A case of plasmablastic lymphoma diagnosed on liquid‐based pap test

Arce, Julián; Broadway, Kameelah; Somma, Jonathan; Khader, Samer

doi:10.1002/dc.23063

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…14 Plasmablastic lymphoma in the uterus is very rarely reported. After excluding secondary involvement, 15 we identi ed four reported cases of patients aged 47 years 16 , 54 years 17 , 61 years 18 , and 85 years, respectively. 19 Only the 61-year-old patient was HIV-positive, while the others were HIV-negative.…”

Section: Discussionmentioning

confidence: 99%

Transient Atypical Lymphoplasmacytic Proliferation in Endometrium Associated With Pyometra: a Case Report

Otani

Murakami

Kimura

et al. 2021

Preprint

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Background Plasmablastic lymphoma is a mature B-cell neoplasm with plasmablastic differentiation, often associated with human immunodeficiency virus (HIV) infection and other forms of immunosuppression. Although it is usually an aggressive disease, spontaneous regression has been seen in a few cases. Plasmablastic lymphoma in the uterus is rare. Here we report a case of atypical lymphoplasmacytic proliferation resembling plasmablastic lymphoma associated with pyometra that disappeared completely as the pyometra resolved. Case presentation A 76-year-old HIV-negative woman presented with abnormal vaginal bleeding. Ultrasound and MRI findings were consistent with pyometra diagnosis. Endometrial biopsy revealed large plasmablastoid cells with abundant cytoplasms and prominent nucleoli proliferating in the endometrium. Immunohistochemistry showed that large cells stained positive for CD138, CD79a, and MUM1, and negative for CD20, PAX5, CD3, and CD5. Ki67 labelled at least 80% of the large cells. Epstein–Barr virus was detected in a small number of cells. The histological picture was highly indicative of lymphoma, especially plasmablastic lymphoma, though the clinical context was unusual. As the pyometra was treated and resolved, the intrauterine abnormality disappeared completely. The patient has been well after 16 months with no sign of recurrent disease. Conclusions This case underscores the sometimes blurry distinction between benign inflammation and lymphomas.

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Section: Discussionmentioning

confidence: 99%

Transient Atypical Lymphoplasmacytic Proliferation in Endometrium Associated With Pyometra: a Case Report

Otani

Murakami

Kimura

et al. 2021

Preprint

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Cytological features of oral malignant lymphoma in scraping liquid-based cytology: Cases of plasmablastic lymphoma and anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

Oya

Kondô

Kishino

et al. 2023

Annals of Diagnostic Pathology

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Plasmablastic Lymphoma in the Submandibular Region Diagnosed by FNAC: A Case Report and Literature Review

de Aquino,

de Cáceres,

Bezerra

et al. 2024

Cytopathology

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ObjectiveThis study aims to provide a literature review of FNAC‐diagnosed plasmablastic lymphoma (PBL) cases and present a case of PBL in an HIV patient diagnosed by FNAC.MethodsA literature review was conducted across eight databases to compile information on FNAC‐diagnosed PBL cases without restricting the site of involvement.ResultsThe literature review included 23 PBL, with 13 (56.5%) affecting head and neck region. The mean age of patients was 49 years, with a male‐to‐female ratio of 1.9:1, and 13 (56.5%) patients were HIV positive. Ten (43.5%) of 23 patients tested positive for Epstein–Barr virus (EBV). Twenty‐one FNAC procedures and two cytological smears were performed. Plasmacytoid/plasmablastic morphology was described in seven cases (30.4%). Large cells were observed in 17 cases (73.9%). Pleomorphism was noted in 10 cases (43.5%). A cytological diagnosis of malignancy was achieved in 91.3% of cases. In 20 cases assessed for concordance, complete agreement was found in 8 cases (34.8%), while discordance was noted in 12 cases (65.2%). We also report a case of PBL diagnosed via FNAC in a 55‐year‐old male patient who presented with a painful, hard, nonmobile mass in the left submandibular region, approximately 10 cm in size, with 1 month of evolution. FNAC was performed, and cytologic smears, along with cell block (CB) preparations, were made. After staining with Diff‐Quik, HE and Papanicolaou stain, numerous cells exhibiting plasmacytic morphology were observed. Immunohistochemical analysis showed negativity for LCA, CD3, CD20, Pax5, CD79a, ALK and HHV‐8, and positivity for CD138, MUM1 and Ki‐67 (100%). EBV positivity was also confirmed, leading to a diagnosis of PBL.ConclusionThis study highlights the efficacy of FNAC in diagnosing PBL. The immunophenotypic profile and morphological features observed through FNAC, combined with immunohistochemistry (IHC) and in situ hybridisation, were crucial for an accurate diagnosis. The literature review underscores the value of FNAC as a diagnostic tool for PBL, demonstrating a high rate of cytological diagnosis and significant cytohistological concordance.

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A case of plasmablastic lymphoma diagnosed on liquid‐based pap test

Cited by 3 publications

References 10 publications

Transient Atypical Lymphoplasmacytic Proliferation in Endometrium Associated With Pyometra: a Case Report

Transient Atypical Lymphoplasmacytic Proliferation in Endometrium Associated With Pyometra: a Case Report

Cytological features of oral malignant lymphoma in scraping liquid-based cytology: Cases of plasmablastic lymphoma and anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

Plasmablastic Lymphoma in the Submandibular Region Diagnosed by FNAC: A Case Report and Literature Review

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