A Case of Primary Hepatic Lymphoma and Related Literature Review

Abstract

Objective. Primary hepatic lymphoma is a rare disease. And the clinical manifestations of this disease are nonspecific. The objective of this paper is to improve clinicians' understanding of this disease. Methods. We analyzed the clinical characteristics of a case of primary hepatic lymphoma in association with hepatitis B virus infection and reviewed the literature. Conclusion. The clinical manifestations of primary hepatic lymphoma are nonspecific. And it is easily misdiagnosed. Postoperative radiotherapy of patients with early stage was previously speculated to achieve favorable improvement. The application of targeted therapeutic drugs, chemotherapy, or combined local radiotherapy has become the first-line treatment strategy.

Primary Hepatic Lymphoma in a Patient with Chronic Hepatitis B

“…Primary liver non-Hodgkin’s lymphoma is extremely rare, accounting for 0.4% of all primary extranodal lymphoma and 0.016% of all cases of NHL [2]. PHL may occur at any age but is more common in males aged about 50 years.…”

“…Primary hepatic lymphoma (PHL) is a rare disease, with an incidence of only 0.1% of malignant liver tumors. The subtype of diffuse large B-cell lymphoma (DLBCL) is more infrequent [2]. Hepatitis C virus has been the most frequently studied hepatitis virus as a risk factor of lymphoma development.…”

Jaundice may be the only clinical manifestation of primary hepatosplenic diffuse large B-cell lymphoma: a case report and literature review

“… 4 The symptoms are nonspecific, varying from loss of appetite, fatigue, low-grade fever, and night sweats to liver function abnormalities, hepatomegaly, and abdominal pain. 8 The typical radiologic characteristics of the disease are space-occupying lesions in the liver or spleen. 3 Some patients exhibit diffuse lesions, displaying hepatosplenomegaly.…”

Hypercalcemia due to Primary Hepatic Lymphoma

“…Overall, there is no pathognomonic radiographic finding in PHL and therefore biopsy is considered the gold standard for the diagnosis of PHL. FNA should not be performed as the tissue may be necrotic and result in a false-negative result [6, 15]. …”

“…One study from the MD Anderson Cancer Center followed up 24 PHL cases for 20 years. Complete remission was achieved in 85% of cases and event-free 5-year survival rate was 70% [15]. …”