A case of occupational asthma and rhinitis caused by Sanyak and Korean ginseng dusts

Lee, J.-Y.; Lee, Y.-D.; Bahn, Joon-Woo; Park, Hae‐Sim

doi:10.1111/j.1398-9995.2006.01032.x

Cited by 24 publications

(20 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several red ginseng-containing TCMIs [9] or ginsenoside-containing TCMIs [10] have been shown to cause ARs that may be related to components in red ginseng. Moreover, several cases of ARs induced by oral administration of ginseng or inhalation of ginseng dust have also been recently reported [11, 12]. Therefore, the allergenicity and potential allergens in red ginseng (especially its bioactive components) must be clarified to improve preparation methods and quality as well as to ensure safety of use.…”

Section: Introductionmentioning

confidence: 99%

Allergens in red ginseng extract induce the release of mediators associated with anaphylactoid reactions

et al. 2017

View full text Add to dashboard Cite

BackgroundAnaphylactoid reactions induced by preparations containing red ginseng have been reported. The aim of this study is to evaluate the allergenicity and screen potential allergens in red ginseng extract thoroughly.MethodsRed ginseng extract (RGE) and different fractions of RGE were prepared and evaluated by measuring the degranulation and viability of rat basophilic leukemia 2H3 (RBL-2H3) cells. Potential allergens were screened by RBL-2H3 cell extraction and allergenicity verified in RBL-2H3 cells, mouse peritoneal mast cells, Laboratory of Allergic Disease 2 (LAD2) human mast cells and mice, respectively.Results80% ethanol extract of red ginseng extract induced mast cell degranulation with less cytotoxicity, but 40% ethanol extract could not. Ginsenoside Rd and 20(S)-Rg3 could induce a significant increase in β-hexosaminidase release, histamine release and translocation of phosphatidylserine in RBL-2H3 cells. Ginsenoside Rd and 20(S)-Rg3 also increased β-hexosaminidase release and the intracellular Ca2+ concentration in mouse peritoneal mast cells and LAD2 cells. In addition, histamine levels in serum of mice were elevated dose-dependently.ConclusionsGinsenoside Rd and 20(S)-Rg3 are potential allergens that induce the release of mediators associated with anaphylactoid reactions. Our study could guide optimization of methods associated with Rd/20(S)-Rg3-containing preparations and establishment of quality standards for safe application of Traditional Chinese Medicines.

show abstract

Section: Introductionmentioning

confidence: 99%

Allergens in red ginseng extract induce the release of mediators associated with anaphylactoid reactions

et al. 2017

View full text Add to dashboard Cite

show abstract

“…42,43) However, the results of this study strongly suggest that batatasin I showed antiinflammatory effects via the inhibition of both eicosanoid generation and degranulation reaction in activated mast cells. SCF has been shown to induce histamine release of mature connective tissue-type mast cells as well as to induce directly mast cell chemotaxis.…”

Section: Generation and Cox-2 Protein Expressionmentioning

confidence: 40%

Batatasin I, a Naturally Occurring Phenanthrene Derivative, Isolated from Tuberous Roots of <i>Dioscorea batatas</i> Suppresses Eicosanoids Generation and Degranulation in Bone Marrow Derived-Mast Cells

Jin

Park

et al. 2011

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

To find anti-inflammatory compounds from the tuberous roots of Dioscorea batatas, we isolated 6-hydroxy-2,4,7-trimethoxyphenanthrene (batatasin I) from the dichloromethane (CH 2 Cl 2 ) fraction of this plant. Batatasin I inhibited both the generation of prostaglandin D 2 (PGD 2 ), leukotriene C 4 (LTC 4 ) and degranulation reaction in mouse bone marrow-derived mast cells (BMMCs). This compound inhibited cyclooxygenase-2 (COX-2) dependent PGD 2 generation in a dose dependent manner, with IC 50 values of 1.78 m mM. Western blotting probed with specific anti-COX-2 antibodies showed that the decrease in the quantity of the PGD 2 generation was accompanied by a decrease in the COX-2 protein level. In addition, this compound also inhibited the production of 5-lipoxygenase (5-LOX) dependent LTC 4 in a dose dependent manner (IC 50 , 1.56 m mM). Batatasin I also inhibited the mast cell degranulation reaction (IC 50 , 6.7 m mM) in BMMCs. This result indicates that batatasin I could be developed as an anti-inflammatory agent through further investigation.

show abstract

“…When used as alternative medicine, patients can experience severe allergic reactions after ginseng treatment. There have been 2 case reports regarding ginseng-induced asthma and anaphylaxis; both patients were sensitized to the pollen of birch and alder trees 2627. Clinicians should consider ginseng as a possible culprit for OAS.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea

Park

Son

Lee

et al. 2016

Allergy Asthma Immunol Res

View full text Add to dashboard Cite

PurposeClinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic reaction in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. The purpose of this study was to discriminate true peanut food allergy from cross-reactive hypersensitivity in birch-sensitized peanut allergy.MethodsBirch-sensitized (n=81) and peanut anaphylaxis patients (n=12) were enrolled. Peanut-related allergic reactions and sensitization profiles were examined. Specific IgE to Fagales tree pollens (birch, oak), peanut, and their component allergens (Bet v 1, Bet v 2, Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Ara h 9) were evaluated. Based on these specific IgEs and clinical features, the patients were classified into 4 groups: group 1 (Fagales pollen allergy without OAS), group 2 (Fagales pollen allergy with OAS), group 3 (OAS with peanut anaphylaxis), and group 4 (peanut anaphylaxis).ResultsAfter peanut consumption, one-third of OAS patients experienced oral symptoms not associated with peanut sensitization. Ara h 1 or Ara h 2 was positive in peanut anaphylaxis patients, whereas Ara h 8 was positive in OAS patients. There were 4 patients with both peanut anaphylaxis and OAS (group 3). Both Ara h 2 and Ara h 8 were positive in these patients. Foods associated with OAS in Korea showed unique patterns compared to Westernized countries.ConclusionsAra h 2 and Ara h 8 may be important component allergens for discriminating peanut allergy.

show abstract

A case of occupational asthma and rhinitis caused by Sanyak and Korean ginseng dusts

Cited by 24 publications

References 6 publications

Allergens in red ginseng extract induce the release of mediators associated with anaphylactoid reactions

Allergens in red ginseng extract induce the release of mediators associated with anaphylactoid reactions

Batatasin I, a Naturally Occurring Phenanthrene Derivative, Isolated from Tuberous Roots of <i>Dioscorea batatas</i> Suppresses Eicosanoids Generation and Degranulation in Bone Marrow Derived-Mast Cells

Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea

Contact Info

Product

Resources

About