A case of malignant fibrous histiocytoma of the liver.

Nakajima, Nobuhisa; Une, Yoshie; Satoh, Yuuji; Satoh, Naoki; Nakajima, Yasuaki; Uchino, J; Houkin, Syuichi; Nojima, Takayuki

doi:10.2957/kanzo.31.337

Cited by 5 publications

(3 citation statements)

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“…The absence of distinct characteristic features makes a preoperative diagnosis of hepatic MFH extremely difficult [1]. A differential diagnosis should include cystadenoma, cystadenocaricinoma, hepatocellular carcinoma, and a variety of poorly differentiated sarcomas, such as angiosarcoma or liposarcoma [6].…”

Section: Discussionmentioning

confidence: 99%

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Four-year survival of a patient with malignant fibrous histiocytoma of the liver treated with surgery and chemotherapy

Shioya

Yuzuriha

Maejima

et al. 2008

Clin J Gastroenterol

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Malignant fibrous histiocytoma of the liver is an extremely rare tumor. A 43-year-old woman was admitted with an enlargement of the abdomen and a feeling of general fatigue. A clinical examination revealed a right liver giant cystic tumor (18.5 × 22 cm). The cystic tumor, which contained a solid component, occupied almost the entire right lobe of the liver, and a solid S4 tumor was also observed. A blood examination revealed severe anemia and mild liver dysfunction. During hospitalization intratumor bleeding occurred. A right lobectomy of the liver and lymph node dissection was performed after transcatheter arterial embolization. Histopathologically, the tumor was diagnosed as a primary storiform-pleomorphic-type malignant fibrous histiocytoma of the liver. One year after the radical operation, the patient developed recurrences in other organs. She received 17 cycles of chemotherapy with etoposide, ifosfamide, and cisplatin. The recurrent tumors decreased in size, but new recurrences in other organs occurred. The patient died of respiratory failure 4 years and 2 months after the initial operation.

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Section: Discussionmentioning

confidence: 99%

“…It occurs in the fifth and sixth decades of human life with no predilection for either sex. MFH is thought to be a type of undifferentiated mesenchymal polymorphic cell sarcoma that is capable of differentiating into histiocytic cells or fibroblastic cells [1].…”

Section: Discussionmentioning

confidence: 99%

Four-year survival of a patient with malignant fibrous histiocytoma of the liver treated with surgery and chemotherapy

Shioya

Yuzuriha

Maejima

et al. 2008

Clin J Gastroenterol

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“…Das MFH der Leber stellt eine Rarität dar. In der Literatur wurden bislang lediglich 19 Fälle mit einem primären MFH der Leber dokumentiert (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Wir berichten hier -unseres Erachtens zum ersten Es wird über ein pri m ä res Sarkom der Leber bei einem 43jähri gen Pa t i e n ten beri ch tet, der we gen Dyspnoe, Oberbauch s ch m e rzen, Durch fall und Fieber in das Un i ve rs i tä t s k l i n kum Göt t i n gen aufge n o m m e n w u rde.…”

Section: Kasuistik Einleitungunclassified

Malignes fibröses Histiozytom der Leber

Schweyer

Meyer-Venter²,

Lorf³

et al. 2000

Z Gastroenterol

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We report on a 43-year-old man with a primary sarcoma of the liver. The patient was admitted to the hospital for evaluation of dyspnea, abdominal pain in the right upper quadrant, diarrhea, and fever. Physical examination revealed hepatomegaly. Increased laboratory values were found for gamma-GT, LDH, CA 125, and NSE, but not for aspartate and alanine aminotransferase. Computed tomography presented a tumor in the right lobe of the liver. Venous cavography revealed a caval tumor thrombus reaching up to the right atrium. Major liver resection combined with replacement of the vena cava inferior was proposed, but before operation the patient complained about shortness of breath. Spontaneous fragmentation of the tumor thrombus with consecutive embolization of the lungs was suspected. Despite lysis therapy the patient died because of right ventricular failure. Autopsy revealed a tumor measuring 8 cm in diameter, which was located in the right lobe of the liver and invaded the inferior vena cava. Because of multiple tumor aggregates seen in the left and right main pulmonary arteries acute tumor embolization of the lungs was regarded as cause of death. Histologically the tumor was composed of bizarre giant cells surrounded by irregular spindle cells. The positive immunoreactivity pattern of the tumor cells for vimentin, lysozym, and CD68 justified the diagnosis of a malignant fibrous histocytoma (MFH) of the liver.

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Primary hepatic malignant fibrous histiocytoma: Report of a case and review of the literature

Fujita

Lauwers

1998

Pathology International

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Malignant fibrous histiocytoma (MFH) is a common sarcoma of adulthood, frequently arising in the extremities, but also in the abdomen and the retroperitoneum. Primary MFH of the liver, however, remains extremely rare and is one of the least diagnosed primary hepatic sarcoma. Another case of primary MFH of the liver is reported. The patient presented with a 12 cm mass involving the right and left lobes of the liver. The histopathologic examination revealed a typical MFH swirling (storiform) pattern composed of atypical spindle and giant cells. The radiologic, histologic, and clinical behavior of this rare neoplasm are reviewed.

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A case of malignant fibrous histiocytoma of the liver.

Cited by 5 publications

References 0 publications

Four-year survival of a patient with malignant fibrous histiocytoma of the liver treated with surgery and chemotherapy

Four-year survival of a patient with malignant fibrous histiocytoma of the liver treated with surgery and chemotherapy

Malignes fibröses Histiozytom der Leber

Primary hepatic malignant fibrous histiocytoma: Report of a case and review of the literature

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