A case of left foot drop as initial symptom of granulomatosis with polyangiitis: Triggered by COVID‐19 disease?

Weynand, Marjolaine; Raftakis, Ioannis; Chérif, Yassine Mohammad; Lecomte, Sophie; Badot, Valérie

doi:10.1002/ccr3.6418

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…By June 2023 (searching PubMed,CNKI and Wanfang Data ), a total of 9 English cases of GPA following COVID-19 infection involvement and no Chinese case were found by searching literature [4][5][6][7][8][9][10][11][12]. Combined with our case,there were 10 cases of GPA following COVID-19 infection.…”

Section: Results From the Literature Reviewmentioning

confidence: 53%

COVID-19- induced Granulomatosis with Polyangiitis：a Case Report and Literature Review

Jiang,

Zhou,

Wen

et al. 2024

Preprint

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Objective To report a case of Granulomatosis with Polyangiitis (GPA)with Diffuse alveolar hemorrhage(DAH)that developed following Coronavirus disease 2019 (COVID-19) in an adolescent boy, and perform a literature review to better understand this disorder.Methods Retrospectively analyze the data of a case of GPA following COVID-19 infection, to summarize the clinical characteristics of GPA following COVID-19 infection by searching the database (PubMed,Wanfang Data,CNKI) and comprehensively analyze the literature results. Results 9 cases were reported，combined with our case，there were 10 cases of GPA following COVID-19 infection,including 4 males and 6 females,with an average age of(40.6±18.6)years,and the time interval between COVID-19 and diagnosis of GPA ranged from 1 day to 3 months for all 10 cases. The rate of mortality was 10.0%(1/10).Commonly seen clinical manifestations were cough(70.0%),dyspnea(50.0%),and Arthralgia/Myalgia(40.0%). CT scans showed ground-glass opacities，multifocal pulmonary nodules.Of all these patients, c-ANCA and PR3-antibody positivity were found .Conclusion COVID-19 pneumonia and COVID-19- induced new-onset GPA share many clinical and radiological features, making it challenging for clinicians to distinguish between the two. Our study also provided some clues about the diagnostic challenge of GPA induced by COVID-19.

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Section: Results From the Literature Reviewmentioning

confidence: 53%

COVID-19- induced Granulomatosis with Polyangiitis：a Case Report and Literature Review

Jiang,

Zhou,

Wen

et al. 2024

Preprint

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A case of left foot drop as initial symptom of granulomatosis with polyangiitis: Triggered by COVID‐19 disease?

Weynand

Raftakis

Chérif

et al. 2022

Clinical Case Reports

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COVID‐19‐induced granulomatosis with polyangiitis: A case report of a 16‐year‐old East Asian and literature review

Jiang,

Zhou,

Wen

et al. 2024

Immunity Inflam & Disease

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ObjectiveAntineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV) is divided into granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and eosinophilic GPA. It is one of the most severe and potentially fatal autoimmune inflammatory conditions. The etiology and pathology of AAV are complex and poorly understood. Since the onset of the Coronavirus Disease 2019 (COVID‐19) pandemic, numerous reports have documented GPA cases following COVID‐19, suggesting a potential link between COVID‐19 and the development of GPA. This case report discusses a 16‐year‐old East Asian boy who developed GPA with diffuse alveolar hemorrhage after contracting COVID‐19. Additionally, a literature review was conducted to gain a deeper understanding of this disorder.MethodsThe study involved a retrospective analysis of the data of a case of GPA post‐COVID‐19 infection, aiming to summarize the clinical characteristics of GPA post‐COVID‐19 infection through a search of databases (PubMed, Wanfang Data, and CNKI), supplemented by standard searches in Google Scholar, Cochrane, Scopus, and LitCovid, and to conduct a comprehensive analysis of the literature.ResultsA total of 12 cases were identified and, when combined with the present case, yielded 13 cases of GPA post‐COVID‐19 infection, comprising 5 males and 8 females with an average age of (40.6 ± 19.5) years. The interval between COVID‐19 infection and the diagnosis of GPA varied from 1 day to 3 months across all cases. Mortality was reported at 7.7% (1/13). The most common clinical manifestations included cough (69.2%) and dyspnea (46.1%). Computed tomography scans revealed ground‐glass opacities and multifocal pulmonary nodules. In all cases, positive findings for c‐ANCA and protease 3‐antibody were observed. Renal involvement was observed in more than half of the patients.

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A case of left foot drop as initial symptom of granulomatosis with polyangiitis: Triggered by COVID‐19 disease?

Cited by 4 publications

References 30 publications

COVID-19- induced Granulomatosis with Polyangiitis：a Case Report and Literature Review

COVID-19- induced Granulomatosis with Polyangiitis：a Case Report and Literature Review

A case of left foot drop as initial symptom of granulomatosis with polyangiitis: Triggered by COVID‐19 disease?

COVID‐19‐induced granulomatosis with polyangiitis: A case report of a 16‐year‐old East Asian and literature review

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