A case report of cecal plasmablastic lymphoma in a HIV-negative patient

Mansoor, Muhammad; Alani, Fouad Sadik Saied; Aslam, Mohammed Babar; Kumar, Santhi N.; Sahasrabudhe, Neil; Khan, Durab

doi:10.1097/meg.0b013e32834eb8d0

Cited by 14 publications

(8 citation statements)

References 23 publications

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“…Over one-third of all PBL cases were first noted at extraoral locations, predominantly within the gastrointestinal tract. According to the relevant literature, the HIVnegative patients can have PBL in the stomach, small bowel, and colon 6,9,10,13,14 . PBL of the small intestine is extremely rare.…”

Section: Discussionmentioning

confidence: 99%

“…Plasmablastic lymphoma (PBL), a rare subtype of diffuse large B cell lymphoma, usually occurs in the patients with HIV infection and is primarily found in the oral cavity [1][2][3][4] . There are also reported cases of PBL in the immunocompetent individuals involving the cervical lymph nodes, stomach, lungs, cavity, small and large bowel, and liver [5][6][7][8][9][10][11][12][13][14][15] . This rare lymphoproliferative disorder is characterized by its plasmablastic morphology and immunohistochemical panel.…”

Section: Introductionmentioning

confidence: 99%

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Plasmablastic lymphoma as a rare cause of subocclusive events: Case report and review of the literature

Lukić

Dragašević²,

Zgradic³

et al. 2019

VOJNOSANIT PREGL

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Introduction. The most common causes of subocclusive disorders are the adhesion, Crohn's disease and small bowel neoplasms. Plasmablastic lymphoma (PBL) is an aggressive distinct subtype of diffuse large B-cell non-Hodgkin lymphoma initially reported in the oral cavity of the HIV infected individuals. Case report. We presented a male patient with PBL of the small intestine as a rare cause of intestinal subocclusion, without HIV infection and negative serology for hepatitis C, hepatitis B, and Epstein-Barr infection. A 73-year-old male was admitted to our Center due to the one-year history of abdominal pain, weigh loss, non-bloody diarrhea, night sweating and pruritus. The patient underwent the ileocolonoscopic examination with the accompanying biopsy specimens. The results, based on the histopathological and immunohistochemical pattern, confirmed a diagnosis of PBL. Following the chemo-therapy treatment, our patient underwent the resection of ileum. The postoperative histopathological report confirmed PBL as the final diagnosis. The patient was treated for the following 6 months with the chemotherapy according to the cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) protocol. Fatal outcome was due to acute myocardial infarct. Conclusion. PBL of the small intestine is a rare and unusual cause of subocclusive events. In our patient, an accurate histopathological verification of the detected changes in the ileum was of crucial importance for further treatment.Uvod. Najčešći uzroci subokluzivnih poremećaja u adheziji, Kronova bolest i neoplazme tankog creva. Plazmablastni limfom (PBL) je tip agresivnog difuznog krupnoćelijskog B nehočkinskog limfoma, koji je prvi put opisan u usnoj duplji kod HIV pozitivnih bolesnika. Prikaz bolesnika. U radu je prikazan bolesnik sa PBL tankog creva kao retkim uzrokom subokluzije, bez HIV infekcije i sa negativnom serologijom za hepatitis B, hepatitis C i infekciju Epštajn-Barovim virusom. Muškarac, star 73 godine, primljen je u naš Centar zbog jednogodišnje istorije bolova u trbuhu, gubitku telesne mase, dijareje (bez krvi), noćnog znojenja i svraba. Bolesniku je urađena kolonoskopija sa terminalnom ileoskopijom, pri kojoj je uzeta biopsija sluznice terminalnog ileuma. Rezultati patohistološkog i imunohistohemijskog ispitivanja su potvrdili dijagnozu PBL. Posle hemioterapije, bolesniku je urađena resekcija ileuma. Rezultat postoperativne patohistološke analize je potvrdio dijagnozu PBL. Bolesnik je lečen po protokolu CHOP (ciklofofamid, doksorubicin, vinkristin i prednizolon) tokom šest meseci. Fatalan ishod je nastupio zbog infarkta miokarda. Zaključak. Mada redak i neuobičajen, uzrok subokluzivnih tegoba može biti PBL ileuma. Kod našeg bolesnika krucijalni značaj za dalje lečenje je imala tačna patohistološka verifikacija promena aktiviranih u ileumu.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasmablastic lymphoma as a rare cause of subocclusive events: Case report and review of the literature

Lukić

Dragašević²,

Zgradic³

et al. 2019

VOJNOSANIT PREGL

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“…Plasmablastic lymphoma is a rare and aggressive B-cell lymphoma firstly described in 1997 by Delecluse et al in the oral cavity of the immunocompromised patients [8]. In recent years, cases have been reported in HIV-negative patients, observed in the nasopharynx, maxillary sinus, orbita, skin, lung, gastrointestinal tract, soft tissue, anus, vulva, and mediastinum [1][2][3][4][5][6][9][10][11]. HIV positivity is seen in 90% of the oral PBL cases, whereas the HIV positivity in non-oral PBL cases is less prevalent.…”

Section: Discussionmentioning

confidence: 99%

CD3 Positive Gastric Plasmablastic Lymphoma in A HIV Negative Patient: A Case Report

Kucukzeybek¹,

Çallı²,

Uyaroğlu³

et al. 2017

J Clin Exp Invest

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Plasmablastic lymphoma is a rare and aggressive lymphoma characterized by the diffuse proliferation of large neoplastic cells resembling immunoblasts with an immunophenotype of plasma cells. A 47-year-old male was referred to our hospital with gastrointestinal bleeding, and a mass, 10 cm in diameter, was detected. An endoscopic biopsy was performed subsequently. A histopathological examination of the biopsy material revealed ulcer, alterations associated with ulcer, and further presented a diffuse infiltration of atypical cells with abundant cytoplasm and pleomorphic nuclei, some with crush artifacts in lamina propria. Immunohistochemically, the tumor cells were negative for cytokeratin, CD2, CD20, and PAX5; but they were positive for CD3, MUM1, CD38, and CD138. Ki67 proliferation index was as high as 95%. The case was signed out as CD3-positive plasmablastic lymphoma with clinical, histopathological, and immunohistochemical findings. The plasmablastic lymphoma case with an aberrant CD3 expression will be presented here, which is rarely observed in stomach.

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“…Since then, many cases of HIV‐negative PBL have been reported in various oral and extra‐oral locations, with most occurring in the post‐transplant setting and in other immunocompromised states. Only a very small subset of cases of PBL has been reported in immunocompetent patients. To our knowledge, only four cases of PBL of the maxillary sinus have ever been reported in immunocompetent individuals.…”

Section: Introductionmentioning

confidence: 89%

Plasmablastic lymphoma of the maxillary sinus; a case report and review of the literature

2015

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Plasmablastic lymphoma (PBL) is a rare and aggressive variant of diffuse large B‐cell lymphoma (DLBCL). It is a recently described variant of non‐Hodgkin's lymphoma that occurs almost exclusively in human immunodeficiency virus (HIV) infection, in the post‐transplant setting and in other immunosuppressive states. Only a handful of cases have been reported in the literature affecting immunocompetent patients. We present a rare case of PBL arising in the maxillary sinus in an immunocompetent, HIV‐negative patient. The malignancy first presented in general dental practice as painless tooth mobility.

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A case report of cecal plasmablastic lymphoma in a HIV-negative patient

Cited by 14 publications

References 23 publications

Plasmablastic lymphoma as a rare cause of subocclusive events: Case report and review of the literature

Plasmablastic lymphoma as a rare cause of subocclusive events: Case report and review of the literature

CD3 Positive Gastric Plasmablastic Lymphoma in A HIV Negative Patient: A Case Report

Plasmablastic lymphoma of the maxillary sinus; a case report and review of the literature

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