A Case of Retroperitoneal Castleman’s Disease and an Update on the Latest Evidence

Abstract

Castleman's disease is a benign lymphoproliferative condition with three distinct histological subtypes. Clinically it presents in either a unicentric or multicentric manner and can affect various anatomic regions, the mediastinum being the most frequent location. We herein present a rare case of unifocal retroperitoneal mass proved to be hyaline vascular Castleman's disease. We perform a review of the current literature pertaining to such lesions, focusing on the management of the various clinical and histological variants of the disease. Surgical excision is the treatment of choice for unifocal Castleman's disease.

Unicentric Castleman’s Disease Masquerading as Retroperitoneal Sarcoma—Two Paraneoplastic Presentations of a Rare Disease

“…On computed tomography, a CD usually shows a solid homogenous hypervascular mass when the tumor is smaller, whereas larger tumors because of necrosis or fibrosis have more heterogeneous enhancement with a central hypodense area [8]. This pattern was similar to our second case, where the mass lesion mirrored the classic description.…”

Localized Castleman’s Disease in Retroperitoneum Mimicking Broad Ligament Leiomyoma – a Diagnostic Challenge

“…Retroperitoneal tumors can cause a diagnostic dilemma and present several therapeutic challenges because of their rarity, relative late presentation, and anatomical location, often in close relationship with several vital structures in the retroperitoneal space. 1 /RFDOL]HG &DVWOHPDQ 'LVHDVH &' DV D GLIIHUHQWLDO diagnosis of retroperitoneal tumours is a rare occurrence, with incidence of only 4% cases occurring in diverse locations like retroperitoneum. 2 On gross, the specimen consisted of body of uterus and cervix along with a large round well circumscribed mass measuring 17 cm in its greatest dimension.…”