A case of pyometrocolpos with Bifidobacterium species

Bhaskar, Maanasa; Sistla, Sujatha; Kumaravel, S

doi:10.1016/j.anaerobe.2017.01.007

Cited by 8 publications

(6 citation statements)

References 16 publications

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“…Finally, in the absence of Lactobacillus , Bifidobacterium are hypothesised to be able to maintain healthy vaginal balance by the production of lactic acid [ 21 , 33 ]. However, our results show a negative association of Bifidobacterium with LB, in agreement with other reports demonstrating Bifidobacterium species to be pathogenic in various infectious conditions [ 6 , 10 , 47 ].…”

Section: Discussionsupporting

confidence: 93%

Endometrial microbiota composition is associated with reproductive outcome in infertile patients

et al. 2022

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Background Previous evidence indicates associations between the female reproductive tract microbiome composition and reproductive outcome in infertile patients undergoing assisted reproduction. We aimed to determine whether the endometrial microbiota composition is associated with reproductive outcomes of live birth, biochemical pregnancy, clinical miscarriage or no pregnancy. Methods Here, we present a multicentre prospective observational study using 16S rRNA gene sequencing to analyse endometrial fluid and biopsy samples before embryo transfer in a cohort of 342 infertile patients asymptomatic for infection undergoing assisted reproductive treatments. Results A dysbiotic endometrial microbiota profile composed of Atopobium, Bifidobacterium, Chryseobacterium, Gardnerella, Haemophilus, Klebsiella, Neisseria, Staphylococcus and Streptococcus was associated with unsuccessful outcomes. In contrast, Lactobacillus was consistently enriched in patients with live birth outcomes. Conclusions Our findings indicate that endometrial microbiota composition before embryo transfer is a useful biomarker to predict reproductive outcome, offering an opportunity to further improve diagnosis and treatment strategies.

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Section: Discussionsupporting

confidence: 93%

Endometrial microbiota composition is associated with reproductive outcome in infertile patients

et al. 2022

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“…Finally, in the absence of Lactobacillus, Bifidobacterium are hypothesised to be able to maintain healthy vaginal balance by the production of lactic acid (Freitas and Hill 2017; Kyono et al 2019). However, our results show a negative association of Bifidobacterium with LB, in agreement with other reports demonstrating Bifidobacterium species to be pathogenic in various infectious conditions (Bhaskar, Sistla, and Kumaravel 2017; Pathak, Trilligan, and Rapose 2014; Y. Chen et al 2019).…”

Section: Discussionsupporting

confidence: 93%

Endometrial microbiota composition is associated with reproductive outcome in infertile patients

Moreno

García-Grau

Pérez-Villaroya

et al. 2021

Preprint

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Background: Previous evidence indicates associations between the female reproductive tract microbiome composition and reproductive outcome in infertile patients undergoing assisted reproduction. We aimed to determine whether the endometrial microbiota composition is associated with reproductive outcomes of live birth, biochemical pregnancy, clinical miscarriage, or no pregnancy. Methods: Here we present a multicentre prospective observational study using 16S rRNA gene sequencing to analyse endometrial fluid and biopsy samples before embryo transfer in a cohort of 342 infertile patients asymptomatic for infection undergoing assisted reproductive treatments. Results: A dysbiotic endometrial microbiota profile composed of Atopobium, Bifidobacterium, Chryseobacterium, Gardnerella, Haemophilus, Klebsiella, Neisseria, Staphylococcus and Streptococcus was associated with unsuccessful outcomes. In contrast, Lactobacillus was consistently enriched in patients with live birth outcomes. Conclusions: Our findings indicate that endometrial microbiota composition before embryo transfer is a useful biomarker to predict reproductive outcome, offering an opportunity to further improve diagnosis and treatment strategies.

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“…It has been hypothesized that Bifidobacterium might be able to guarantee a healthy vaginal balance by the production of lactic acid, in the lack of Lactobacillus. However, there are several cases reporting Bifidobacterium species as pathogens in various infectious conditions [49,50], and a high level of stress inducers has been detected in vaginal epithelial cells when Bifidobacterium predominated the VMB [38]. Hence, the role of members of this genus should be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Association between the vaginal microbiome and high-risk human papillomavirus infection in pregnant Chinese women

et al. 2019

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Background: In this study, the association between high-risk human papillomavirus (hrHPV) infection and the vaginal microbiome in pregnant women was evaluated in Chinese cohorts. Methods: The vaginal bacterial composition of four groups, 38 hrHPV-infected pregnant women (PHR, n = 38), pregnant women without HPV infection (PN, n = 48), nonpregnant women with hrHPV infection (NPHR, n = 19) and nonpregnant women without HPV infection (NPN, n = 30), was characterized by deep sequencing of barcoded 16S rRNA gene fragments (V3-4) using Illumina MiSeq. Results: The results revealed that both pregnancy and HPV infection can increase vaginal bacterial microbial richness and diversity, with the bacterial composition being most influenced by pregnancy. Lactobacillus was the most dominant genus among all samples. NPN samples were dominated by CST (community state type) III, mainly composed of Lactobacillus iners. Both pregnancy and hrHPV infection were accompanied by an increased proportion of CST I (dominated by Lactobacillus crispatus), as opposed to CST III. Bifidobacterium, Bacillus, Megasphaera, Sneathia, Prevotella, Gardnerella, Fastidiosipila and Dialister were found to be biomarkers for hrHPV-infected women, though different genera (Bifidobacterium, Megasphaera, Bacillus, Acidovorax, Oceanobacillus and Lactococcus) were associated with hrHPV-infected pregnant women. Conclusions: This work uncovered a probable synergistic effect of hrHPV infection and pregnancy on the vaginal microbial composition. HPV infection in pregnant women was associated with a more complex and diverse microbial environment.

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A case of pyometrocolpos with Bifidobacterium species

Cited by 8 publications

References 16 publications

Endometrial microbiota composition is associated with reproductive outcome in infertile patients

Endometrial microbiota composition is associated with reproductive outcome in infertile patients

Endometrial microbiota composition is associated with reproductive outcome in infertile patients

Association between the vaginal microbiome and high-risk human papillomavirus infection in pregnant Chinese women

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