A case of polymicrogyria in macaque monkey: impact on anatomy and function of the motor system

Schmidlin, Eric; Jouffrais, Christophe; Freund, Patrick; Wannier-Morino, Patrizia; Beaud, Marie-Laure; Rouiller, Eric M.; Wannier, Thierry

doi:10.1186/1471-2202-10-155

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…All measures were taken to minimize pain and constraints on the animals, and their number was also kept as low as possible, in particular using the same cases (namely BDA injections in various motor cortical areas) to study distinct connection/projection systems (Rouiller et al, 1994(Rouiller et al, , 1996(Rouiller et al, , 1998(Rouiller et al, , 1999Liu et al, 2002;Tann e-Gari epy et al, 2002a,b;Freund et al, 2007;Schmidlin et al, 2009;Fregosi et al, 2017;Innocenti et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

Ipsilateral corticotectal projections from the primary, premotor and supplementary motor cortical areas in adult macaque monkeys: a quantitative anterograde tracing study

Fregosi

Rouiller

2017

Eur J of Neuroscience

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The corticotectal projection from cortical motor areas is one of several descending pathways involved in the indirect control of spinal motoneurons. In non-human primates, previous studies reported that cortical projections to the superior colliculus (SC) originated from the premotor cortex (PM) and the primary motor cortex, whereas no projection originated from the supplementary motor area (SMA). The aim of the present study was to investigate and compare the properties of corticotectal projections originating from these three cortical motor areas in intact adult macaques (n = 9). The anterograde tracer biotinylated dextran amine was injected into one of these cortical areas in each animal. Individual axonal boutons, both en passant and terminaux, were charted and counted in the different layers of the ipsilateral SC. The data confirmed the presence of strong corticotectal projections from the PM. A new observation was that strong corticotectal projections were also found to originate from the SMA (its proper division). The corticotectal projection from the primary motor cortex was quantitatively less strong than that from either the premotor or SMAs. The corticotectal projection from each motor area was directed mainly to the deep layer of the SC, although its intermediate layer was also a consistent target of fairly dense terminations. The strong corticotectal projections from non-primary motor areas are in position to influence the preparation and planning of voluntary movements.

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Section: Methodsmentioning

confidence: 99%

Ipsilateral corticotectal projections from the primary, premotor and supplementary motor cortical areas in adult macaque monkeys: a quantitative anterograde tracing study

Fregosi

Rouiller

2017

Eur J of Neuroscience

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“…It was suggested that ischemic infarction or hemorrhage near the time of birth caused the neuroanatomic deficits in this animal. In some colonies of Japanese monkeys, myeloencephalitis with Streptococcus infection (Lair et al 1996), polymicrogyria (Schmidlin et al 2009), neuropathy due to coyotillo intoxication (Joiner et al 1975), multifocal malacia due to Baylisascaris larva migrans (Sato et al 2005), and cerebellar cortical atrophy (Sanford and Mehren 1979) have been reported.…”

Section: Discussionmentioning

confidence: 99%

Cerebromalacia with Epilepsy and Cortical Blindness in a Laboratory Japanese Macaque (Macaca fuscata)

et al. 2010

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The authors performed a pathological examination of a 5-year-old female laboratory Japanese monkey who developed cortical blindness and epileptic seizures. Generalized, tonic-clonic seizures started to occur during behavioral training to get the animal to enter a carrying cage for future psychological experiments. Blindness was suspected because of a lack of approaching behavior toward foods such as fruits. Although the monkey was extensively treated with anticonvulsants, the clinical signs did not improve. An increased serum creatine phosphokinase (CPK) level and bilateral occipital brain atrophy were detected. Histopathologically, a severe degree of cerebromalacia was detected bilaterally in the occipital lobe, and necrosis and gliosis were seen mainly in the temporal lobe. Focal inflammation was found in the meninges. No other changes were observed in other nervous tissues or organs, and no signs of a parasitic or viral infection were found in the systemic organs. Spontaneously occurring lesions in the central nervous system have been rarely reported in laboratory monkeys. In the present case, the cause of cerebromalacia could not be confirmed, but the relationship between symptoms such as abnormal vision and the presence of brain lesions was distinct. The authors believe that this case is a valuable historical control case for the laboratory Japanese macaque.

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Nervous System Disorders of Nonhuman Primates and Research Models

Fahey

Westmoreland

2012

Nonhuman Primates in Biomedical Research

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A case of polymicrogyria in macaque monkey: impact on anatomy and function of the motor system

Cited by 5 publications

References 28 publications

Ipsilateral corticotectal projections from the primary, premotor and supplementary motor cortical areas in adult macaque monkeys: a quantitative anterograde tracing study

Ipsilateral corticotectal projections from the primary, premotor and supplementary motor cortical areas in adult macaque monkeys: a quantitative anterograde tracing study

Cerebromalacia with Epilepsy and Cortical Blindness in a Laboratory Japanese Macaque (Macaca fuscata)

Nervous System Disorders of Nonhuman Primates and Research Models

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