A Case of Orbital Xanthogranuloma Treated by Surgical Excision

Abstract

Orbital xanthogranuloma is an uncommon tumor. It is usually associated with a systemic or hematological disease. This report presents a rare case of orbital xanthogranuloma associated with heart disease and thrombocytopenia. A 52-year-old female presented with a bilateral periorbital subcutaneous tumor that had existed for 3 years. Although immunoglobulin levels were within the normal limits, thrombocytopenia, slight anemia and increased levels of C-reactive protein and alkaline phosphatase were observed. The mass was excised successfully. The malar flap elevation technique made it easy to approach the periorbital subcutaneous mass. A histopathological study led to a diagnosis of xanthogranuloma based on the presence of infiltration of histiocytes and Touton-type giant cells.

Adult-onset asthma with periocular xanthogranuloma (AAPOX), a variant of periorbital xanthogranulomatous disease: An uncommon entity

“…[ 10 ] Adult-onset orbital xanthogranuloma presents with isolated orbital involvement without accompanying immune dysfunction, asthma or paraproteinemia. [ 11 ] Patients with AAPOX lack the typical systemic associations of ECD, but have the onset of differing degrees of adult-onset asthma near the time that their periocular lesions appear.…”

Total Resection of Unilateral Adult-onset Xanthogranuloma of the Orbit via a Transcranial Orbital Approach

“…A literature review revealed 12 patients with AOX who had been treated surgically, including our case (Table 1). 1,5–8) Patient age ranged from 23 to 79 years, and sex distribution was equal. Four patients (33%) had bilateral involvement.…”

“…This report describes a patient with orbital xanthogranuloma that was completely resected via a transcranial orbital approach without requiring any systemic treatment. 2,5)…”

Surgical treatment of adult‐onset xanthogranuloma

“…A 39-year-old male patient admitted to our clinic with bilateral periorbital yellowish plaques and papulonodules that had been present for Many treatment modalities such as corticosteroids, chemotherapy, radiotherapy, or surgery have been used with varying success rates in AOXD, however, there is no consensus on the most effective treatment option yet. [4][5][6] AOX usually does not require aggressive treatment unlike the other subtypes of the disease. 7 For that reason, even in the recurrent In conclusion, disfiguring recurrent skin lesions can be treated with complete surgical resection.…”