Primary hepatic malignant fibrous histiocytoma: Report of a case and review of the literature

Fujita, Shiro; Lauwers, Gregory Y.

doi:10.1111/j.1440-1827.1998.tb03897.x

Cited by 22 publications

(4 citation statements)

References 12 publications

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“…Ossification and dystrophic calcification are often present in cases of musculoskeletal and retroperitoneal MFH. However, these findings are never seen in hepatic MFH (25)(26)(27). Furthermore, of 16 cases with pancreatic MFH, only 1 case showed evidence of calcification (8).…”

Section: Discussionmentioning

confidence: 75%

Primary Malignant Fibrous Histiocytoma of the Pancreas: A Case with K-rasMutation and a Review of the Literature

Akatsu

Tsugita

et al. 2005

Dig Dis Sci

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Section: Discussionmentioning

confidence: 75%

Primary Malignant Fibrous Histiocytoma of the Pancreas: A Case with K-rasMutation and a Review of the Literature

Akatsu

Tsugita

et al. 2005

Dig Dis Sci

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“…Primary sarcomas of the liver are extremely rare tumors and represent approximately 0.2% of all primary liver tumors 1. They include a heterogeneous group of histologic types, such as angiosarcoma, leiomyosarcoma, epitheloid hemangioendothelioma, fibrosarcoma, malignant fibrous histiocytoma, and undifferentiated embryonal sarcoma of the liver (UESL) 2–5. UESL normally occurs in the pediatric age group, particularly between ages 6 years and 10 years.…”

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confidence: 99%

Undifferentiated embryonal sarcoma of the liver in adults

Lenze

Birkfellner

Lenz

et al. 2008

Cancer

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BACKGROUND Undifferentiated embryonal sarcoma of the liver (UESL), a rare tumor that predominantly affects children, generally has been considered an aggressive neoplasm with an unfavorable prognosis. More recent reports have indicated that modern multimodal treatment and supportive care improve the survival of children with UESL. Data regarding the treatment and survival of adults have not been reviewed comprehensively, and only a few adult patients with UESL have been reported in the literature. METHODS The authors analyzed demographics, treatment, and actuarial survival of all reported cases of UESL in patients aged ≥15 years (n = 67 patients). In addition, 1 case is presented of a patient with UESL who was treated successfully at the authors' institution. RESULTS The median survival of all patients with UESL who were analyzed was 29 months. Patients who underwent complete tumor resection followed by adjuvant chemotherapy survived over a median follow‐up of 28.5 months and had significantly better survival compared with patients who underwent surgical treatment alone. Patients who underwent an incomplete tumor resection had a tendency toward poorer outcomes. CONCLUSIONS To the authors' knowledge, this is the first report to demonstrate a significant effect on survival for adjuvant chemotherapy after complete surgical resection of UESL in adults. The role of neoadjuvant chemotherapy was not evaluated in this study. In the case study presented herein, combined therapy with surgery and chemotherapy led to a complete, sustained remission that has lasted for >6 years to date. Cancer 2008. © 2008 American Cancer Society.

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“…Das MFH der Leber stellt eine Rarität dar. In der Literatur wurden bislang lediglich 19 Fälle mit einem primären MFH der Leber dokumentiert (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Wir berichten hier -unseres Erachtens zum ersten Es wird über ein pri m ä res Sarkom der Leber bei einem 43jähri gen Pa t i e n ten beri ch tet, der we gen Dyspnoe, Oberbauch s ch m e rzen, Durch fall und Fieber in das Un i ve rs i tä t s k l i n kum Göt t i n gen aufge n o m m e n w u rde.…”

Section: Kasuistik Einleitungunclassified

Malignes fibröses Histiozytom der Leber

Schweyer

Meyer-Venter²,

Lorf³

et al. 2000

Z Gastroenterol

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We report on a 43-year-old man with a primary sarcoma of the liver. The patient was admitted to the hospital for evaluation of dyspnea, abdominal pain in the right upper quadrant, diarrhea, and fever. Physical examination revealed hepatomegaly. Increased laboratory values were found for gamma-GT, LDH, CA 125, and NSE, but not for aspartate and alanine aminotransferase. Computed tomography presented a tumor in the right lobe of the liver. Venous cavography revealed a caval tumor thrombus reaching up to the right atrium. Major liver resection combined with replacement of the vena cava inferior was proposed, but before operation the patient complained about shortness of breath. Spontaneous fragmentation of the tumor thrombus with consecutive embolization of the lungs was suspected. Despite lysis therapy the patient died because of right ventricular failure. Autopsy revealed a tumor measuring 8 cm in diameter, which was located in the right lobe of the liver and invaded the inferior vena cava. Because of multiple tumor aggregates seen in the left and right main pulmonary arteries acute tumor embolization of the lungs was regarded as cause of death. Histologically the tumor was composed of bizarre giant cells surrounded by irregular spindle cells. The positive immunoreactivity pattern of the tumor cells for vimentin, lysozym, and CD68 justified the diagnosis of a malignant fibrous histocytoma (MFH) of the liver.

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Primary hepatic malignant fibrous histiocytoma: Report of a case and review of the literature

Cited by 22 publications

References 12 publications

Primary Malignant Fibrous Histiocytoma of the Pancreas: A Case with K-rasMutation and a Review of the Literature

Primary Malignant Fibrous Histiocytoma of the Pancreas: A Case with K-rasMutation and a Review of the Literature

Undifferentiated embryonal sarcoma of the liver in adults

Malignes fibröses Histiozytom der Leber

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