A case of primary thyroid squamous cell cancer: transformation from benign tumour associated with chronic thyroiditis?

Kondo, Tatsuya; Matsuyoshi, Akiko; Matsuyoshi, Hidetake; Goto, Rieko; Ono, Kaoru; Honda, Yumi; Iyama, Ken Ichi; Tsuruzoe, Kaku; Miyamura, Nobuhiro; Araki, Eiichi

doi:10.1136/bcr.10.2008.1137

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…The imaging findings of PSCCT have seldom been published. Regarding US findings, PSCCT has been reported to be a nodule with eggshell calcification and peripheral soft tissue [ 8 ], or as a slowly growing, irregularly marginated hypoechoic solid nodule [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of thyroid gland with local recurrence: ultrasonographic and computed tomographic findings

et al. 2014

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Primary squamous cell carcinoma of the thyroid gland (PSCCT) is a rare malignancy that presents with advanced disease and poor prognosis. It is difficult to diagnose PSCCT in its early stage because of its rarity and lack of typical imaging findings. We experienced an elderly woman with PSCCT confirmed by surgery. Although preoperative fine-needle aspiration revealed no malignancy, surgical resection was performed because the ultrasonogram showed diffuse microcalcifications, which suggested malignancy, and clinically, the mass grew rapidly to compress the trachea. Local tumor recurrence was noted at 3 months after surgery. Surgical resection or repeat biopsy should be considered if a cytologically benign thyroid mass shows imaging or clinical features of malignancy.

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Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of thyroid gland with local recurrence: ultrasonographic and computed tomographic findings

et al. 2014

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“…In the case of Jang et al ( 7 ), ThyPSCC presented as a large, well-defined, lobulated, heterogeneously hypoechoic mass with diffuse microcalcifications on ultrasonography. Kondo et al ( 18 ) reported that a well-differentiated ThyPSCC showed a cystic hypoechoic mass with a smooth margin and rapidly grew with margin change blurring in 1 year. In our case, this poorly differentiated ThyPSCC presented as a solitary marked hypoechoic thyroid mass with an irregular margin and unclear boundary with a normal thyroid.…”

Section: Discussionmentioning

confidence: 99%

Contrast-Enhanced Ultrasound of Primary Squamous Cell Carcinoma of the Thyroid: A Case Report

et al. 2020

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Introduction: Primary squamous cell carcinoma of the thyroid (ThyPSCC) is an extremely rare aggressive malignancy with a poor prognosis. However, almost no report thus far has investigated the microvasculature of ThyPSCC imaged using contrast-enhanced ultrasound. Case Report: A 59-year-old male patient presented to our hospital with progressively worsening hoarse voice symptoms for 20 days and was diagnosed with left unilateral vocal fold palsy. Ultrasonography revealed a solitary marked hypoechoic thyroid nodule with an unclear boundary in the inferior part of the left lobe. Color Doppler flow imaging showed a poor blood flow signal inside this nodule. Contrast-enhanced ultrasound images showed a persistent low peak enhancement of the nodule from its periphery to its center. The time-intensity curve displayed a wash-in time of 10 s, a time to peak of 37 s, a peak signal intensity of 24.5%, and a wash-out time of 70 s for the thyroid tumor. Finally, left hemithyroidectomy of the thyroid tumor was performed, and histopathologic and immunohistochemical evaluations confirmed the diagnosis of ThyPSCC. Postoperatively, the patient received a combination therapy of chemotherapy, radiotherapy, and targeted therapy, but the patient died 4 months after surgery. Conclusion: Primary squamous cell carcinoma of the thyroid is a rare but aggressive malignancy of the thyroid. Herein, we reported a case of ThyPSCC and its ultrasonography and pathologic findings.

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To diagnose primary and secondary squamous cell carcinoma of the thyroid with ultrasound malignancy risk stratification

Zhang,

Wei,

Nong

et al. 2024

Front. Endocrinol.

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ObjectivesThis study aimed to investigate the clinico-ultrasound features of primary squamous cell carcinoma of the thyroid (PSCCT) and secondary SCCT (SSCCT) and evaluate the accuracy of fine needle aspiration (FNA) recommendation for SCCT with American College of Radiology-Thyroid Imaging and Reporting Data System (ACR-TIRADS) and Chinese-TIRADS (C-TIRADS).Materials and methodsWe retrieved 26 SCCT patients (11 PSCCT, 15 SSCCT) from our hospital’s pathology database (5,718 patients with thyroid malignancy) over 23 years. Medical records and ultrasound data of the 26 patients with 27 SCCTs were analyzed retrospectively, and each SCCT focus was categorized based on the two TIRADSs.ResultsFor 26 patients (21 males, 5 females) with an age range of 42-81 years, rapidly enlarging thyroid/neck nodules (18/26, 69.2%), dysphagia (7/26, 26.9%), hoarseness (6/26, 23.1%), dyspnea (5/26, 19.6%), cough (4/26, 15.4%), neck pain (2/26, 7.7%), B symptoms (2/26, 7.7%), and blood in sputum (1/26, 3.8%) were presented at diagnosis. Five asymptomatic patients (5/26, 19.2%) were detected by ultrasound. Hoarseness was more common in PSCCT (5/11, 45.5%) than in SSCCT (1/15, 6.7%) (P=0.032). For 27 SCCTs with a mean size of 3.7 ± 1.3 cm, the ultrasound features consisted of solid (25/27, 92.6%) or almost completely solid composition (2/27, 7.4%), hypoechoic (17/27, 63%) and very hypoechoic echogenicity (10/27, 37%), irregular/lobulated margin with extra-thyroidal extension (27/27, 100%), taller-than-wide shape (13/27, 48.1%), punctate echogenic foci (6/27, 22.2%), hypervascularity (23/27, 85.2%) and involved neck lymph (13/26, 50.0%). A total of 27 SCCTs were evaluated as high malignancy risk stratification (≥TR4 and 4B) by the two TIRADSs and recommended FNA in 96.3–100% (26/27, 27/27). Pathologically, more than half of PSCCTs (7/12, 58.3%) and a quarter of SSCCTs (4/15, 26.7%) were poorly differentiated, while moderately and well-differentiated grades were observed in 5 PSCCTs and 11 SSCCTs (P=0.007). Thirteen patients (50.0%) underwent surgery with radical operation in 5 cases (5/13, 38.5%).ConclusionSCCT is an extremely rare and aggressive malignancy with a male predominance. PSCCT and SSCCT had similar clinical and ultrasound features except for tumor differentiation and the symptom of hoarseness. SCCT showed a high malignancy risk stratification in ACR-TIRADS and C-TIRADS, with a high rate of FNA recommendation.

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A case of primary thyroid squamous cell cancer: transformation from benign tumour associated with chronic thyroiditis?

Cited by 5 publications

References 21 publications

Primary squamous cell carcinoma of thyroid gland with local recurrence: ultrasonographic and computed tomographic findings

Primary squamous cell carcinoma of thyroid gland with local recurrence: ultrasonographic and computed tomographic findings

Contrast-Enhanced Ultrasound of Primary Squamous Cell Carcinoma of the Thyroid: A Case Report

To diagnose primary and secondary squamous cell carcinoma of the thyroid with ultrasound malignancy risk stratification

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