A case of primary Sjögren’s syndrome presenting primarily with central nervous system vasculitic involvement

Hasıloğlu, Zehra Işık; Albayram, Sait; Tasmali, Koray; Erer, Burak; Selçuk, Hakan; Işlak, Civan

doi:10.1007/s00296-011-1824-z

Cited by 21 publications

(14 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While callosal lesions may occur,70 71 they are relatively infrequent68 69 72 compared with MS. In one study, CC/subcallosal lesions were present in only 8% of patients with SLE or Sjogren's syndrome,58 and in another study, only 3 out of 25 patients with Sjogren's syndrome with white matter abnormalities had CC involvement 69.…”

Section: Non-demyelinating Neuroinflammatory Diseasesmentioning

confidence: 99%

The corpus callosum in the diagnosis of multiple sclerosis and other CNS demyelinating and inflammatory diseases

Garg

Miller

et al. 2015

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

Lesions in the corpus callosum (CC) are important radiological clues to the diagnosis of multiple sclerosis (MS), but may also occur in other neuroinflammatory and non-neuroinflammatory conditions. In this article, we discuss the radiological features of lesions within the CC in MS and other central nervous system inflammatory and acquired demyelinating diseases. An understanding of the appearance and location of lesions in the CC is important not only for accurate diagnosis and treatment of these various conditions, but as it also provides insights into pathogenesis.

show abstract

Section: Non-demyelinating Neuroinflammatory Diseasesmentioning

confidence: 99%

The corpus callosum in the diagnosis of multiple sclerosis and other CNS demyelinating and inflammatory diseases

Garg

Miller

et al. 2015

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

show abstract

“…In our research, the main neurological manifestation at the beginning was headache in both kinds of vasculitides, though severe headache was more commonly observed in PCNSV. Although headache is a nonspecific symptom for ARD, CNS vasculitis should be searched for these patients if they present it [17][18][19][20][21][22]. In our study, focal and non-focal neurological manifestations were similar in both groups of vasculitides, except for the focal motor deficit which was significantly more frequent in PCNSV.…”

Section: Discussionmentioning

confidence: 44%

Primary and secondary central nervous system vasculitis: clinical manifestations, laboratory findings, neuroimaging, and treatment analysis

et al. 2014

View full text Add to dashboard Cite

The objectives of this study are to compare the initial clinical, laboratory, and imaging features in primary central nervous system vasculitis (PCNSV) vs secondary central nervous system vasculitis (SCNSV) and follow up after treatment with intravenous cyclophosphamide (IV-CYC) plus glucocorticosteroids (GCS): methylprednisolone (MP). Neurological, laboratory, and neuroimaging findings were analyzed in PCNSV and SCNSV patients. Cerebral biopsy (CB) was performed in nine patients. Both groups received at onset MP plus IV-CYC for 6 months, followed by bimonthly IV-CYC plus prednisone (PND) for 12 months. All patients were followed during 36 months. Thirty patients were included (12 PCNSV and 18 SCNSV). Focal and non-focal neurological manifestations were similar in both groups, headache being the most frequent manifestation in both groups. Fatigue, myalgias, arthralgias, neuropathy, low leukocytes and platelets, elevated erythrocyte sedimentation rate, positive antinuclear antibodies (ANA), anti-double-stranded DNA (dsDNA), antineutrophil cytoplasmic antibodies (ANCA), low complement, and rheumatoid factor were more frequent in SCNSV (p < 0.05). In cerebrospinal fluid, pleocytosis and proteins were higher in PCNSV (p < 0.05). Periventricular and subcortical hyperintense lesions were observed in cranial magnetic resonance imaging in both vasculitides. Cerebral angiography and angioresonance showed narrowing of vasculature in all patients in both groups. CB showed gliosis and lymphocytic infiltration within and around the walls in four patients and granulomatous infiltration in the other patients. After treatment, the Kaplan-Meier survival curve showed a higher relapse-free survival in PCNSV (p < 0.05). Neurological manifestations and neuroimaging findings were similar in both groups of vasculitides, but general symptoms, joint, musculoskeletal, and peripheral neuropathy were preponderant in SCNSV. After treatment with IV-CYC and GCS, patients with PCNSV had a higher relapse-free survival than those with SCNSV.

show abstract

“…However, pSS is not a vasculitic disease, although sometimes small vessel vasculitis may occur in cases with high disease activity. Vasculitis of larger vessels is only occasionally described in cerebral angiography studies in patients with pSS . Another factor weighing against vasculitis as a pathogenic player is our previous finding that the pSS patients do not have more cerebral infarcts or higher WMH scores than age‐ and gender‐matched healthy subjects .…”

Section: Discussionmentioning

confidence: 98%

Loss of cerebral white matter in primary Sjögren's syndrome: a controlled volumetric magnetic resonance imaging study

Lauvsnes

Beyer

Appenzeller

et al. 2014

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

A case of primary Sjögren’s syndrome presenting primarily with central nervous system vasculitic involvement

Cited by 21 publications

References 12 publications

The corpus callosum in the diagnosis of multiple sclerosis and other CNS demyelinating and inflammatory diseases

The corpus callosum in the diagnosis of multiple sclerosis and other CNS demyelinating and inflammatory diseases

Primary and secondary central nervous system vasculitis: clinical manifestations, laboratory findings, neuroimaging, and treatment analysis

Loss of cerebral white matter in primary Sjögren's syndrome: a controlled volumetric magnetic resonance imaging study

Contact Info

Product

Resources

About