A Case of Renin-Producing Adrenocortical Cancer.

Yamanaka, Kayo; Iitaka, Makoto; Inaba, Masaaki; Morita, Toshisuke; Sasano, Hironobu; Katayama, Shigehiro

doi:10.1507/endocrj.47.119

Cited by 12 publications

(12 citation statements)

References 12 publications

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“…Compression of the left renal artery by the tumor visualized by CT-scan and hypercortisolism could have favored renin hypersecretion by juxtaglomerular apparatus (Sacerdote et al 2005, Magiakou et al 2006. It was also conceivable that carcinoma may have synthesized and secreted substantial amounts of renin, as formerly reported (Iimura et al 1986, Racz et al 1992, Yamanaka et al 2000. In agreement with this latter hypothesis, we were able to detect the occurrence of mRNAs encoding renin and the renin protein in the tumor tissue by use of in situ hybridization and immunohistochemistry, respectively.…”

Section: E Louiset Et Al: 5-ht 7 Receptors In Adrenocortical Carcinomasupporting

confidence: 81%

“…Several observations suggest that the local renin-angiotensin system may be involved in adrenocortical carcinogenesis: 1) angiotensin II (Ang II) has been shown to stimulate in vitro the mitogenic activity of bovine adrenocortical cells (Gill et al 1977); 2) renin angiotensin systems are now considered as important actors of carcinogenesis in many tissues (Yoshiji et al 2004); 3) expression of renin, angiotensinogen, angiotensin-converting enzyme, and their messengers has been described in adrenocortical neoplasms including carcinomas (Racz et al 1992). In addition, two cases of adrenocortical tumors associated with elevated plasma renin concentrations have also been reported, indicating that, after its local synthesis, renin can be released in the plasma by tumor cells (Iimura et al 1986, Yamanaka et al 2000.…”

Section: Introductionmentioning

confidence: 99%

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Ectopic expression of serotonin7 receptors in an adrenocortical carcinoma co-secreting renin and cortisol

Louiset¹,

Isvi²,

Gasc³

et al. 2008

Endocrine Related Cancer

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Abnormal expression of membrane receptors has been previously described in benign adrenocortical neoplasms causing Cushing's syndrome. In particular, we have observed that, in some adreno corticotropic hormone (ACTH)-independent macronodular adrenal hyperplasia tissues, cortisol secretion is controlled by ectopic serotonin 7 (5-HT 7 ) receptors. The objective of the present study was to investigate in vitro the effect of serotonin (5-hydroxy tryptamine; 5-HT) on cortisol and renin production by a left adrenocortical carcinoma removed from a 48-year-old female patient with severe Cushing's syndrome and elevated plasma renin levels. Tumor explants were obtained at surgery and processed for immunohistochemistry, in situ hybridization and cell culture studies. 5-HT-like immunoreactivity was observed in mast cells and steroidogenic cells disseminated in the tissue. 5-HT stimulated cortisol release by cultured cells. The stimulatory effect of 5-HT on cortisol secretion was suppressed by the 5-HT 7 receptor antagonist SB269970. In addition, immunohistochemistry showed the occurrence of 5-HT 7 receptor-like immunoreactivity in carcinoma cells. mRNAs encoding renin as well as renin-like immunoreactivity were detected in endothelial and tumor cells. Cell incubation studies revealed that the adrenocortical tissue also released renin. Renin production was inhibited by 5-HT but was not influenced by ACTH and angiotensin II (Ang II). In conclusion, the present report provides the first demonstration of ectopic serotonin receptors, i.e. 5-HT 7 receptors, in an adrenocortical carcinoma. Our results also indicate that 5-HT can influence the secretory activity of malignant adrenocortical tumors in an autocrine/paracrine manner. The effects of 5-HT on adrenocortical tumor cells included a paradoxical inhibitory action on renin production and a stimulatory action on cortisol secretion involving 5-HT 7 receptors.

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Section: E Louiset Et Al: 5-ht 7 Receptors In Adrenocortical Carcinomasupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Ectopic expression of serotonin7 receptors in an adrenocortical carcinoma co-secreting renin and cortisol

Louiset¹,

Isvi²,

Gasc³

et al. 2008

Endocrine Related Cancer

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“…However, it is unclear why this symptom is less prevalent in the modern medical era. Other rare paraneoplastic syndromes are hyperreninemic hyperaldosteronism, erythropoietin-associated polycythemia, and leukocytosis (caused by chemokine release from the tumor) (82)(83)(84).…”

Section: Patient Presentation/clinical Characteristicsmentioning

confidence: 99%

Adrenocortical Carcinoma

et al. 2013

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Adrenocortical carcinoma (ACC) is a rare endocrine malignancy, often with an unfavorable prognosis. Here we summarize the knowledge about diagnosis, epidemiology, pathophysiology, and therapy of ACC. Over recent years, multidisciplinary clinics have formed and the first international treatment trials have been conducted. This review focuses on evidence gained from recent basic science and clinical research and provides perspectives from the experience of a large multidisciplinary clinic dedicated to the care of patients with ACC.

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“…An extrarenal renin‐producing tumor is extremely rare 6 . Non‐renal renin‐producing tumors include carcinoma of the lung, pancreas, urinary bladder and ovary 7 . To the best of our knowledge, there have been only two cases of renin‐producing adrenal tumor reported before.…”

Section: Discussionmentioning

confidence: 99%

“…More than half (59.3–60% 3,4 ) of adrenocortical carcinomas secrete hormones, most commonly cortisol, followed by androgens, estrogen, and aldosterone 5 . Nevertheless, renin‐producing carcinoma of the adrenal cortex is extremely rare, with only two cases described to date 6,7 …”

Section: Introductionmentioning

confidence: 99%

Newly developed hypertension as an early marker of recurrence of adrenocortical carcinoma with high renin expression

2008

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Adrenocortical carcinoma can recur frequently after successful surgery but no adequate markers can detect this recurrence. Here, we present a recurrence of adrenocortical carcinoma with a high renin expression, after successful surgery, where hypertension has developed again. Tumor recurrence was observed via 18 F-fluorodeoxyglucose positron emission tomography and coregistered computed tomography. Based on our findings, follow-up blood pressure assessment may effectively predict the recurrence of adrenocortical carcinoma.

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A Case of Renin-Producing Adrenocortical Cancer.

Cited by 12 publications

References 12 publications

Ectopic expression of serotonin7 receptors in an adrenocortical carcinoma co-secreting renin and cortisol

Ectopic expression of serotonin7 receptors in an adrenocortical carcinoma co-secreting renin and cortisol

Adrenocortical Carcinoma

Newly developed hypertension as an early marker of recurrence of adrenocortical carcinoma with high renin expression

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