A Case of Severe CMV-colitis in an HIV Positive Patient Despite Moderate Immunodeficiency

Wolf, Timo; Bickel, Markus; Faust, Dominik; Fellbaum, Christian; Brodt, Hans-Reinhard

doi:10.1080/00365540310017096

Cited by 9 publications

(8 citation statements)

References 8 publications

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“…Cytomegalovirus (CMV) colitis is a common cause of lifethreatening opportunistic viral infection, especially in immunocompromised patients such as transplant recipients and HIV-infected patients. [1][2][3][4] Cytomegalovirus infections are generally asymptomatic in healthy adults, but CMV infection in immunocompromised host has very serious and fatal clinical outcomes. 5 Symptomatic CMV infection in immunocompetent patients has traditionally been considered to have a benign and self-limited course.…”

Section: Introductionmentioning

confidence: 99%

A case of cytomegalovirus colitis in an immunocompetent hemodialysis patient

Kim¹,

Kim

Kim³

et al. 2011

Hemodialysis International

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Symptomatic cytomegalovirus (CMV) infection in immunocompetent patients has traditionally been considered to have a benign and self-limited course. Moreover, current concept is that CMV infection in immunocompetent patients does not require treatment. However, recent studies reveal that CMV infection in immunocompetent patient with clinical manifestation is not a rare condition as thought previously. Here, we report a case of CMV colitis, which occurred in an immunocompetent hemodialysis patient who neither had HIV infection nor had medication that could cause immunosuppression. Our case revealed that the conservative treatment was not enough, and the administration of ganciclovir was essential for improving the disease course.

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Section: Introductionmentioning

confidence: 99%

A case of cytomegalovirus colitis in an immunocompetent hemodialysis patient

Kim¹,

Kim

Kim³

et al. 2011

Hemodialysis International

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“…Several studies have shown that immune reconstitution of specific T cell responses to a number of pathogens, including CMV, can occur following a HAART regimen [16, 17, 18, 19]. In a study by Deayton et al [16] on HIV patients, CMV DNA levels in the blood rapidly declined after the initiation of HAART.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus Infection of the Colon Presenting as a Mass-Like Lesion

Tan

Vardaros²,

Prasad³

et al. 2012

Case Rep Gastroenterol

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Cytomegalovirus (CMV) is responsible for the most common opportunistic infections in patients with acquired immunodeficiency syndrome (AIDS). The colon is a common site for these infections in patients positive for human immunodeficiency virus. CMV rarely presents as an intraluminal inflammatory mass in the colon. Here we report the case of a CMV infection presenting as a mass-like lesion in an AIDS patient. The clinical diagnosis of CMV infection is largely based on the characteristic endoscopic appearance. Endoscopic procedures are encouraged early in the course of CMV infection in immunocompromised patients. CMV pseudotumors along with malignancy should be part of the endoscopic evaluation in patients with AIDS.

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“…There have been few cases of CMV gastrointestinal disease reported in patients with CD4 counts greater than 50 cells/µL to 100 cells/µL (2,3). We describe a case of CMV colitis in an HIV-infected patient with a relatively preserved CD4 count.…”

Section: Cytomegalovirus Colitis In An Hiv-positive Woman With a Relamentioning

confidence: 96%

“…Two cases of HIV-infected patients with CMV colitis and relatively preserved CD4 counts in the setting of malnutrition and alcoholism have been described previously (2,3). Malnutrition has long been associated with anergy and impaired T cell function, thereby potentially predisposing patients to reactivation of CMV (4).…”

Section: Cytomegalovirus Colitis In An Hiv-positive Woman With a Relamentioning

confidence: 99%