A case of metaplastic breast cancer in a man

Barr, James; Clayton, Elizabeth; Sotheran, Wendy

doi:10.1093/jscr/rjs047

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…1 In addition, the lung is the most common organ of metastasis during the progression of MSCCB. [14][15][16] Recently, some studies showed that a patient with a history of breast cancer has a higher risk of developing other primary non-mammary cancer types, particularly in the lung. [17][18][19] When a lung nodule is found in a patient with a history of MSCCB, it can be difficult to diagnose definitively whether it is metastatic MSCCB or primary lung squamous cell carcinoma (LUSC).…”

Section: Introductionmentioning

confidence: 99%

<p>SOX10 – A Novel Marker for the Differential Diagnosis of Breast Metaplastic Squamous Cell Carcinoma</p>

Qi¹,

Hu²,

Xiao³

et al. 2020

CMAR

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Introduction: Differential diagnosis of metaplastic squamous cell carcinoma of breast (MSCCB) is difficult. In particular, in terms of metastatic MSCCB, because of the low speciality of traditional markers such as mammaglobin, gross cystic disease fluid protein-15 (GCDFP-15) and GATA binding protein 3 (GATA3), the most common problem is differentiating the spread of MSCCB to the lung from a primary lung squamous cell carcinoma. It is urgently required to explore a novel marker to aid in differential diagnosis. Aim: The aim of this study is to explore a novel marker to aid in the differential diagnosis of MSCCB from other squamous cell carcinomas (SCC) in other organs. Methods: We tested the expression of SOX10 in 375 human SCC specimens with immunohistochemistry (IHC). Results: In a series of 20 MSCCB, 9 (45%) were positive for SOX10. All of them were triple-negative MSCCB. Conversely, SOX10 was totally negative in another 205 SCC originating from lung, skin, cervix, oral mucosa, and esophagus. In a series of 150 triplenegative breast cancer and their metastatic foci, SOX10 labeling in the primary tumor and metastasis was 78% and 79.3%, respectively, and the agreement rate was 97.3% (P>0.05). Conclusion: Our findings demonstrate that SOX10 was recommended for differentiating MSCCB from non-mammary metastasis to the breast, as well as for distinguishing primary SCC from metastatic MSCCB, and SOX10 may be valuable in the pathological diagnosis of breast-derived metaplastic squamous cell carcinoma.

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Section: Introductionmentioning

confidence: 99%

<p>SOX10 – A Novel Marker for the Differential Diagnosis of Breast Metaplastic Squamous Cell Carcinoma</p>

Qi¹,

Hu²,

Xiao³

et al. 2020

CMAR

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“…MBC accounts for less than 1% of breast cancer diagnoses and is extremely rare in males. We found only 5 cases of male MBC reported in the literature[ 1 - 5 ].…”

Section: Discussionmentioning

confidence: 99%

Male metaplastic breast cancer with poor prognosis: A case report

Kim¹,

Lee²,

Kim³

et al. 2022

WJCC

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BACKGROUND Metaplastic breast cancer (MBC) is a rare subtype of breast cancer. They constitute less than 1% of breast cancer cases and are much rarer in males. There are few reports of MBC because of its rarity. MBC, an aggressive type of cancer, is refractory to common treatment modalities of breast cancer and has a poor prognosis. CASE SUMMARY We report a case of MBC in a 78-year-old man. He visited our clinic with a palpable mass on the left breast with no masses in the axillary areas. He had previously undergone robot-assisted laparoscopic radical prostatectomy for prostate cancer, but there was no family history of malignancy. The breast mass was visible on ultrasonography, mammography, and magnetic resonance imaging, and chest computed tomography revealed a lung mass in the posterior basal segment of the right lower lobe. The patient was diagnosed with metaplastic carcinoma on core needle biopsy with lung metastasis. Total mastectomy with sentinel lymph node biopsy and video-assisted segmentectomy of the right lung was performed. However, multiple metastases appeared 3 mo after surgery in the brain, chest, and abdomen, and the patient died 5 mo after the initial diagnosis. CONCLUSION MBC is an aggressive and extremely rare breast cancer type. Further case reports are needed to determine the optimal treatment.

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“…It constitutes approximately 5% of all breast cancers in men, compared with 1%-2% in women with breast carcinomas (24). Non-Hodgkin lymphoma, malignant melanoma, oncocytic carcinoma, secretory carcinoma, mucinous carcinoma, and metaplastic carcinoma have been rarely reported (1,18,20,(24)(25)(26)(27)(28). Metastatic involvement of male breasts with SCC and melanoma are also identified sporadically (26).…”

Section: Discussionmentioning

confidence: 99%