic carcinosarcoma revealed the following: chronic hepatitis or cirrhosis in 57 % of the patients; increased serum CA19-9 levels in 30 %; a mean tumor diameter of 10 cm; invasion of the adjacent organs or metastasis to distant organs in 47 %; wide intrahepatic infiltration in 44 %; and 50 % survival of only 5 months. Significant differences were seen according to tumor diameter (diameter >5 cm; p < 0.05), wide intrahepatic infiltration (p < 0.05), and extrahepatic invasion/metastasis (p < 0.01). Neither chemotherapy nor radiotherapy contributed to prognosis, but surgical resection resulted in some improvement (p < 0.05).

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A Case of Hepatic Carcinosarcoma with Bile Duct Tumor Thrombi

Cited by 7 publications

References 0 publications

MR Imaging of Carcinosarcoma of the Liver using Gd-EOB-DTPA

MR Imaging of Carcinosarcoma of the Liver using Gd-EOB-DTPA

Surgical outcomes for 131 cases of carcinosarcoma of the hepatobiliary tract

Carcinosarcoma of the liver: report of a case

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