A case of Lhermitte-Duclos disease presenting high FDG uptake on FDG-PET/CT

Nakagawa, Toshio; Maeda, Masayuki; Kato, Mikiyoshi; Terada, Naohiro; Shimizu, Shigetoshi; Morooka, Yoshito; Nakano, Hiroshi; Takeda, Kan

doi:10.1007/s11060-007-9355-x

Cited by 13 publications

(15 citation statements)

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“…Magnetic resonance imaging (MRI) is considered to be the best modality imaging option for characterization of LDD by some authors [1,3,5] but the impact of functional imaging provided by nuclear medicine is recommended in other studies [2,5,6]. Various authors have described the potential role of molecular imaging provided by positron emission tomography (PET) and single-photon emission computed tomography in the metabolic evaluation of LDD, by using radiotracers such as fluorine-18-fluorodeoxyglucose (F18-FDG) [2,5,6], thallium-201 [5] and C11-methionine [7].…”

Section: Introductionmentioning

confidence: 99%

Lhermitte-Duclos disease presenting with positron emission tomography-magnetic resonance fusion imaging: a case report

et al. 2012

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IntroductionLhermitte-Duclos disease or dysplastic gangliocytoma of the cerebellum is an extremely rare tumor. It is a slowly enlarging mass within the cerebellar cortex. The majority of cases are diagnosed in the third or fourth decade of life.Case presentationWe report the case of a 37-year-old Caucasian woman who underwent positron emission tomography-computed tomography with fluorine-18-fluorodeoxyglucose for evaluation of a solitary lung node. No pathological uptake was detected in the solitary lung node but the positron emission tomography-computed tomography of her brain showed intense tracer uptake, suggestive of a malignant neoplasm, in a mass in her left cerebellar lobe. Our patient had experienced two years of occipital headache and movement disorder. Subsequently, magnetic resonance imaging was performed with contrast agent administration, showing a large subtentorial mass in her left cerebellar hemisphere, with compression and dislocation of the fourth ventricle. Metabolic data provided by positron emission tomography and morphological magnetic resonance imaging views were fused in post-processing, allowing a diagnosis of dysplastic gangliocytoma with increased glucose metabolism. Total resection of the tumor was performed and histological examination confirmed the diagnosis of Lhermitte-Duclos disease.ConclusionsOur case indicates that increased uptake of fluorine-18-fluorodeoxyglucose may be misinterpreted as a neoplastic process in the evaluation of patients with Lhermitte-Duclos disease, but supports the usefulness of integrated positron emission tomography-magnetic resonance imaging in the exact pathophysiologic explanation of this disease and in making the correct diagnosis. However, an accurate physical examination and exact knowledge of clinical data is of the utmost importance.

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Section: Introductionmentioning

confidence: 99%

Lhermitte-Duclos disease presenting with positron emission tomography-magnetic resonance fusion imaging: a case report

et al. 2012

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“…Approximately half of LDD cases are associated with CD (7). Careful systemic investigation for CD should thereby be performed in LDD patients (7). In the present case, genetic testing for CD yielded negative results and sporadic isolated LDD was diagnosed.…”

Section: Discussionmentioning

confidence: 67%

“…Most cases documented have occurred in adults in the third and fourth decades of life, with no sex predilection (2,8). LDD in the elderly is quite rare, with only 5 other cases reported in patients over 60 years old (2,(5)(6)(7)10). Table I summarizes the clinical features of LDD in the elderly, including the present case.…”

Section: Discussionmentioning

confidence: 79%

“…Angiography shows LDD as an avascular mass (5). On FDG-PET, LDD displays high uptake of FDG, similar to malignant tumors (2,3,7). The reason for this high uptake of FDG remains unclear, and may simply reflect focally increased cell density and/or changes in the metabolism of dysplastic ganglion cells (3).…”

Section: Resultsmentioning

confidence: 99%

“…CT usually reveals a low-density mass in the lesion and calcification is sometimes present (2,6,8). MRI shows the lesion better than CT, with a characteristic striated (2,5,7,10). In addition, extensive resection risks include neurological deficits such as cerebellar mutism (1).…”

Section: Discussionmentioning

confidence: 99%

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Lhermitte-duclos disease treated surgically in an elderly patient: case report and literature review

Matsumoto¹,

Minami²,

Yoshida³

2014

Turkish Neurosurgery

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A 75-year-old man with Lhermitte-Duclos Disease (LDD) manifesting as progressive headache is presented. Magnetic resonance imaging demonstrated a right cerebellar mass lesion with the characteristic "tiger-striped appearance". A mild mass effect was evident at the medulla oblongata, accompanied by inferior displacement of the right cerebellar tonsil. Thus, tonsillar herniation was considered the cause of his headache and he underwent partial resection of the tumor to solve tonsillar herniation. His headache gradually improved. LDD in the elderly is quite rare. Several differences in the nature of the lesion are seen in the elderly, with tendencies toward a male predominance, hypervascularity, and low rates of association with Cowden disease. Moreover, partial resection to reduce mass effect can improve clinical symptoms without recurrence. In symptomatic LDD in the elderly, to avoid surgical complication, we recommend partial resection to reduce mass effect. KeywOrds: Dysplastic gangliocytoma, Elderly patient, Headache, Lhermitte-Duclos Disease ÖZYetmiş beş yaşında bir erkek hastada progresif baş ağrısı ile ortaya çıkan Lhermitte-Duclos Hastalığı (LDH) sunulmaktadır. Manyetik rezonans görüntüleme "Kaplan çizgileri" görünümü olan bir sağ serebellar kitle lezyonunu gösterdi. Medulla oblongata'da hafif bir kitle etkisi vardı ve sağ serebellar tonsil inferiora doğru yer değiştirmişti. Bundan dolayı tonsiller heniasyonun baş ağrısına neden olduğu düşünüldü ve hastaya tonsiller herniasyonun tedavisi için tümörün parsiyel rezeksiyonu uygulandı. Hastanın baş ağrısı tedrici olarak düzeldi. LDH yaşlılarda oldukça nadirdir. Bu hastalığın yaşlılarda görülen formunda tümörün natüründe bazı farklılıklar vardır. Bunlar, erkek predominansı, hipervaskülarite ve Cowden hastalığı ile daha düşük oranda birlikteliktir. Ayrıca parsiyel rezeksiyon kitle etkisini azaltarak nüks olmadan klinik semptomların iyileşmesini sağlamıştır. Semptomatik LDH olan yaşlı hastalarda cerrahi komplikasyondan kaçınmak için kitle etkisini azaltmak amacıyla parsiyel rezeksiyon yapılmasını öneriyoruz.

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Thyroid disease associated with cowden syndrome: A meta‐analysis

2012

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BackgroundWe investigated the pathology and surgical management of thyroid disease in patients with Cowden syndrome (CS).MethodsA query of the PubMed database between 2001 and January 2010 was performed using the terms “cowden syndrome OR cowden's syndrome OR cowden disease OR cowden's disease.” Original articles, reviews, case reports, and case series were included. Articles were excluded if they were not written in English, did not present case/cases of CS, or did not include patient information to qualify for a diagnosis of CS. Ninety‐five articles met the inclusion and exclusion criteria. A total of 181 cases were analyzed.ResultsOf the 181 patients, 99 female (54.7%) and 77 male patients (42.5%) had sex reported. The age at presentation ranged from 3 days to 78 years. Ninety‐six patients (96/181, 53.0%) were reported to have thyroid disease. Surgical management of thyroid disease was performed in 80.2% (77/96) of patients with thyroid disease, with total thyroidectomy being the most common operation reported (23/77, 29.9%). Thyroid pathology reported with CS patients included goiter (39/96, 40.6%), adenoma (24/96, 25%), unknown/unspecified pathology (8/96, 8.3%), follicular carcinoma (7/96, 7.3%), thyroiditis (7/96, 7.3%), papillary carcinoma (6/96, 6.3%), cancer (unknown type) (3/96, 3.1%), medullary carcinoma (1/96, 1%), and hyperthyroidism (1/96, 1%).ConclusionCareful monitoring of thyroid disease in CS patients is imperative. © 2012 Wiley Periodicals, Inc. Head Neck, 2013

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A case of Lhermitte-Duclos disease presenting high FDG uptake on FDG-PET/CT

Cited by 13 publications

References 9 publications

Lhermitte-Duclos disease presenting with positron emission tomography-magnetic resonance fusion imaging: a case report

Lhermitte-Duclos disease presenting with positron emission tomography-magnetic resonance fusion imaging: a case report

Lhermitte-duclos disease treated surgically in an elderly patient: case report and literature review

Thyroid disease associated with cowden syndrome: A meta‐analysis

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