A case of inv dup(8p) with early onset breast cancer

The structural rearrangement in the short arm of a chromosome 8 in a clinically affected patient has been reinvestigated by FISH using whole chromosome painting and region specific YAC probes. An inverted duplication of the segment p22→p11.2 and a deletion of the subtelomeric region were demonstrated. By this approach, a more detailed resolution of the duplication/deletion 8p was possible. With the application of molecular cytogenetic methods the existence of different duplication segments within the clinical entity of duplication/deficiency 8p can be shown.

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A case of inv dup(8p) with early onset breast cancer

Cited by 4 publications

References 9 publications

Duplication 8 〚inv dup(8)(p12p23)〛 with macrocephaly

Duplication 8 〚inv dup(8)(p12p23)〛 with macrocephaly

Chromosomal comparative genomic hybridization abnormalities in early- and late-onset human breast cancers: correlation with disease progression and TP53 mutations

The application of region-specific probes for the resolution of duplication 8p: a case report and a review of the literature

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