A case of salivary gland-type mixed tumor of the lung differentiating toward type II alveolar epithelial cells in glandular components with a literature review

Matsumoto, Manabu; Shinmoto, Hiroshi; Furihata, Mutsuo; Nonami, Yoshiki; Ohmori, Yoshinobu; Ohtsuki, Yuji

doi:10.1007/s00428-002-0672-3

Cited by 8 publications

(11 citation statements)

References 8 publications

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“…This tumor, occurring in a 74-year-old man, contained glandular areas with type II pneumocytic differentiation (surfactant protein positive) and a solid myoepithelial cell component. 9 This tumor also had chondromyxoid stroma and well-developed areas of cartilage formation, similar to conventional mixed tumor. Cartilage was lacking in the 5 cases of PAM described here.…”

Section: Discussionmentioning

confidence: 92%

Pneumocytic Adenomyoepithelioma: A Distinctive Lung Tumor With Epithelial, Myoepithelial, and Pneumocytic Differentiation

Chang

Husain

Colby

et al. 2007

American Journal of Surgical Pathology

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Pulmonary tumors with epithelial and myoepithelial differentiation are rare, thought to be of bronchial minor salivary gland origin and classified similarly to salivary gland neoplasms. We report a series of a distinctive subtype of pulmonary glandular tumors showing epithelial and myoepithelial differentiation with further pneumocytic specialization. All patients were women, aged 52 to 63 years and presented with single or multiple pulmonary nodules. The tumors were grossly circumscribed, 0.8 to 2.6 cm in greatest dimension, and histologically showed glandular and spindle cell differentiation. Some glands were filled with colloidlike secretion and had an inner, cuboidal epithelial cell layer (pankeratin, epithelial membrane antigen, and thyroid transcription factor-1 positive), surrounded by an outer layer of myoepithelial cells merging with foci of spindled myoepithelial cells (high molecular weight keratin, S100, smooth muscle actin, calponin, caldesmon, and p63 positive). There were also some glands lined by a single layer of plump cells that were positive for surfactant protein-A in addition to the other epithelial cell markers. Electron microscopy confirmed pneumocytic features in these cells and the myoepithelial nature of the spindled cells. The surgery in all cases was wedge resection of the masses. The biologic behavior to date has been benign. This is the first reported series of a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation that differs histologically from all previously recognized pulmonary salivary gland-type and pneumocytic tumors. It is a unique benign appearing neoplasm for which the designation pneumocytic adenomyoepithelioma is suggested.

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Section: Discussionmentioning

confidence: 92%

Pneumocytic Adenomyoepithelioma: A Distinctive Lung Tumor With Epithelial, Myoepithelial, and Pneumocytic Differentiation

Chang

Husain

Colby

et al. 2007

American Journal of Surgical Pathology

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“…In a literature review of 24 cases of salivary gland-type mixed tumor of the lung, Matsumoto et al7 suggested that peripherally developed tumors might be derived from primitive stem cells with the ability to differentiate toward ductal structures, myoepithelium, and chondroid and myxoid matrix components. However, our case is morphologically different from pleomorphic adenoma, and immunohistochemical staining of myoepithelial cells showed positivity for normal myoepithelial cells within glands and negative for the stromal cells, while pleomorphic adenoma shows positivity for the stromal cells.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Pulmonary Mucous Gland Adenoma with Fibromyxoid Stroma and Cartilage Islands in 68-Year-Old Woman

et al. 2014

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“…But, it was documented in other salivary gland tumors of the lung, such as salivary gland-type mixed tumors and epithelial-myoepithelial tumors [11-13]. The TTF-1 positive tumor cells were also located at the inner layers of glandular components in these tumors, and were considered as alveolar epithelial differentiation [11-13]. It is indicated that the alveolar epithelial differentiation of glandular epithelia might be a special character in the salivary gland tumors of the lung and should be noted.…”

Section: Discussionmentioning

confidence: 99%

The alveolar epithelial differentiation of glandular inner lining cells in a mucoepidermoid carcinoma of the lung: a case report

Lin

et al. 2012

Diagn Pathol

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Mucoepidermoid carcinoma is a common malignant epithelial tumor of salivary glands, but relatively rare in lung. The histological features of mucoepidermoid carcinoma of the lung are similar to its counterpart arising from the salivary glands. Here, we reported a special tumor that occurred in the medial segment of the right lower lobe in a 22-year-old man. This tumor exhibited typical features of mucoepidermoid carcinoma with 3 cell types: squamoid cells, mucin-secreting cells and cells of intermediate type. These 3 types of cells organized into cysts, nests, glands and solid patterns. Specially, the inner lining cells of some glandular structures were uniform cuboidal and hobnail-like, similar to the alveolar epithelial cells. Immunohistochemistry staining revealed that the inner lining cells of glandular structures were positive for thyroid transcription factor-1 and surfactant protein-B, used as markers of alveolar epithelial cells, and were negative for p63. These findings for the first time demonstrated a rare alveolar epithelial differentiation of glandular inner lining cells in a mucoepidermoid carcinoma of the lung.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7095988968057804

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A case of salivary gland-type mixed tumor of the lung differentiating toward type II alveolar epithelial cells in glandular components with a literature review

Cited by 8 publications

References 8 publications

Pneumocytic Adenomyoepithelioma: A Distinctive Lung Tumor With Epithelial, Myoepithelial, and Pneumocytic Differentiation

Pneumocytic Adenomyoepithelioma: A Distinctive Lung Tumor With Epithelial, Myoepithelial, and Pneumocytic Differentiation

An Unusual Case of Pulmonary Mucous Gland Adenoma with Fibromyxoid Stroma and Cartilage Islands in 68-Year-Old Woman

The alveolar epithelial differentiation of glandular inner lining cells in a mucoepidermoid carcinoma of the lung: a case report

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