A case of pure endophytic squamous cell carcinoma of the gallbladder: a rare entity with aggressive behaviour

Khan, Nazoora; Afroz, Nishat; Haider, Nazima; Khan, Mohammad Amanullah

doi:10.5146/tjpath.2012.01122

Cited by 7 publications

(13 citation statements)

References 5 publications

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“…Gallbladder carcinoma (GBC) is a common type of cancer in the gastrointestinal tract, and adenocarcinoma (AC) is the most common type of gallbladder cancer[1]. Squamous cell carcinoma (SCC) is a rare subtype and is responsible for only 2%-3% of gallbladder malignancies[2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Squamous cell carcinoma (SCC) is a rare subtype and is responsible for only 2%-3% of gallbladder malignancies[2,3]. Due to its rapid development, the majority of patients with gallbladder SCC (GBSCC) initially present with an advanced stage of the disease and hence a poor prognosis[1]. Although patients underwent surgical interventions, the 5-year survival rate remained at approximately 1%.…”

Section: Introductionmentioning

confidence: 99%

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Pure squamous cell carcinoma of the gallbladder locally invading the liver and abdominal cavity: A case report and review of the literature

Jin

Zhang

Wei

et al. 2019

WJCC

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BACKGROUNDGallbladder squamous cell carcinoma (GBSCC) is a rare subtype of malignancy and accounts for only 2%-3% of gallbladder malignancies. Due to its rapid development, most patients with GBSCC initially present with an advanced stage of the disease and hence a poor prognosis. The clinicopathological and biological features of SCC remain to be fully elucidated, owing to its uncommon occurrence. The majority of currently available data only described individual case reports or series analyses of trivial cases.CASE SUMMARYA 64-year-old man was admitted for progressively poor abdominal distension and pain. Liver computed tomography (CT) showed infiltration of gallbladder carcinoma into the adjacent liver, and enlarged retroperitoneal lymph nodes. The patient underwent radical cholecystectomy. Part of the mass was grey and soft, and the neoplastic section showed a purulent-necrotic lesion. Hematoxylin and eosin staining revealed a moderately differentiated SCC. Immunohistochemical studies showed strong staining of the tumor for AE1/3 and CK5/6. Staining for CK19, CK7, and CAM5.2 was positive in the cytoplasm. Systemic chemotherapy was not administered because of the patient’s poor physical condition. After five months, CT and magnetic resonance cholangiopancreatography showed multiple metastases in the liver and abdominal cavity.CONCLUSIONSquamous components of GBSCC may explain the complex biological behavior, and CD109 may be involved in the pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pure squamous cell carcinoma of the gallbladder locally invading the liver and abdominal cavity: A case report and review of the literature

Jin

Zhang

Wei

et al. 2019

WJCC

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“…(2013) [6] 4 (SCC) 10 (ASC a ) Median of 49 1:2.5 (M:F) Abdominal pain, emesis, and palpable RUQ mass Imaging was performed but findings are not reported Dx: Staging laparoscopy and tumor resection SCC/ASC stage T3 (43%) or T4 (57%) Local invasion of the duodenum, CBD, liver, and colon Median of 28 Khan et al. (2012) [9] 1 35 F R-sided abdominal pain, palpable RUQ mass CT/US: Enlarged GB up to 8.4 cm, thickened GB wall up to 0.8 cm, an 8-cm solid hepatic mass within the right hepatic lobe, and cholelithiasis Dx: Cholecystectomy and partial hepatectomy Pure SCC stage T4N0Mx Local invasion of the liver and omentum Not reported Mghirbi et al. (2016) [5] 1 67 F RUQ pain, 15 kg weight loss, and palpable RUQ mass CT: 8-cm solid cystic mass of the GB bed with intrinsic calcifications and extension into the adjacent liver parenchyma US: 10-cm heterogeneous GB mass with echogenic center and hepatic invasion Dx: Colonoscopic biopsy of a right colon lesion SCC of the GB (R colon biopsy) T4NxMx Local invasion of the liver and right colon Not reported Roa et al.…”

Section: Discussionmentioning

confidence: 99%

A case of primary squamous cell carcinoma of the gallbladder with local invasion of the liver and peritoneum, and metastasis to the omentum

Levy

Casalduc-Coca

Asiry

et al. 2018

Radiology Case Reports

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Primary squamous cell carcinoma of the gallbladder is a rare entity that comprises approximately 1%-3% of all primary gallbladder cancers. We report the case of a 37-year-old woman who was diagnosed with a locally invasive squamous cell carcinoma of the gallbladder. Surgical pathology revealed a predominantly squamous cell carcinoma composition of the tumor with a few microscopic foci of adenocarcinoma (<1% of tumor). We discuss pertinent clinical features, risk factors, and imaging characteristics to prompt early diagnosis and treatment, which will ultimately lead to improved patient outcomes.

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“…In the early stages, cholecystectomy may be adequate. Late stages with local invasion may require radical dissection [ 2 , 10 ]. Metastatic disease and peritoneal dissemination are poor prognostic factors and such cases are not amenable to surgical resection.…”

Section: Discussionmentioning

confidence: 99%

Primary Pure Squamous Cell Carcinoma of the Gallbladder Locally Invading the Liver, Duodenum, and Stomach: A Case Report and Literature Review

Alpuerto

Mora

Robitsek

et al. 2017

Case Reports in Surgery

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Primary pure squamous cell carcinoma (SCC) of the gallbladder is an exceptionally rare type of tumor that comprises only 1% of all gallbladder cancer. SCC of the gallbladder portends a worse prognosis than the more common adenocarcinoma variant because of its aggressive invasion to local structures and because it is often diagnosed at an advanced stage. Owing to its rarity, diagnosis and management can be challenging. Herein, we present the case of a 75-year-old female complaining of abdominal pain, nausea, and vomiting. Computed tomography and ultrasonography results of the abdomen were consistent with acute cholecystitis and cholelithiasis. Histologic evaluation of the resected mass revealed a malignant tumor with prominent keratinization, confirming the diagnosis of an invasive primary pure SCC of the gallbladder. Microscopic examination showed direct infiltration to the liver, duodenum, and stomach. This case report describes the hospital course of a patient with SCC of the gallbladder and suggests that gallbladder cancer should be considered as part of the differential diagnosis in elderly patients presenting with acute cholecystitis. In addition, this article will review existing literature to examine the utility of different diagnostic techniques and treatment modalities available in the management of gallbladder cancer.

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A case of pure endophytic squamous cell carcinoma of the gallbladder: a rare entity with aggressive behaviour

Cited by 7 publications

References 5 publications

Pure squamous cell carcinoma of the gallbladder locally invading the liver and abdominal cavity: A case report and review of the literature

Pure squamous cell carcinoma of the gallbladder locally invading the liver and abdominal cavity: A case report and review of the literature

A case of primary squamous cell carcinoma of the gallbladder with local invasion of the liver and peritoneum, and metastasis to the omentum

Primary Pure Squamous Cell Carcinoma of the Gallbladder Locally Invading the Liver, Duodenum, and Stomach: A Case Report and Literature Review

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