A Case of Tuberculum Sellae Chordoid Meningioma Treated via Extended Endoscopic Endonasal Trans-sphenoidal Surgery

Yagi, Chihiro; Yamamuro, Shun; Ozawa, Yuichiro; Yoshimura, Sodai; Sumi, Koichiro; Yoshino, Atsuo

doi:10.2176/nmccrj.cr.2019-0083

Cited by 3 publications

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“…Current literature regarding CM and CCM consists of isolated case reports and a small number of institutional series. To the best of our knowledge, only 22 studies with 423 CM cases have been reported until now [4][5][6][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] while less than 20 studies reported the outcomes of CCM. Owing to the limited case numbers of CM and CCM, few studies have comprehensively investigated the clinical, pathological, and prognosis differences among these 3 histological subtypes of grade 2 meningiomas.…”

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confidence: 99%

Favorable Long-Term Outcomes of Chordoid Meningioma Compared With the Other WHO Grade 2 Meningioma Subtypes

et al. 2022

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BACKGROUND:WHO grade 2 meningiomas, including atypical, chordoid, and clear cell subtypes, form a heterogenous group of meningiomas with varying aggressiveness and clinical behavior.OBJECTIVE:To demonstrate the differences of clinical-histopathological characteristics and long-term outcomes among these 3 subtypes.METHODS:A total of 609 consecutive patients diagnosed with WHO grade 2 meningiomas (543 atypical meningiomas [AMs], 36 chordoid meningiomas [CMs], and 30 clear cell meningiomas [CCMs]) from 2010 to 2018 were enrolled in this study. We compared the clinical-histopathological characteristics and long-term outcomes in these 3 subtypes and assessed survival differences among the subtypes. Targeted panel sequencing of meningioma-relevant genes was performed in the cases of CM.RESULTS:The patients with CCM were significantly younger than those with AM (P < .001) and CM (P = .016). CMs were more likely to receive gross total resection than AMs and CCMs (P = .033). The Ki-67 index was lower (P < .001) while the progesterone receptors-positive rate was higher (P = .034) in CM than in AM and CCM. Importantly, survival analysis demonstrated that CM had better progression-free survival (P = .022) and overall survival (P = .0056) than non-CM tumors. However, the PFS of CM was still worse than WHO grade 1 meningiomas (P < .001). Alterations in NF2 (20.6%) and KMT2C (26.5%) were associated with poorer PFS in CM (P = .013 for NF2; P = .021 for KMT2C).CONCLUSION:Patients with CM had better long-term postoperative outcomes than the other WHO grade 2 subtypes. A lower Ki-67 index, higher PR status, higher extent of resection, and lower frequency of NF2 alteration might contribute to favorable clinical outcomes of CM.

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confidence: 99%

Favorable Long-Term Outcomes of Chordoid Meningioma Compared With the Other WHO Grade 2 Meningioma Subtypes

et al. 2022

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“…• Chordoid meningioma-tumour cells are arranged as cords, have eosinophilic cytoplasm and embedded in an abundant myxoid rich background [72] • Clear cell meningioma-spindled to polygonal cells having whorled and syncytial architecture, cells have bland nuclear chromatin and vacuolated cytoplasm [73] • Rhabdoid meningioma-rhabdoid cells having eccentrically placed nuclei, vesicular chromatin, prominent nucleoli, dense eosinophilic cytoplasm and distinct cell borders. Cytoplasmic hyaline inclusions, pseudo nuclear inclusions, stout processes and increased mitotic activity may be identified [74] • Papillary meningioma-papillary architecture seen on low power field [62] • Anaplastic meningioma-increased atypical mitotic figures [40].…”

Section: Squash Cytologymentioning

confidence: 99%

Molecular alterations, histopathology and squash cytology of Meningioma

Kumar Chowhan,

Agrawal

2024

Meningioma - The Essentials From Bench to Bedside

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Meningioma originates from the arachnoid cap cells of duramater. It is a slow growing tumour of Central Nervous System. It is seen more commonly in females at around 66 years of age. The most common genetic abnormality is monosomy of chromosome 22. Since the inception of World Health Organisation (WHO), meningioma was graded based on histo-morphological appearance. At present, they are categorised into 3 grades. This chapter describes the molecular alterations, histopathological grading, histopathological subtypes and squash cytology of meningioma.

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