FDG-PET/CT is a highly sensitive tool for detecting new or recurrent cancer lesions, however, it has been pointed out that it can also yield false-positive results in some cases. A 79-year-old man underwent right hemicolectomy for ascending colon cancer. His serum CEA level increased 20 months after the initial operation. FDG-PET/CT showed abnormal accumulation at the anastomosis and in the right lower-quadrant abdominal wall. Colonoscopy did not reveal any changes suggestive of anastomotic recurrence. There were tumors in the abdominal wall and a biopsy was performed, which yielded a negative result for cancer. Nevertheless, since the possibility of cancer recurrence could not be ruled out, we decided to administer chemotherapy. Since colonoscopy revealed anastomotic recurrence 24 months later, colectomy and tumorectomy were performed. Histologically, anastomotic recurrence was confirmed, and the tumors were finally diagnosed as foreign body granulomas caused by the suture thread.