A Case of Seborrheic Keratosis and Family Survey

Xie, Fei; Wang, R; Chen, Y; Jia, Yulin; Jia, X; M, Chen; Yang, L; Lan, X

doi:10.7727/wimj.2014.221

Cited by 2 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A positive family history is often seen in patients with a higher number of lesions 8 . The pattern of inheritance is reported to be autosomal dominant, with incomplete penetrance 9 …”

Section: Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Update of pathophysiology and treatment options of seborrheic keratosis

Gorai¹,

Ahmad

Raza

et al. 2022

Dermatologic Therapy

View full text Add to dashboard Cite

Seborrheic keratosis (SK) is a common, benign tumor that can occur on everybody site and can be conservatively managed. Cosmetic concerns, especially when a lesion involves the facial area, are the most common reason for excision. SK shows male gender preponderance and increasing age is an independent association with the condition. Even though more prevalent in the elderly, it has also been reported in younger age groups like adolescents and young adults. Precise pathogenesis is still obscure, but ultra-violet exposure represents a predisposing factor to SK by altering the biochemical concentration and expression of factors like Glutamine deaminases, endothelin, and stem cell factor. Moreover, the accumulation of amyloid-associated protein has also been postulated. Involvement of genitalia has been associated with human papillomavirus infection. Recently, Merkel cell polyomavirus nucleic acid was also detected in SK. Several oncogenic mutations involving FGFR-3 and FOXN1 have been identified. SKs are usually classified clinically and histologically. Dermatoscopy is a noninvasive alternative diagnostic technique widely used in differentiating SK from other benign and malignant tumors. In terms of treatment, topical agents, shave dissection, cryosurgery, electrodesiccation, laser application and curettage under local anesthesia are safe methods for eradication of SKs, mostly for cosmetic purposes. Though generally safe, the latter techniques may occasionally cause postprocedure depigmentation, scarring, and recurrence. Nanosecond-pulsed electric field technology is a promising new technique with fewer side-effects.

show abstract

“…A positive family history is often seen in patients with a higher number of lesions 8 . The pattern of inheritance is reported to be autosomal dominant, with incomplete penetrance 9 …”

Section: Epidemiologymentioning

confidence: 99%

“…8 The pattern of inheritance is reported to be autosomal dominant, with incomplete penetrance. 9 3 | PATHOGENESIS…”

mentioning

confidence: 99%

Update of pathophysiology and treatment options of seborrheic keratosis

Gorai¹,

Ahmad

Raza

et al. 2022

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…DPN is found more often in African American, East Asian, and South Asian populations (Fitzpatrick IV-VI) with a consistently reported predominance in women and is thought to be underrecognized [33][34][35][36]. There is a high likelihood of family history, especially in individuals with large numbers of lesions [37][38][39][40][41]. Autosomal dominant inheritance with incomplete penetrance has been proposed [11,40,42].…”

Section: Epidemiologymentioning

confidence: 99%

Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses

Sun

Halpern

2021

Dermatology

View full text Add to dashboard Cite

Seborrheic keratoses (SKs) are ubiquitous, generally benign skin tumors that exhibit high clinical variability. While age is a known risk factor, the precise roles of UV exposure and immune abnormalities are currently unclear. The underlying mechanisms of this benign disorder are paradoxically driven by oncogenic mutations and may have profound implications for our understanding of the malignant state. Advances in molecular pathogenesis suggest that inhibition of Akt and APP, as well as existing treatments for skin cancer, may have therapeutic potential in SK. Dermoscopic criteria have also become increasingly important to the accurate detection of SK, and other noninvasive diagnostic methods, such as reflectance confocal microscopy and optical coherence tomography, are rapidly developing. Given their ability to mimic malignant tumors, SK cases are often used to train artificial intelligence-based algorithms in the computerized detection of skin disease. These technologies are becoming increasingly accurate and have the potential to significantly augment clinical practice. Current treatment options for SK cause discomfort and can lead to adverse post-treatment effects, especially in skin of color. In light of the discontinuation of ESKATA in late 2019, promising alternatives, such as nitric-zinc and trichloroacetic acid topicals, should be further developed. There is also a need for larger, head-to-head trials of emerging laser therapies to ensure that future treatment standards address diverse patient needs.

show abstract

A Case of Seborrheic Keratosis and Family Survey

Cited by 2 publications

References 3 publications

Update of pathophysiology and treatment options of seborrheic keratosis

Update of pathophysiology and treatment options of seborrheic keratosis

Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses

Contact Info

Product

Resources

About