Primary Malignant Fibrous Histiocytoma of the Pancreas: A Case with K-rasMutation and a Review of the Literature

Akatsu, Tomotaka; Tsugita, Masashi; Ro, Seiichi; Kameyama, Kaori; Kitajima, Masaki

doi:10.1007/s10620-005-3037-3

Cited by 15 publications

(15 citation statements)

References 22 publications

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“…28e30 Point mutation of the K-ras oncogene is a frequent event in many gastrointestinal carcinomas. 31,32 However, little is known about the occurrence of this mutation in primary hepatic MFH.…”

Section: Introductionmentioning

confidence: 99%

Primary Hepatic Malignant Fibrous Histiocytoma Mimicking Hepatocellular Carcinoma: Report of Two Cases with Immunohistochemical Detection of Ezrin, and Ultrastructural and K-ras Mutation Analysis

Liew

Huang

Lin

et al. 2012

Journal of Experimental & Clinical Medicine

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Section: Introductionmentioning

confidence: 99%

Primary Hepatic Malignant Fibrous Histiocytoma Mimicking Hepatocellular Carcinoma: Report of Two Cases with Immunohistochemical Detection of Ezrin, and Ultrastructural and K-ras Mutation Analysis

Liew

Huang

Lin

et al. 2012

Journal of Experimental & Clinical Medicine

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“…The absence of characteristic epithelial markers such as desmin, keratin, S-100P, alpha-fetoprotein, and CEA can exclude the epithelial origin. In addition, UPS exhibits characteristic that have strong reactions to vimentin, alpha 1-antichymotrypsin, CD68, and lysozyme as this case did [15, 16]. Most UPS diagnosed tumors may be rather a poorly differentiated sarcoma, specially dedifferentiated liposarcomas.…”

Section: Discussionmentioning

confidence: 57%

Undifferentiated Pleomorphic Sarcoma of Pancreas: A Case Report and Review of the Literature for the Last Updates

Sanei

Kefayat

Samadi

et al. 2018

Case Reports in Medicine

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The most prevalent type of soft tissue sarcoma is undifferentiated pleomorphic sarcoma (UPS) or previously known as malignant fibrous histiocytoma. It accounts over 20% of all soft tissue sarcomas and occurs most frequently in the extremities, trunk, and retroperitoneum. However, it has been rarely observed in the digestive system. Pancreas sarcoma represents less than 1% of all pancreatic tumors, and primary UPS of the pancreas is even rarer. It exhibits high recurrence and poor prognosis. In this case, a 72-year-old woman with a UPS tumor which was located in the pancreas head and neck without adhesion to the retroperitoneum will be discussed.

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“…MFH is a common type of soft-tissue sarcoma, and the leg is the most common site of this disease. In contrast, the incidence of primary MFH of the pancreas is exceedingly low, with only 16 documented cases [17][18][19].…”

Section: Discussionmentioning

confidence: 95%

Pancreatic Metastasis From Musculoskeletal Sarcoma: A Case Report With Malignant Fibrous Histiocytoma and Review of the Literature

et al. 2007

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Estimates of the frequency of pancreatic metastases vary widely. At autopsy, the pancreas has been found to be a site of metastasis in 3-12% of patients with malignant tumors [1][2][3]. However, the occurrence of resectable metastasis to the pancreas is less frequent because many patients already have widespread disease at the time of diagnosis of pancreatic metastasis. Only 0.5-3.0% of patients who have undergone pancreatic resection demonstrated metastatic disease [4][5][6]. Surgical management of pancreatic metastasis is poorly defined because in the past the operative risks of pancreatic surgery were too high to justify [7]. Recent improvements in morbidity and mortality after pancreatic resection allow for radical surgery with curative intent [4][5][6]. Primary tumors that give rise most frequently to metastases to the pancreas include renal cell carcinoma, colorectal, breast, and lung cancers; pancreatic metastasis from sarcomas is extremely rare. Herein we report a case of very rare synchronous solitary metastasis to the pancreas from malignant fibrous histiocytoma (MFH, a most common type of soft-tissue sarcoma) [8,9]. Moreover, we review the literature to discuss the appropriate management of pancreatic metastasis from musculoskeletal sarcomas [10-16].A 62-year-old woman was referred to our hospital for evaluation of jaundice. Her medical history was unremarkable. The patient did not consume any medications. She denied smoking and alcohol intake. There was no family history of pancreatic disease or cancer. On admission, the patient was afebrile with stable vital signs. The abdomen was soft and slightly distended, with mild tenderness in the upper abdomen. The patient noticed a soft, nontender, palpable mass in the left lower leg. Magnetic resonance imaging (MRI) showed a 5-cm, irregularly enhanced mass in the center of the gastrocnemius muscle of the left lower leg (Fig. 1). The tumor did not involve neurovascular structures, bones, or joints. Biopsy demonstrated a polygonal or spindle cell sarcoma with prominent atypical nuclei.Laboratory test results included a white blood cell count of 7,600/mm 3 , a hemoglobin level of 10.2 g/dL, and platelets of 193,000/mm 3 . Biochemical tests demonstrated the presence of aspartate aminotransferase at

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Primary Malignant Fibrous Histiocytoma of the Pancreas: A Case with K-rasMutation and a Review of the Literature

Cited by 15 publications

References 22 publications

Primary Hepatic Malignant Fibrous Histiocytoma Mimicking Hepatocellular Carcinoma: Report of Two Cases with Immunohistochemical Detection of Ezrin, and Ultrastructural and K-ras Mutation Analysis

Primary Hepatic Malignant Fibrous Histiocytoma Mimicking Hepatocellular Carcinoma: Report of Two Cases with Immunohistochemical Detection of Ezrin, and Ultrastructural and K-ras Mutation Analysis

Undifferentiated Pleomorphic Sarcoma of Pancreas: A Case Report and Review of the Literature for the Last Updates

Pancreatic Metastasis From Musculoskeletal Sarcoma: A Case Report With Malignant Fibrous Histiocytoma and Review of the Literature

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