A case of primary rhabdomyosarcoma of the breast

Attili, Venkata Satya Suresh; Dadhich, H.; RamaRao, Clementeena; Bapsy, P. P.; Ramachandra, C.; Anupama, G.

doi:10.1007/s12262-007-0022-4

Cited by 6 publications

(5 citation statements)

References 3 publications

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“…Our experience regarding RMS cases suggests that spindle cell or small round cell malignancies in the breasts of young females should be suspected of being primary or secondary RMSs. This is the second report that describes a case of ssRMS of the breast, and it may help clinicians who encounter this rare disease in the future [5,7,9,10,12,14,18-31].…”

Section: Discussionmentioning

confidence: 99%

“…This is the second report that describes a case of ssRMS of the breast, and it may help clinicians who encounter this rare disease in the future. 5,7,9,10,12,14,[18][19][20][21][22][23][24][25][26][27][28][29][30][31]…”

Section: Orcidmentioning

confidence: 99%

“…Rhabdomyosarcoma (RMS) is one of the most common sarcomas in young patients; however, RMS of the breast origin is very rare, with only 26 cases reported in international journals [5-7]. Among the reported cases, alveolar subtype was most common, followed by embryonal, spindle cell/sclerosing, and pleomorphic subtypes.…”

mentioning

confidence: 99%

“…[2][3][4] Rhabdomyosarcoma (RMS) is one of the most common sarcomas in young patients; however, RMS of the breast origin is very rare, with only 26 cases reported in international journals. [5][6][7] Among the reported cases, alveolar subtype was most common, followed by embryonal, spindle cell/sclerosing, and pleomorphic subtypes. Spindle cell/sclerosing RMS (ssRMS) is a new subtype of RMS included in the World Health Organization Classification of Tumors of Soft Tissue and Bone in 2013, 8 and only one primary breast ssRMS has been reported in an international journal.…”

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confidence: 99%

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Primary Rhabdomyosarcoma of the Breast: Study of Three Cases at One Institution with a Review of Primary Breast Sarcomas

Shin

Kim

et al. 2019

J Pathol Transl Med

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BackgroundPrimary breast sarcoma (PBS) is rare, comprising approximately 1% of breast malignancies. Rhabdomyosarcoma (RMS) accounts for an extremely small proportion of PBSs, often leading to delayed histologic confirmation.MethodsUpon reviewing Asan Medical Center’s pathology database between 2000 and 2018, 41 PBS cases were retrieved, including three cases of primary RMS of the breast. Their clinicopathological features were analyzed, and the literature related to PBS and primary RMS of the breast was reviewed.ResultsWe identified three primary breast RMS cases from our institution database, comprising 7.3% of PBS: one case each of spindle cell/sclerosing RMS (ssRMS), alveolar RMS (aRMS), and embryonal RMS (eRMS). All cases involved adolescents or young adults (14, 16, and 25 years, respectively) who underwent mastectomy or radiotherapy and were confirmed using immunohistochemical testing for myogenin, desmin, and myogenic differentiation. The ssRMS patient experienced recurrence at the operation site 4 months post-surgery despite undergoing concurrent chemoradiotherapy. The aRMS patient had multiple metastases at diagnosis and showed FAX3-FOXO1 fusion transcripts; she died 22 months after the diagnosis. The eRMS patient had enlarged axillary lymph nodes; post-radiotherapy, the lesion recurred as multiple metastases to the bone and lung. She died 18 months post-diagnosis.ConclusionsOur experience on RMS cases suggests that spindle cell or small round cell malignancy in breasts of young female should raise suspicion for the possibility of primary or secondary RMS. To our knowledge, this is the second report of primary breast ssRMS and it may help clinicians who encounter this rare disease in the future.

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Section: Discussionmentioning

confidence: 99%

Section: Orcidmentioning

confidence: 99%

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confidence: 99%

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Primary Rhabdomyosarcoma of the Breast: Study of Three Cases at One Institution with a Review of Primary Breast Sarcomas

Shin

Kim

et al. 2019

J Pathol Transl Med

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“…A case of a 66-year-old woman with two different solid primary cancers (breast and RMS) with synchronous bone marrow metastases has recently been reported in the literature [10]. To the best of our knowledge, there are only nine cases of primary RMS of the breast in adults, reported in international journals [1, 2, 11–16]. A summarizing table of these cases is provided, including ours (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Primary Alveolar Rhabdomyosarcoma of the Breast in an Adult: An Extremely Rare Case

Trihia

Novkovic

Provatas

et al. 2019

Case Reports in Pathology

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Sarcomas of the breast constitute less than 1% of all malignant breast tumors and primary rhabdomyosarcoma (RMS) is a very rare entity with limited case reports in the literature. RMS is common in children and adolescents and rare in adults. Primary RMS arising from the breast is exceedingly rare in adults. We report a case of a primary RMS of the breast in a 60-year-old woman, who presented in an early stage, mimicking invasive ductal carcinoma clinically and is in complete remission after three years of diagnosis and one year of treatment.

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Breast Metastases in Children and Adolescents With Rhabdomyosarcoma: A Large Single-Institution Experience and Literature Review

Kebudi

Koç²,

Görgün

et al. 2017

Journal of Pediatric Hematology/Oncology

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A case of primary rhabdomyosarcoma of the breast

Abstract: Primary rhabdomyosarcoma of the breast is a rarely reported in adults, and it occurrence is mostly observed in children. We report a case of primary rhabdomyosarcoma of breast in a 40-year-old lady, who presented in early stage and is in complete remission after one year of treatment.

Cited by 6 publications

References 3 publications

Primary Rhabdomyosarcoma of the Breast: Study of Three Cases at One Institution with a Review of Primary Breast Sarcomas

Primary Rhabdomyosarcoma of the Breast: Study of Three Cases at One Institution with a Review of Primary Breast Sarcomas

Primary Alveolar Rhabdomyosarcoma of the Breast in an Adult: An Extremely Rare Case

Breast Metastases in Children and Adolescents With Rhabdomyosarcoma: A Large Single-Institution Experience and Literature Review

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