A Case of Lymphomatoid Papulosis with Extensive Limb Disease Followed by Extracutaneous Involvement and Acquired Ichthyosis

Type D Lymphomatoid Papulosis: An uncommon Variant. A case report and review of the literature

“…Spontaneous regression of LyP is seen almost universally and recurrence in crops establish a chronicity that generally last for years, even though most of patients with LyP remain in good health. No clinical or pathological features can predict increased risk for developing malignancy and although it is not an aggressive malignant process, patients with LyP have an increased risk for developing a nonlymphoid tumour or more commonly a lymphoma (10-20%) including mycosis fungoides, Hodgkin's disease, and cutaneous and systemic CD30+ large-cell lymphoma and 10% of these are associated with extracutaneous involvement [3,9,21,22,[27][28][29][30]. The prognosis of LyP is characterized by disease-specific 5-year survival rates around 100%.…”

Acquired ichthyosis, asteatotic dermatitis or xerosis? An update on pathoetiology and drug‐induced associations

“…Concomitant use of topical emollients, keratolytics, and topical or oral retinoids, along with ponatinib dose reduction in one case, showed variable efficacy in reducing scaling while allowing for continuation of potentially life‐saving TKI therapy 77,100,101 . Topical corticosteroids, despite having no direct role in treating hyperkeratosis in the congenital ichthyoses, have been efficacious in select cases of AI, suggesting a possible atopic component 41,74–77,102 …”

“…[34][35][36][37][38][39][40] Lymphomatoid papulosis, considered to be on the benign end of the spectrum of primary cutaneous CD30 + T-cell lymphoproliferative disorders, has also been reported with AI. 36,41,42 Morizane et al 38 followed a cohort of 106 patients with malignant lymphomas and found ichthyosiform eruption in nine patients-three with ALK-negative ALCL and six with MF. Histopathology of ichthyotic lesions from ALCL patients was consistent with AI, while those of MF patients were diagnosed as AI, IMF, or containing features of both diseases.…”

Acquired ichthyosis associated with primary cutaneous CD30+ lymphoproliferative disorders

“…There are only a few reported cases in the literature of AI associated with primary cutaneous CD30 + LPDs [2][3][4]. Some authors hypothesized that LyP or C-ALCL patients with AI have a poorer prognosis than those without ichthyosis, suggesting that a more careful follow-up may be required [4]. In the reported cases, we highlight in the first patient a progressive worsening of the ichthyosiform eruption along the course of the LyP, however, this phenomenon was not related to a more aggressive clinical course.…”

“…A year and a half after diagnosis the patient remains free of disease and without ichthyosiform eruption. There are only a few reported cases in the literature of AI associated with primary cutaneous CD30 + LPDs [2][3][4]. Some authors hypothesized that LyP or C-ALCL patients with AI have a poorer prognosis than those without ichthyosis, suggesting that a more careful follow-up may be required [4].…”