A Case of Topical Ofloxacin-Induced Otomycosis and Literature Review

Alshahni, Mohamed Mahdi; Alshahni, Rima Zakzuk; Fujisaki, Ryuichi; Tamura, Takashi; Shimizu, Yusei; Yamanishi, Chiaki; Makimura, Koichi

doi:10.1007/s11046-021-00581-x

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…Therefore, the use of Telipidal ear drops is necessary for adjuvant treatment, which can produce a good secretion of pathogenic bacteria in children. Only by suppressing the pathogenic bacteria in children can we truly and effectively remove the infection lesions, which is an important step in reducing the disease recurrence rate and the incidence of adverse reactions in children [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Endoscopic Tympanic Membrane Catheterization Plus Ofloxacin Ear Drops in the Treatment of Secretory Otitis Media in Infants and Toddlers

Zhao

Chen

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the efficacy and safety of endoscopic tympanic membrane catheterization and ofloxacin ear drops in the treatment of secretory otitis media in infants and toddlers. Methods. A total of 80 children suffering from secretory otitis media who underwent treatment in our hospital from July 2018 to April 2020 were divided into the control group (n = 40) and experimental group (n = 40) by randomization. The control group was treated with endoscopic tympanic membrane catheterization alone, while the experimental group was treated with ofloxacin ear drops based on the same treatment as the control group. The treatment effect, air conduction hearing level, clearance rate of pathogenic bacteria secreted by the ear canal, recurrence rate, and adverse reactions were compared between the two groups. Results. The treatment in the experimental group led to a significantly better outcome than that in the control group ( P < 0.05 ). After treatment, a substantially improved air conduction hearing level in the experimental group was observed ( P < 0.001 ). A chi-square test showed a significantly higher clearance rate of pathogenic bacteria secreted from the ear canal of the children in the experimental group compared to that of the control group ( P < 0.05 ). The treatment in the experimental group resulted in a lower recurrence rate and adverse reaction rate as compared to the control group ( P < 0.05 ). Conclusion. Concurrent endoscopic tympanic membrane catheterization and ofloxacin ear drops showed excellent efficacy in the treatment of secretory otitis media in infants and toddlers. The therapy offers promising solutions for the improvement of hearing level, increase of clearance rate of pathogenic bacteria secreted from the ear canal, and decrease of disease recurrence and adverse reactions during treatment.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Endoscopic Tympanic Membrane Catheterization Plus Ofloxacin Ear Drops in the Treatment of Secretory Otitis Media in Infants and Toddlers

Zhao

Chen

2022

Evidence-Based Complementary and Alternative Medicine

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“…Furthermore, in patients receiving long‐term ototopical antibiotic therapy, M . furfur may cause subsidiary infections, affecting the flora in the outer ear canal 20 . Particular attention should be given to M .…”

Section: Discussionmentioning

confidence: 99%

“…19 Furthermore, in patients receiving long-term ototopical antibiotic therapy, M. furfur may cause subsidiary infections, affecting the flora in the outer ear canal. 20 Particular attention should be given to M. furfur strains exhibiting strong resistance to antifungal drugs. 11 In this respect, FastFung agar would be helpful, as it demonstrated better results in M. furfur isolation than mDixon agar, although there was no difference in the variety of isolated species between the two media (Wilcoxon p = .28, McNemar p = .004; Table 3).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of FastFung agar in the isolation of Malassezia furfur from skin samples

Atsü

Ergin

Caf

et al. 2022

Mycoses

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Background Lipophilic basidiomycetous yeasts of the Malassezia genus can cause various skin diseases, such as seborrheic dermatitis, pityriasis versicolor, folliculitis and atopic dermatitis, and even life‐threatening fungemia in newborns and immunocompromised individuals. Routine mycological media used in clinical practice do not contain sufficient lipid ingredients required for the growth of Malassezia species. A recently developed medium, FastFung agar, is promising for culturing fastidious fungal species. Methods In this study, we compared FastFung agar and mDixon agar for culturing Malassezia species from nasolabial fold and retroauricular specimens of 83 healthy individuals and 187 and 57 patients with acne vulgaris and seborrheic dermatitis, respectively. Results Malassezia species were identified using conventional tests and matrix‐assisted laser desorption/ionisation mass spectrometry. In total, 96 of 654 samples (14.6%) contained Malassezia species. The total isolation rate was significantly higher in patients with seborrheic dermatitis (40.4%) than in healthy volunteers (21.7%; p < .05), and the rate of M. furfur isolation was significantly higher for patients with acne vulgaris (13.9%) and seborrheic dermatitis (24.6%) than for healthy individuals (1.5%; p < .05). FastFung agar was superior to mDixon agar in M. furfur isolation (p = .004) but showed similar performance in the case of non‐M. furfur species (p > .05). Among cultured Malassezia species, perfect agreement between mDixon agar and FastFung agar was found only for M. globosa (κ = 0.90). Conclusion Our results indicate that FastFung agar favours the growth of Malassezia species and should be useful in clinical mycology laboratories.

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“…Isolates that we were unable to appropriately identify were subjected to molecular analysis using DNA extracted by a Kaneka Easy DNA Extraction Kit (KANEKA Corp., Tokyo, Japan) in accordance with the manufacturer’s instructions. Using the two primer pairs 28SF1/635 and ITS1/ITS4 [ 1 , 3 ], we respectively amplified fragments of the 28S rDNA D1/D2 domain and the rDNA internal transcribed spacer (ITS) region, which were subsequently sequenced using an Applied Biosystems model 3130 sequencer. To identify the generated sequences, sequence similarity was assessed based on searches using the Basic Local Alignment Search Tool (BLAST) ( http://blast.ncbi.nlm.nih.gov/Blast.cgi ).…”

Section: Methodsmentioning

confidence: 99%

<i>Begerowomyces aurantius</i> sp. nov., a novel yeast isolated from koalas’ habitat in a Japanese zoological park

Guo

Alshahni

Satoh

et al. 2023

The Journal of Veterinary Medical Science

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Koalas are iconic mammals indigenous to Australia. These rare animals and their habitats are occasionally associated with pathogenic fungi, including species of Cryptococcus, and consequently, monitoring the mycobiota of areas inhabited by koalas is of considerable importance. In this report, we describe a novel basidiomycetous yeast isolated from a site in Kanazawa Zoo, Japan, associated with captive koalas. Swab samples were collected from koala breeding environments, from which we isolated a novel unencapsulated yeast characterized by ovoid to ellipsoidal cells (3.2-4.9 × 3.5-5 μm). These cells were observed to undergo polar budding and grow as parent bud pairs, with an optimal growth temperature of 28°C. Colonies grown on yeast extract peptone dextrose agar at 28°C have a characteristic coral pink color. On the basis of physiological, morphological, and molecular characters, the new species was placed in the genus Begerowomyces, and the name Begerowomyces aurantius JCM33898 T (LSEM1333 T = CBS16241 T ) is proposed.

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A Case of Topical Ofloxacin-Induced Otomycosis and Literature Review

Cited by 9 publications

References 26 publications

Efficacy and Safety of Endoscopic Tympanic Membrane Catheterization Plus Ofloxacin Ear Drops in the Treatment of Secretory Otitis Media in Infants and Toddlers

Efficacy and Safety of Endoscopic Tympanic Membrane Catheterization Plus Ofloxacin Ear Drops in the Treatment of Secretory Otitis Media in Infants and Toddlers

Effectiveness of FastFung agar in the isolation of Malassezia furfur from skin samples

<i>Begerowomyces aurantius</i> sp. nov., a novel yeast isolated from koalas’ habitat in a Japanese zoological park

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