Abstract:Primary squamous cell carcinoma of the thyroid gland (PSCCT) is a rare malignancy that presents with advanced disease and poor prognosis. It is difficult to diagnose PSCCT in its early stage because of its rarity and lack of typical imaging findings. We experienced an elderly woman with PSCCT confirmed by surgery. Although preoperative fine-needle aspiration revealed no malignancy, surgical resection was performed because the ultrasonogram showed diffuse microcalcifications, which suggested malignancy, and cli… Show more
HighlightsRare malignancy with poor prognosis.Survival only achieved in early stages with complete resection in combination with adjuvant therapy.Treatment analog to anaplastic thyroid cancer.
HighlightsRare malignancy with poor prognosis.Survival only achieved in early stages with complete resection in combination with adjuvant therapy.Treatment analog to anaplastic thyroid cancer.
“…In this case, positivity for CK5/6 and EMA and negativity for TTF-1 and TG expression predicted squamous cell carcinoma derivation and excluded the possibility of these common tumors (3,21). Further positivity for p63 and Ki67 expression as poor prognostic markers was associated with its poorly differentiated tumor grade (7,22).…”
Section: Discussionmentioning
confidence: 58%
“…To our knowledge, no reports on CEUS imaging findings of ThyPSCC have appeared in the English-language literature. According to Jang et al (7), ThyPSCC showed a large heterogeneously enhancing thyroid mass with a large central non-enhancing portion on enhanced CT, which corresponded well with the squamous cell carcinoma portion with a necrotic portion in pathologic staining. Because of the rapid growth of squamous tumor cells, relatively few interstitial blood vessels in tumors were related to the low peak signal intensity and low AUC on CEUS.…”
Section: Discussionmentioning
confidence: 97%
“…Primary squamous cell carcinoma of the thyroid (ThyPSCC) is a rare thyroid malignancy with high aggressiveness and poor prognosis, comprising ∼0.1-1% of all primary thyroid carcinomas (1)(2)(3)(4)(5)(6). Owing to the rapidly progressing and highly invasive nature of the malignancy, patients with ThyPSCC often present at an advanced stage and are difficult to diagnose in the early stage because of its rare incidence and lack of typical imaging findings (7,8).…”
Introduction: Primary squamous cell carcinoma of the thyroid (ThyPSCC) is an extremely rare aggressive malignancy with a poor prognosis. However, almost no report thus far has investigated the microvasculature of ThyPSCC imaged using contrast-enhanced ultrasound. Case Report: A 59-year-old male patient presented to our hospital with progressively worsening hoarse voice symptoms for 20 days and was diagnosed with left unilateral vocal fold palsy. Ultrasonography revealed a solitary marked hypoechoic thyroid nodule with an unclear boundary in the inferior part of the left lobe. Color Doppler flow imaging showed a poor blood flow signal inside this nodule. Contrast-enhanced ultrasound images showed a persistent low peak enhancement of the nodule from its periphery to its center. The time-intensity curve displayed a wash-in time of 10 s, a time to peak of 37 s, a peak signal intensity of 24.5%, and a wash-out time of 70 s for the thyroid tumor. Finally, left hemithyroidectomy of the thyroid tumor was performed, and histopathologic and immunohistochemical evaluations confirmed the diagnosis of ThyPSCC. Postoperatively, the patient received a combination therapy of chemotherapy, radiotherapy, and targeted therapy, but the patient died 4 months after surgery. Conclusion: Primary squamous cell carcinoma of the thyroid is a rare but aggressive malignancy of the thyroid. Herein, we reported a case of ThyPSCC and its ultrasonography and pathologic findings.
“…The final diagnosis of PSCT should be made after the comprehensive consideration based on the combination of clinical, radiographic, pathologic and immunohistochemical results. Radiologically, PSCT is lack of specific findings [2,7]. Immunohistochemistry is essential for differential diagnosis.…”
Primary Squamous Carcinoma of Thyroid(PSCT) is a rare but distinct clinicopathological disease. Due to the paucity, optimal intervention strategy has not been established yet. PSCT was once viewed as radioresistant. Here we present a rare case of PSCT in which postoperative radiotherapy was effective for local control and maintenance of progression free survival (PFS) of more than 10 months after R2 resection. Our case will help to identify the role of adjuvant radiotherapy in the treatment of PSCT and extend our understanding of this rare thyroid carcinoma.
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