A Case of Hepatoma Associated with Vibrio vulnfcus Bacteremia and its Bacteriological findings

Maeda, Yasuhiro; Fukuda, Koji; Irimajiri, Kiyohiro; Horiuchi, Atsushi; Takenaka, Seigo; Furuta, Itaru; Ohba, Yasuhiro; Azuma, I; Harada, Kazuhiro; Kitaura, Toshiyuki

doi:10.11150/kansenshogakuzasshi1970.56.335

kansenshogakuzasshi

1982

DOI: 10.11150/kansenshogakuzasshi1970.56.335

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A Case of Hepatoma Associated with Vibrio vulnfcus Bacteremia and its Bacteriological findings

Yasuhiro Maeda¹,

Koji Fukuda²,

Kiyohiro Irimajiri³

et al.

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Cited by 5 publications

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“…V. vulnificus is part of the normal bacterial flora of estu-arine waters and occurs in high numbers in molluscan shellfish around the world (25, 26). It has been isolated from coastal waters (35) and fish (29) of Japan, and clinical cases are also common in that country (18,28). Fujisawa et al (10) determined that 29% of the necrotizing fasciitis cases diagnosed at one hospital were due to this pathogen.…”

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confidence: 99%

A Rapid and Simple PCR Analysis Indicates There Are Two Subgroups of Vibrio vulnificus Which Correlate with Clinical or Environmental Isolation

Rosche

Yano

Oliver

2005

Microbiology and Immunology

195

238

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Of all concerns which face the shellfish industry, none are currently as critical as the presence of V. vulnificus in oysters. In fact, 95% of all deaths resulting from seafood consumption in the United States are caused by this bacterium (25). Fatality rates of over 50%, with median incubation times to onset of symptoms ranging from as little as 7 hr to several days, have been reported (24). In Japan, a recent study reported a fatality rate of over 68% (15). Between 1989 and 2000, 274 cases involving oyster ingestion occurred in the United States, of which 142 (52%) were fatal. Most (ϳ95%) cases occur in males, since females are protected from the V. vulnificus endotoxin by estrogen (19). V. vulnificus is part of the normal bacterial flora of estuarine waters and occurs in high numbers in molluscan shellfish around the world (25,26). It has been isolated from coastal waters (35) and fish (29) of Japan, and clinical cases are also common in that country (18,28). Fujisawa et al. (10) determined that 29% of the necrotizing fasciitis cases diagnosed at one hospital were due to this pathogen. V. vulnificus infections and its isolation from waters and seafood are also common in Korea (6,30,36), China (3,7,38), Hong Kong (1, 5), and Taiwan (13). Despite this, a recent study by Osaka et al. (28) revealed that of 235 emergency room physicians in Japan, less than 16% had a basic knowledge of V. vulnificus infection.Most ( Abstract: Vibrio vulnificus is an estuarine bacterium which is the causative agent of both food-borne disease and wound infection. Although V. vulnificus is commonly found in molluscan shellfish at high numbers, the incidence of disease is relatively low, leading to the hypothesis that not all strains of V. vulnificus are equally virulent. Unfortunately, there is currently no easy test to identify virulent strains of this species. We have previously identified a 200 bp randomly amplified polymorphic DNA (RAPD) PCR amplicon associated with clinical isolates. DNA sequence data from this locus in six clinical and four environmental isolates showed that the strains could be divided into two groups, which we termed C-type (correlates with clinical origin) and E-type (correlates with environmental origin). We designed PCR primers that could distinguish between the two groups, and typed 55 randomly selected strains. We found that 90% of the C-type strains were clinical isolates, while 93% of environmental isolates were classified as E-type. The region directly downstream of this locus contained a heptanucleotide sequence repeated various times depending on the strain. Using a PCR-based assay to detect the repeat number present in a given strain, we found a statistically significant correlation with the C/E type classification and the number of repeats. The data reported here are consistent with the existence of two genotypes of V. vulnificus, with the C-type being a strong indicator of potential virulence.

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mentioning

confidence: 99%

A Rapid and Simple PCR Analysis Indicates There Are Two Subgroups of Vibrio vulnificus Which Correlate with Clinical or Environmental Isolation

Rosche

Yano

Oliver

2005

Microbiology and Immunology

195

238

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“…." Based on the results of these and other studies noting differences in such traits as flagellation (13), serology (17), lactose fermentation (1), outer membrane protein pattern (23), siderophore production (18,23), and enzyme production (15), we decided to investigate the nature and significance of the isogenic variants and to determine whether they are common to all strains of V. vulnificus.…”

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confidence: 99%

Correlation between virulence and colony morphology in Vibrio vulnificus

Simpson¹,

White²,

Zane³

et al. 1987

Infect Immun

191

106

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Of 38 isolates of Vibrio vulnificus examined, all avirulent strains produced only translucent colonies. All virulent strains, with the exception of biogroup 2 (eel pathogens), exhibited both opaque and translucent colonies. Isogenic morphotypes were examined for a variety of phenotypic and virulence traits. Only the ability to utilize transferrin-bound iron and the presence of a surface polysaccharide were found to correlate with colony opacity and virulence.

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A case ofVibrio vulnificus infection

Ohta

Kato

Boku

et al. 1988

The Japanese Journal of Surgery

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Vibrio vulnificus, a recently described strain of the halophilic Vibrio species, was isolated from the blood of a 73-year-old man, who developed rapidly progressive wound infection and fatal septicemia. Twenty-one patients with Vibrio vulnificus infection have been reported in the Japanese literature. Vibrio vulnificus most frequently causes primary septicemia and necrotising cellulitis after the eating of raw fish or shellfish or after exposure to seawater. The infection is characterized by its occurring during the warm months of the year, in patients with underlying diseases, especially liver diseases, and the mortality rate is surprisingly high. Clinicians should therefore consider the possibility of Vibrio vulnificus infection in the differential diagnosis of severe wound infections. Early surgical intervention and intensive antibiotic therapy are recommended for preventing the progress of the septicemia.

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A Case of Hepatoma Associated with Vibrio vulnfcus Bacteremia and its Bacteriological findings

Cited by 5 publications

References 0 publications

A Rapid and Simple PCR Analysis Indicates There Are Two Subgroups of Vibrio vulnificus Which Correlate with Clinical or Environmental Isolation

A Rapid and Simple PCR Analysis Indicates There Are Two Subgroups of Vibrio vulnificus Which Correlate with Clinical or Environmental Isolation

Correlation between virulence and colony morphology in Vibrio vulnificus

A case ofVibrio vulnificus infection

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