A Case of Primary Mucinous Carcinoma of the Scalp Treated With Mohs Surgery

Ortiz, Karem; Gaughan, M. D.; Bang, Ran H.; Padilla, R. Steven; Crooks, Lida

doi:10.1097/00042728-200208000-00022

Cited by 4 publications

(7 citation statements)

References 47 publications

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“…Common sites of involvement are eyelids, cheek and scalp. Other less common sites include axilla, foot, chest wall and vulva 2,3 , 8–10 . The tumour is usually solitary and grows asymptomatically over several months or even years.…”

Section: Discussionmentioning

confidence: 99%

“…The recommended treatment for primary mucinous carcinoma of skin is a wide surgical excision, with magnetic resonance imaging being useful in delineating the margins 5 . Mohs’ micrographic surgery is an alternative method that has been used successfully 2 . The importance of detecting hormone receptors in this tumour lies in the potential of using antioestrogenic drugs like tamoxifen to treat these patients as there is a high rate of local recurrence after surgical excision, especially in anatomical areas where adequate wide excision is not possible, for example, the face.…”

Section: Discussionmentioning

confidence: 99%

“…Primary mucinous adenocarcinoma of the skin is a rare tumour of eccrine gland origin. Since its original description in 1952, approximately 140 cases have been cited in the literature 1–6 . This tumour is morphologically very similar to mucinous carcinoma of the breast.…”

Section: Introductionmentioning

confidence: 99%

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Oestrogen and progesterone receptors in primary mucinous carcinoma of skin

2005

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A 74-year-old man presented with a recurrent indolent growth in the left axilla. Fine-needle aspiration cytology and histopathological examination showed a picture of mucinous adenocarcinoma. Clinical examination and systemic investigations failed to detect any primary lesion elsewhere and hence, a diagnosis of primary mucinous carcinoma of the skin was made. This tumour shows histological resemblance to mucinous carcinoma of breast. We also demonstrated expression of oestrogen and progesterone receptors in this tumour. This observation suggests that there is a potential of using antioestrogenic therapy in patients with primary cutaneous mucinous carcinoma, especially because of its high rate of local recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Oestrogen and progesterone receptors in primary mucinous carcinoma of skin

2005

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“…24 Mohs' micrographic surgery has been proposed as an effective treatment for many authors. 7,[45][46][47][48] The ability of magnetic resonance imaging to obtain images in multiple planes facilitates localization of the tumor and clarifies anatomic relationships, thus it can be helpful in the planning of surgical excision and staging the disease. 11 Fine-needle aspiration biopsy might also be useful in preoperative evaluation.…”

Section: Discussionmentioning

confidence: 99%

Mucinous Carcinoma of the Skin: Evaluation of Lymphatic Invasion With D2-40

Paradela¹,

Castiñeiras²,

Cuevas³

et al. 2008

The American Journal of Dermatopathology

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Primary cutaneous mucinous carcinoma is a rare adnexal sweat gland neoplasm that mainly affects elderly people. Differential diagnosis includes mammary and gastrointestinal metastatic mucinous carcinoma (MC) and secondary cutaneous involvement by underlying neoplasms. An 83-year-old woman presented with an 8-year history of slow-growing infiltrate plaque in her right hemithorax, with ulceration on supraclavicular area, right upper limb edema and palpable axillary lymphadenopathies. She underwent partial excision of the tumor and local radiotherapy. Imaging studies showed widespread cutaneous dissemination with enlargement of ipsilateral axillary lymph nodes but without evidence of underlying breast cancer. Histopathological examination showed large amounts of mucin in the dermis including small islands of epithelial cells. They stained positive for cytokeratin 7, carcinoembryonic antigen, epithelial membrane antigen, gross cystic disease fluid protein-15, and c-erbB-2. Lymphatic invasion was demonstrated by D2-40-immunostained sections. A diagnosis of primary cutaneous mucinous carcinoma was made. Our aim was to reevaluate the differential clinical, histopathological, and immunohistochemical criteria for distinguishing primary cutaneous mucinous carcinoma from skin metastases of visceral mucinous carcinoma, especially those arising in breast. We also propose D2-40 as a reliable marker to detect lymphatic invasion that indicates a strong aggressive trend with shorter recurrence-free and predicts nodal metastases.

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“…39,49,56 Six previously reported cases of MEA treated with MMS pooled from the work of 5 different authors suggest no local recurrence after MMS with a follow-up time ranging from 2 to 5 years after MMS. 15,27,39,49,56 However, both patients in our series who were treated with MMS had local recurrence after MMS with clear margins. This suggests that local recurrence is still a concern despite the use of MMS.…”

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confidence: 99%