A case of postirradiation angiosarcoma of the greater omentum with hemorrhage

Sakemi, Miyuki; Sakemi, Ryosuke; Harada, Masaru; So, Suketo; Uchiyama, Daiji; Morimitsu, Yosuke; Kakiuchi, Seiya; Ishihara, Yuji; Kubo, Yasuhiko; Matsugaki, Satoru; Ono, Tetujiro; Takane, Junko; Sasaki, Ei; Shimokobe, Masayuki; Sata, Michio

doi:10.1007/s12328-011-0245-6

Cited by 7 publications

(6 citation statements)

References 16 publications

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“…indicated the omentum as the site of origin in three or less cases and Hammer et al identified omental HSA in one case 12–13 . Similarly, omental angiosarcoma is also rare in humans and limited to only two reported cases of spontaneous primary omental angiosarcoma and four reported cases of omental angiosarcoma secondary to previous radiation therapy 15–21 . These patients presented with a variety of signs that ranged from inguinal pain with associated dysuria, nausea, and vomiting to abdominal pain and distention.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13] Similarly, omental angiosarcoma is also rare in humans and limited to only two reported cases of spontaneous primary omental angiosarcoma and four reported cases of omental angiosarcoma secondary to previous radiation therapy. [15][16][17][18][19][20][21] These patients presented with a variety of signs that ranged from inguinal pain with associated dysuria, nausea, and vomiting to abdominal pain and distention. Although the outcome was not available in all cases, prognosis was poor amongst cases in which outcome was reported due to delayed diagnosis and high metastatic rates despite surgical intervention and adjunct chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Omental hemangiosarcoma in five dogs

Chu

Dugat

Nafe

et al. 2021

Vet Record Case Reports

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Five dogs were diagnosed with omental hemangiosarcoma (HSA). Three of the dogs were Schnauzers. One dog was asymptomatic and four dogs presented with urinary or colonic obstruction. Computed tomography, performed in three cases, revealed a well‐circumscribed caudal abdominal mass that displaced local abdominal organs. Surgical exploration confirmed that the masses were associated with the omentum. The mass was removed in four cases and debulked in one. Histopathologic evaluation in all cases was consistent with HSA. One dog underwent adjuvant chemotherapy and survived 170 days, whilst adjuvant chemotherapy was declined in the other cases, with survival times ranging from 50–120 days. Omental HSA can result in clinical signs related to fecal or urinary obstruction due to the size of the mass and caudal location within the abdomen. Although omental HSA is a rare anatomic variant of HSA, it does behave similar to splenic and other visceral HSA, with a guarded prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Omental hemangiosarcoma in five dogs

Chu

Dugat

Nafe

et al. 2021

Vet Record Case Reports

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“…It has also been reported that sarcomas increase their incidence after radiotherapy for prostate carcinoma, being 6% within the radiation field and 2% outside the radiation field ( 11 ). In this regard, few cases of angiosarcoma have been reported following radiotherapy for carcinoma of the prostate ( 12 – 16 ). To the best of our knowledge we describe the first two cases of intra-abdominal angiosarcomas secondary to radiotherapy treatment for prostate carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports

Domínguez

González

2018

mol clin onc

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Angiosarcoma is a rare soft tissue neoplasm, which accounts for <1% of all soft tissue tumours. It has been previously reported that the incidence rate of angiosarcomas increases following radiotherapy. The present study reports two cases of intra-abdominal angiosarcoma associated with previous radiotherapy treatment. To the best of our knowledge, these associations have not been previously described in English literature. The patients aged 71 and 83 years were admitted to the center for abdominal pain and diarrhea. Each patient had previously had treatment with radiotherapy for prostate adenocarcinoma. During their hospitalization, biopsies were obtained and the diagnosis of angiosarcoma was reached. In each patient the tumors had irregular proliferating vascular channels, lined by atypical endothelial cells, which varied from elongated and spindle-shaped to large and plump. Immunocytochemistry revealed that the tumor cells were positive for the cytoplasmic endothelial markers cluster of differentiation (CD)31 and CD34. The recognition of these associations is important and their occurrence in this rare type of neoplasm should not mislead the pathologist and cause a misdiagnosis of the sarcoma.

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“…The clinical presentations of patients with peritoneal angiosarcomas are diverse and non-specific. These include abdominal distention, symptomatic malignant ascites or occasionally patients may present with a perforated viscus or intestinal obstruction 7. Due to these non-specific symptoms, patients tend to be diagnosed at an advanced stage.…”

Section: Discussionmentioning

confidence: 99%

Radiation-associated peritoneal angiosarcoma

et al. 2017

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Angiosarcomas account for only 1-2% of all soft tissue sarcomas, with the most common site of origin being in the head and neck region. Peritoneal angiosarcoma is an extremely rare tumour and few cases have been reported previously. Presentation of peritoneal angiosarcoma can be very variable, hence making diagnosis difficult. Herein, we review the current literature and describe a rare case of a patient who presented with haemorrhagic ascites, 17 years after radiotherapy for endometrial carcinoma and was subsequently diagnosed with peritoneal angiosarcoma. Due to extensive disease, surgery was not a viable option. She was started on palliative chemotherapy, but despite treatment, her condition deteriorated further and she eventually passed away. We highlight the diagnostic challenges and considerations in these patients as well as current treatment and management options available.

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A case of postirradiation angiosarcoma of the greater omentum with hemorrhage

Cited by 7 publications

References 16 publications

Omental hemangiosarcoma in five dogs

Omental hemangiosarcoma in five dogs

Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports

Radiation-associated peritoneal angiosarcoma

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