A Case of Recurred Hepatocellular Carcinoma Refractory to Doxorubicin After Liver Transplantation Showing Response to Herbal Medicine Product, Rhus verniciflua Stokes Extract

Kim, Hye Ryun; Kim, Kyung Seok; Jung, Hae-Ok; Choi, Wonjun; Eo, Wan Kyu; Cheon, Seon Hee

doi:10.1177/1534735409359772

Cited by 15 publications

(7 citation statements)

References 22 publications

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“…Our patient had terminal HCC, for which he received palliative care with GCJ and CIK cell-based immunotherapy. The efficacy of these two therapies for HCC has been reported in previous studies (Takayama et al, 2000;Wang et al, 2002;Son et al, 2005;Weng et al, 2008;Hui et al, 2009;Kim et al, 2010;Lee et al, 2015;Chae et al, 2018). RVS extract is an anticancer substance that promotes cancer cell apoptosis, suppresses cancer cell growth, and inhibits angiogenesis (Choi et al, 2012).…”

Section: Adverse Event and Safetymentioning

confidence: 84%

Feasibility of combination of Gun-Chil-Jung and cytokine-induced killer cells-based immunotherapy for terminal hepatocellular carcinoma patient: a case report

Park,

Bae,

Lee

et al. 2023

Front. Pharmacol.

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Introduction: Terminal-stage hepatocellular carcinoma (HCC) is inoperable and currently has no form of adjuvant therapy. This study examined the anticancer herbal extract Gun-Chil-Jung (GCJ) combined with cytokine-induced killer (CIK)-cell-based immunotherapy as a palliative therapy for terminal HCC. We report the case of an HCC patient with extended overall survival and improved symptoms and tumor marker levels following combination therapy with GCJ and CIK cell-based immunotherapy.Baseline Characteristics: From March to July 2020, a 57-year-old man who had been diagnosed with HCC underwent combination treatment with GCJ and CIK cell-based immunotherapy. By August 2021, he was prescribed GCJ. After treatment, the patient’s condition was evaluated with respect to overall survival, tumor markers, symptoms, abdominal computed tomography findings, chest x-ray results, and Eastern Cooperative Oncology Group (ECOG) grade.Results: The patient’s overall survival, tumor marker levels, ECOG grade, and symptoms, including ascites, lower limb edema, jaundice, pleural effusion, and fatigue, were largely alleviated.Conclusion: We expect that this combination therapy may be an option for palliative therapy of terminal HCC.

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Section: Adverse Event and Safetymentioning

confidence: 84%

Feasibility of combination of Gun-Chil-Jung and cytokine-induced killer cells-based immunotherapy for terminal hepatocellular carcinoma patient: a case report

Park,

Bae,

Lee

et al. 2023

Front. Pharmacol.

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“…In addition, the anticancer effects of RVS were reported in an in vitro study of various cancer cell lines, including Lewis lung carcinoma, non-small cell lung cancer, human lymphoma, osteosarcoma, and breast cancer cells [ 20 27 28 29 30 ]. Several case studies and clinical studies have reported positive effects of RVS, including tumor size reduction and prolonged survival time, in advanced and metastatic cancer patients [ 16 31 32 33 34 35 ].…”

Section: Discussionmentioning

confidence: 99%

Rhus verniciflua Stokes extract suppresses migration and invasion in human gastric adenocarcinoma AGS cells

Lee

Jung

Kim³

et al. 2020

Nutr Res Pract

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BACKGROUND/OBJECTIVES: Many studies have suggested that Rhus verniciflua Stokes (RVS) and its extract are anticancer agents. However, RVS had limited use because it contains urushiol, an allergenic toxin. By improving an existing allergen-removal extraction method, we developed a new allergen-free Rhus verniciflua Stokes extract (RVSE) with higher flavonoid content. In this study, we examined whether RVSE inhibits the ability of AGS gastric cancer cells to migrate and invade. MATERIALS/METHODS: The flavonoids content of RVSE was analyzed by HPLC. The effects of RVSE on migration and invasion in AGS cells were analyzed by each assay kit. Matrix metalloproteinase (MMP)-9, plasminogen activator inhibitor-1 (PAI-1) and urokinase-type plasminogen activator (uPA) protein expression was analyzed by protein antibody array. The Phosphorylation of signal transducer and activator of transcription (STAT) 3 were assayed by Western blot analysis. RESULTS: RVSE treatment with 0-100 μg/mL dose-dependently reduced the ability of AGS cells to migrate and invade. Notably, treatment with RVSE strongly inhibited the expression of MMP-9 and uPA and the phosphorylation of STAT3. In contrast, RVSE treatment dramatically increased the expression of PAI-1. These results indicate that the inhibition of MMP-9 and uPA expression and STAT3 phosphorylation and the stimulation of PAI-1 expression contributed to the decreased migration and invasion of AGS cells treated with RVSE. CONCLUSIONS: These results suggest that RVSE may be used as a natural herbal agent to reduce gastric cancer metastasis.

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“…RVS is used as a traditional herbal therapy for the treatment of abdominal masses. 14 Its efficacy and safety has been reported for various cancer types, including colon, 15 gastric, 16 hepatobiliary, [17][18][19] renal, 20 pancreatic, 21 and pulmonary. [22][23][24] In these, it has shown improved OS and PFS compared with standard treatments, without significant adverse events.…”

Section: Discussionmentioning

confidence: 99%

Prolonged Progression-Free Survival in a Patient With Malignant Pleural Mesothelioma Following Korean Herbal Medicine Treatment Alone: A Case Report

et al. 2020

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Korean herbal medicine treatment (KHMT) involves treating with a combination of natural products, which have been used for thousands of years. Recently, it has been reported to be effective and safe in cancer patients. This case report demonstrates the efficacy of KHMT in a 49-year-old man with malignant pleural mesothelioma (MPM), a rare and highly aggressive cancer. The patient showed recurrent pleural effusion and was diagnosed with epithelioid MPM at cT3NxM0 stage III in December 2017. The multidisciplinary care team recommended multimodal treatment based on an extrapleural pneumonectomy, but he refused this because the treatment was aggressive and the effectiveness was unclear. He decided to undergo pemetrexed plus cisplatin chemotherapy if his condition worsened. He visited the Korean Medicine Cancer Center for alternative treatment options. A KHMT regimen, consisting of twice-daily Gunchil-dan and thrice-daily Bangam-tang, was initiated in December 2017. Since commencement of KHMT, computed tomography and X-ray imaging scans have shown no significant interval changes and progression. At 21 months into treatment (September 2019), no significant adverse events have occurred. Given that the median overall survival of patients with MPM is approximately 1 year, the ongoing progression-free survival of this patient for 21 months is relatively long. This case, therefore, suggests that KHMT is a potential treatment option for MPM patients.

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A Case of Recurred Hepatocellular Carcinoma Refractory to Doxorubicin After Liver Transplantation Showing Response to Herbal Medicine Product, Rhus verniciflua Stokes Extract

Cited by 15 publications

References 22 publications

Feasibility of combination of Gun-Chil-Jung and cytokine-induced killer cells-based immunotherapy for terminal hepatocellular carcinoma patient: a case report

Feasibility of combination of Gun-Chil-Jung and cytokine-induced killer cells-based immunotherapy for terminal hepatocellular carcinoma patient: a case report

Rhus verniciflua Stokes extract suppresses migration and invasion in human gastric adenocarcinoma AGS cells

Prolonged Progression-Free Survival in a Patient With Malignant Pleural Mesothelioma Following Korean Herbal Medicine Treatment Alone: A Case Report

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