A Case of Pigmented Bowen's Disease

Lee, Jung Woo; Hur, Jae Young; Yeo, Kwang Yeoll; Yu, Hee Joon; Kim, Joung Soo

doi:10.5021/ad.2009.21.2.197

Cited by 16 publications

(19 citation statements)

References 11 publications

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“…The safest treatment is micrographic surgery, but many less invasive and non-surgical treatments such as laser ablation, cryotherapy, photodynamic therapy, topical 5-fluorouracil and topical imiquimod have been used in selected cases [4,29,30,31]. However, given the risk of recurrence and in favour of our observation that koilocytes indicative of persistent HPV infection might remain at the margins in micrographic surgery (fig.…”

Section: Discussionmentioning

confidence: 54%

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

et al. 2011

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Background: Bowen’s disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection. Objective: This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition. Methods: Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed. Results: PCR of biopsy specimens revealed in 2 cases infection with HPV-16 and in 1 case with HPV-73. Additionally, in 1 HPV-16-positive case HPV-31/33 was detected by in situ hybridization. In line, review of the literature demonstrated a clear association of HPV-positive BD with high-risk HPV types. Interestingly, age at diagnosis was significantly lower in women. Whereas in both genders the second to fourth fingers on both hands were commonly diseased, only in men the thumbs were also prominently affected. Conclusions: Infection with high-risk HPV types is common in BD of the nail unit suggesting the aetiological cause. Therefore, patients and partners should be closely followed up for digital and genital HPV-associated lesions.

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Section: Discussionmentioning

confidence: 54%

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

et al. 2011

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“…The presence of pigment does not change the prognosis or treatment of BD, so treatment options include those indicated for nonpigmented BD: surgery, cryotherapy, 6 laser ablation, topical imiquimod or 5‐fluorouracil, curettage, electrosurgery and photodynamic therapy 3 . PBD generally has a good prognosis; unfortunately, in this case, the patient’s general condition was poor.…”

Section: Discussionmentioning

confidence: 89%

“… 1 reported PBD as presenting most frequently as a flat or slightly raised, light‐brown plaque, with varying degrees of scaling, occurring more often in men, on the limbs, trunk, head and neck. To our knowledge, there have only been two previous reports of PBD of the umbilicus 2,3 …”

Section: Discussionmentioning

confidence: 98%

A large pigmented lesion mimicking malignant melanoma

Brinca

Teixeira

Gonçalo

2012

Clinical and Experimental Dermatology

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“…PBD outside the anogenital area has been infrequently described in patients with skin types I to IV. Lesions were found on the head, trunk, arms, legs, and fingers 1–3 . In almost all of these cases, malignant melanoma was considered in the differential diagnosis.…”

mentioning

confidence: 99%

“…In later stages of Bowen's disease, the atypical keratinocytes lose this ability, resulting in visible loss of pigmentation, keratosis, and desquamation. Lee and colleagues suggested that, in PBD, specific growth factors or cytokines produced by neoplastic cells may stimulate proliferation of melanocytes and production of melanin 2 . In addition, it has been hypothesized that PBD originates from preexisting solar lentigines and seborrheic keratoses, because several cases of PBD were reported adjacent to or overlapping with these entities 1,7 .…”

mentioning

confidence: 99%