A case of optic perineuritis—A literature review of Japanese cases and clinical problems

Abstract

suppression images demonstrated abnormal enhancement, "tram track" sign on the axial view (arrows) and "doughnut" sign on the coronal view (broad arrow), of the right optic nerve sheath. The similar hyperintensity configurations (arrow heads) to both signs could be recognized on T 2 -weighted MR (C, D, F). These intensity changes were suggested to be due to tissue edema.A: axial T 1 weighted image (1.5 T, TR 654 ms, TE 10 ms), B; contrast enhanced axial T 1 weighted image with fat suppression (1.5 T, TR673 ms, TE 10 ms), C; contrast enhanced axial T 2 weighted image with fat suppression (1.5 T, TR 5,000 ms, TE 90 ms), D; contrast enhanced coronal T 2 weighted image with fat suppression (1.5 T, TR 5,000 ms, TE 90 ms), E; axial FLAIR image (1.5 T, TR 5,000 ms, TE 87 ms), F; axial T 2 weighted image with fat suppression (1.5 T, TR 4,930 ms, TE 88 ms), G; contrast enhanced axial T 1 weighted image with fat suppression (1.5 T, TR 778 ms, TE 13 ms), H; contrast enhanced coronal T 1 weighted image with fat suppression (1.5 T, TR 554 ms, TE 13 ms). 57：719Review of the literature for cases of idiopathic optic perineuritis in Japan.

Optic Perineuritis Associated with Nivolumab Treatment for Non-Small Cell Lung Cancer

“…The outcome of steroid treatment is dependent on the time between the appearance of symptoms and initiation of treatment [5,11]. The idiopathic group reportedly had a better convalescence than the second group [14]. In the present case, steroid administration had little effect on the patient's symptoms despite prompt treatment initiation.…”

Two patients of visual disturbance and optic perineuritis after placement of a flow diverter

“…The “doughnut sign” on the coronal images and the “tram-track sign” on the axial images in orbital MRI indicate optic perineuritis [ 6 , 7 ] or impaired perfusion of spinal fluid around the optic nerve due to compression. It causes symptoms such as ocular pain, visual disturbance, papilledema, eye movement disturbance, and eyelid drooping.…”

“…It causes symptoms such as ocular pain, visual disturbance, papilledema, eye movement disturbance, and eyelid drooping. Causes of optic perineuritis include antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, hypertrophic pachymeningitis, allergic granulomatous vasculitis (Churg-Strauss syndrome), granulomatosis with polyangiitis, and anti-GQ1b antibody syndrome, as well as systemic inflammatory diseases such as Bickerstaff's brainstem encephalitis, osteodysplastic syndrome, aseptic meningitis, and liver cancer [6] . Idiopathic and secondary recurrences are frequent; however, their response to steroids is good.…”

Optic Perineuritis: How Does it Differ from Optic Neuritis?

“…Clinical findings, VF test, OCT and MRI take an important role in differential diagnosis. 1,2 The diagnosis of OPN is based on clinical and radiological findings. Patients symptoms may consist of sudden or progressive visual loss in one eye accompanied or not by eye pain.…”

“…It has been reported that syphilis, tuberculosis, sarcoidosis, giant cell arteritis, Crohn disease, herpes zoster, Wegener granulomatosis are specific causes of OPN. 1,2,4 Familial Mediterranean fever (FMF) is an auto-inflammatory disease which starts during childhood or adolescence with recurrent poly- serositis attacks. Although it has been reported that uveitis, retinal ischemia, cataract, glaucoma and retinal detachment are related to FMF, optic nerve involvement has been rarely reported in the literature.…”