Hypercalcemia due to Primary Hepatic Lymphoma

Hsu, Andrew; Gagnier, Michael; Ryer, Elizabeth; Salhab, Mohamed; Rosmarin, Alan G.

doi:10.1155/2016/1876901

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…A review by Vallet et al [ 23 ] demonstrated that hypercalcemia was independently associated with poor PFS and OS[ 23 ]. Many researchers have reported that 40% of PHL patients have serum calcium abnormality[ 24 , 25 ], but there were only 6 patients diagnosed with hypercalcemia in our study; hence, more data are needed to elucidate its significance in the PHL setting.…”

Section: Discussionmentioning

confidence: 74%

Clinical management and susceptibility of primary hepatic lymphoma: A cases-based retrospective study

Tao¹,

Zou²

2021

WJCC

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BACKGROUND The liver as a primary site of lymphoma is rarely seen, they are usually misdiagnosed as hepatocellular carcinoma, etc . In 2017, a review of primary hepatic lymphoma (PHL) was done in immunocompetent diffuse large B-cell lymphoma (DLBCL) patients. Yet questions that include treatment choosing or susceptibility of immunoincompetent patients remain disputable. AIM To investigate the clinical characteristics of patients with PHL. METHODS We collected PHL cases on PubMed, and extracted demographic and clinicopathological data to perform a systematic analysis. Survival analysis regarding age, lactate dehydrogenase (LDH), liver function abnormality (LFA), and treatment modalities were conducted. The Kaplan-Meier method and Cox regression were used to identify risk factors. RESULTS Of 116 PHL patients with DLBCL (62.1%) as the most common subtype. Biopsy methods before surgery produced a 97% positive rate. Progression-free survival (PFS) was significantly shortened in patients with elevated LDH [Hazard ratio (HR): 3.076, 95% confidence interval (CI): 1.207-7.840, P = 0.018] or LFA (HR: 2.909, 95%CI: 1.135-7.452, P = 0.026). Univariate Cox regression analysis suggesting that LDH, liver function, B symptom, hepatosplenomegaly, and lesion were significantly associated with PHL patients survival ( P < 0.05). Heavy disease burden was observed in deceased patients. A few PHL patients (3.4%) have slightly higher tumor markers. CONCLUSION PHL patients with elevated LDH and LFA tend to have shorter PFS. Biopsy before treatment in undecided patients with no tumor markers exceeds upper limits has the most essential clinical significance, especially in immunoincompetent patients.

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Section: Discussionmentioning

confidence: 74%

Clinical management and susceptibility of primary hepatic lymphoma: A cases-based retrospective study

Tao¹,

Zou²

2021

WJCC

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“…Full blood counts are usually within the normal range unless the bone marrow or spleen is involved ( 38 ). Other occasional laboratory findings include monoclonal paraproteinemia and hypercalcemia, which is possibly the result of the secretion of calcitriol by lymphoma cells ( 39 , 40 ).…”

Section: Primary Hepatic Lymphomamentioning

confidence: 99%

Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management

Wang

Wu²,

Zhang³

et al. 2022

Front. Oncol.

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Primary hepatopancreatobiliary lymphoma (PHPBL) is extremely rare, which is defined as a lympho-proliferative disease confined to the hepatobiliary system and pancreas without any involvement of lymph nodes, bone marrow, or other organs. The clinical and imaging manifestations of PHPBL are variable and non-special, which are akin to those of tumors of the hepatobiliary and pancreatic systems. The overall prognosis and management of PHPBL differ from those of other tumors in the hepatobiliary system and pancreas. Proper diagnosis and prompt treatment are essential for improving clinical outcomes. Due to its rarity, the optimal treatment has not been issued. However, combination chemotherapy is considered as a standard treatment for them. This review provides an overview of the pathogenesis, diagnosis, pathology, and management of PHPBL and offers clinicians the diagnosis and management schedule for PHPBL.

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Hypercalcemia due to Primary Hepatic Lymphoma

Cited by 2 publications

References 15 publications

Clinical management and susceptibility of primary hepatic lymphoma: A cases-based retrospective study

Clinical management and susceptibility of primary hepatic lymphoma: A cases-based retrospective study

Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management

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