A Case of Hyperostosis Frontalis Interna with Frontal Lobe Dysfunction

Hyperostosis frontalis interna in a patient with Alzheimer's disease

“…HFI accounts for neuropsychiatric symptoms, including cognitive impairment, hypochondria, executive dysfunction, epilepsy, and headache. [3][4][5] Here, we present a case of Alzheimer's disease with HFI.…”

“…Thus, the high prevalence of HFI may be related to oestrogen levels. 1 Previous Japanese reports of HFI [3][4][5] showed cognitive impairment; however, in almost all cases, a differential diagnosis was not considered for dementia. HFI does not cause significant clinical disease and is rarely encountered in Japan.…”