A case report of a hybrid odontogenic tumour: Ameloblastoma and adenomatoid odontogenic tumour in calcifying cystic odontogenic tumour

Zhang, Weiping; Chen, Yu; Geng, Ning; Bao, Dongmei; Mi, Yang

doi:10.1016/j.ooe.2006.07.003

Cited by 24 publications

(24 citation statements)

References 18 publications

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“…Case reports by Shetty et al [12] and Handschel et al [13] described an AOT exhibiting a cyst, but were excluded as the reports lacked a description of the lining epithelium. Zhang et al [14] reported a case of hybrid odontogenic tumour of calcifying cystic odontogenic tumour, ameloblastoma and AOT. The welldocumented report described the cystic lining showing nests of ghost cells and the connective tissue capsule exhibiting AOT like areas.…”

Section: Discussionmentioning

confidence: 99%

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Adenomatoid odontogenic tumour: Tumour or a cyst, a histopathological support for the controversy

Gadewar¹,

Natarajan

2010

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

“…The cystic component of AOT has been variedly termed as dentigerous cyst [9,[16][17][18], calcifying odontogenic cyst [10,14,19] or unicystic ameloblastoma [20]. Table 1 summarizes the age, site, radiographic and histopathological presentation of the previous case reports of AOT showing a cystic lining histologically.…”

Section: Discussionmentioning

confidence: 99%

Adenomatoid odontogenic tumour: Tumour or a cyst, a histopathological support for the controversy

Gadewar¹,

Natarajan

2010

International Journal of Pediatric Otorhinolaryngology

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“…Unfortunately, no follow-up data is available for our cases. Many authors believe that hybrid odontogenic lesions are not a result of collision between two distinct entities but rather due to the pluripotentiality of the odontogenic epithelium with both lesions likely developing from a common source or ameloblastomatous change in an existing odontogenic cyst [10][11][12]. We feel this is likely of the ameloblastoma with COC; however, the ameloblastoma with OKC appears to be two distinct entities arising nearly in the same location.…”

Section: Discussionmentioning

confidence: 81%

“…We have compiled the reported cases, excluding ours, into a table which serves as an updated version similar to Lin et al's (Table 1) [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Information in the table includes location, sex, age, treatment, and any follow-up data.…”

Section: Discussionmentioning

confidence: 99%

Report of Two Cases of Combined Odontogenic Tumors: Ameloblastoma with Odontogenic Keratocyst and Ameloblastic Fibroma with Calcifying Odontogenic Cyst

Neuman

Montague

Cohen

et al. 2015

Head and Neck Pathol

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Combined odontogenic neoplasms have rarely been documented. Such tumors have also been described by other researchers as ''hybrid'' lesions. The histologic features are often identical to other individually wellestablished odontogenic neoplasms such as ameloblastoma, adenomatoid odontogenic tumor, ameloblastic fibroma (AF), and ameloblastic fibro-odontoma. Their clinical presentation is variable, ranging from cysts to neoplasms showing varying degrees of aggressive behavior. Most combined tumors contain features of one of the odontogenic tumors in combination with either a calcifying odontogenic cyst (COC) or a calcifying epithelial odontogenic tumor. We present two new cases of combined odontogenic tumors: an ameloblastoma with an odontogenic keratocyst and an AF with COC. Predicting clinical outcome is challenging when a combination tumor is encountered due to the paucity of such lesions. One must understand salient features of these entities and differentiate them from the more common conventional neoplasms to expand classification and provide prognostic criteria.

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“…These authors justified that these two tumours can develop in the same region because of the pluripotency of odontogenic epithelium. 11 Geng et al 4 defined that, when keratinisation occurs on the cell surface and the dominant areas are keratocystic, these lesions should be classified as keratocyst with ameloblastic areas.…”

Section: Discussionmentioning

confidence: 99%

Can ameloblastomas arise from odontogenic keratocysts?

et al. 2015

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| Background:The ameloblastoma is a locally aggressive odontogenic tumour that has high recurrence rates. It rarely presents a histological aspect similar to the odontogenic keratocyst, because of the presence of keratinised areas. This study aimed to report a case of ameloblastoma in the mandible, diagnosed and treated incorrectly as an odontogenic keratocyst because of unusual macroscopic characteristics and rare histological aspects that impaired a correct diagnosis. Case report: A 57-year-old female patient, presenting an asymptomatic lesion at the left mandibular angle, was treated by incisional biopsy and decompression. The histological sections showed an aspect suggesting odontogenic keratocyst. At the 3-year postoperative period, the patient returned with a new lesion on the left side of the mandible and was then subjected to curettage. The histological sections showed a pattern of ameloblastoma and, because of this, the patient remained with a 6-month follow-up. At the 4-year postoperative period after the second operation, the patient returned with a new recurrence. The biopsy showed an ameloblastoma and the patient was submitted to mandibular resection and reconstruction as treatment. After the final procedure, the recovery was uneventful and the patient is now undergoing a postoperative period of four years, without recurrences. Conclusion: This case highlights the importance of carrying out a proper biopsy and an adequate examination by a specialised professional, because of the possibility of atypical lesions occurring restricted to the head and neck region.DESCRIPTORS | Ameloblastoma; Jaw; Odontogenic Tumors. RESUMO | Os ameloblastomas podem surgir a partir dos queratocistos odontogênicos? • Introdução: O ameloblastoma é um tumor odontogênico localmente agressivo, com altas taxas de recorrência. Raramente o ameloblastoma apresenta aspecto histológico semelhante ao queratocisto odontogênico devido à presença de áreas queratinizadas. O objetivo deste estudo é relatar um caso de ameloblastoma na mandíbula, diagnosticado e tratado incorretamente como um queratocisto odontogênico devido a características macroscópicas incomuns e aspectos histológicos raros que prejudicaram um correto diagnóstico. Relato de caso: Paciente do sexo feminino, 57 anos, apresentando lesão assintomática no ângulo mandibular esquerdo tratado inicialmente com biópsia incisional e descompressão. Os achados histológicos mostraram um aspecto sugestivo de queratocisto odontogênico. No pós operatório de 3 anos, a paciente retornou com uma nova lesão no lado esquerdo da mandíbula e foi então submetida a curetagem. Desta vez, as seções histológicas mostraram um padrão de ameloblastoma e, devido a este fato, a paciente permaneceu com um seguimento de 6 meses. No pós operatório de 4 anos da segunda operação, a paciente retornou apresentando nova recidiva. A biópsia mostrou um ameloblastoma e a mesma foi submetida a ressecção mandibular e reconstrução como tratamento. Após o procedimento final, a recuperação foi sem intercorrênc...

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A case report of a hybrid odontogenic tumour: Ameloblastoma and adenomatoid odontogenic tumour in calcifying cystic odontogenic tumour

Cited by 24 publications

References 18 publications

Adenomatoid odontogenic tumour: Tumour or a cyst, a histopathological support for the controversy

Adenomatoid odontogenic tumour: Tumour or a cyst, a histopathological support for the controversy

Report of Two Cases of Combined Odontogenic Tumors: Ameloblastoma with Odontogenic Keratocyst and Ameloblastic Fibroma with Calcifying Odontogenic Cyst

Can ameloblastomas arise from odontogenic keratocysts?

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