A Case Report of Incidental Primary Leiomyosarcoma of the Fallopian Tube and a Review of the Recent Literature

Abstract

Primary leiomyosarcoma of the fallopian tube is a very rare neoplasm with descriptions limited to case reports. We present the case of a 46-yr-old woman with a history of renal transplantation in whom a primary leiomyosarcoma of the fallopian tube was identified incidentally following hysterectomy and bilateral salpingectomy undertaken for a uterine fibroid. The tumor demonstrated classic morphological and immunohistochemical features of a leiomyosarcoma. It appeared localized to the fallopian tube and was completely resected. Adjuvant therapy was not given but active surveillance initiated. After 14 mo of follow-up, there was no evidence of disease recurrence. We review cases from the past 20 yr with a focus on management and outcomes. Given the rarity of this disease, continued publication of case reports and the creation of a centralized case registry would be of benefit.

Giving birth after fertility‐sparing treatment for primary leiomyosarcoma of the fallopian tube

“…PLFT is rare and there are limited data on its treatment. Only 12 clearly identified cases have been reported over the past 30 years (Table 1), [1][2][3][4][5][6][7][8][9][10] and the precise cause and pathogenesis of PLFT are still incompletely understood. This gynecological neoplasm is characterized by local recurrence and distant metastases.…”

“…Primary leiomyosarcoma of the fallopian tube (PLFT) is a very rare and aggressive malignancy with poor documentation in the literature. [1][2][3][4][5][6][7][8][9][10] Despite the dire prognosis, there is no specific established treatment modality for PLFT. Most patients with PLFT undergo radical surgery 2,3,[6][7][8][9] or debulking surgery.…”

“…Primary leiomyosarcoma of the fallopian tube (PLFT) is a very rare and aggressive malignancy with poor documentation in the literature 1–10 . Despite the dire prognosis, there is no specific established treatment modality for PLFT.…”