A case of ovarian dysgerminoma with gonadal dysgenesis in 29-year-old woman with 46,XX karyotype

Abstract

Gonadal dysgenesis occurs in rare case of ovarian tumor. Most tumors associated with gonadal dysgenesis were gonadoblastomas and dysgerminomas. In addition, premature ovarian insufficiency associated with these ovarian tumors in normal chromosomal type had not reported in many cases. A 29-year-old nulligravida woman who was concurrented with ovarian dysgerminoma and fibroma is presented. Measurements were made on serum lactate dehydrogenase, CA-125, CA 19-9 and pelvis ultrasonography and computed tomography. The clinical stage was IA and right salpingo-oophorectomy and wedge resection of the left ovary were done. On laboratory finding after operation on her serum follicular stimulating hormone was increased and E 2 was decreased. The result of chromosomal analysis was 46,XX, normal. We represent here with brief review of literature one case of gonadal dysgenesis in nulligravida woman, associated with dysgerminoma, with normal karyotype.

Ovarian dysgerminoma: a case report

“…2 It arises by malignant transformation of the primodial germ cells and in some cases may occur on anomalies of genital tract such as gonadal dysplasia. 3 They usually arise in young women between 10 and 30 years of age. These tumors grow rapidly, and present as abdominal pain and large tumour mass in the abdomen.…”

Ovarian Dysgerminoma / Disgerminom Jajnika

“…It belongs to the group of germ tumours of the ovary and arises by the malignant alteration of the primordial germ cells. In some cases, the tumour may occur on the anomalies of the genital tract, such as gonad dysplasia or testicular feminization [1]. It usually occurs in patients aged 20 to 30 years.…”