A case report of Lhermitte–Duclos disease revealed by psychiatric disturbances

Abstract

BackgroundLhermitte–Duclos disease (LDD) is a rare cerebellar lesion characterized by a hamartomatous lesion in the posterior fossa. Mainly diagnosed by MRI, the clinical presentation is usually made of neurological symptoms.Case presentationWe present here a rare case of a woman who developed depressive symptoms that inaugurated the clinical presentation of LDD.ConclusionPsychiatric symptoms may occur in all brain lesions, delaying the diagnosis and causing therapeutic escalation. More attention should be given by practitioners to psychiatric aspects of LDD.

Cerebellar Dysplastic Gangliocytoma: Case Report

“…5 Generally, it has an indolent and chronic course, with the possibility of acute onset of symptoms. 3 It manifests with headache, visual disturbance, cerebellar dysfunction, ataxia, cranial nerve palsies, and obstructive hydrocephalus, 2,6,7 mainly in the 3 rd or 4 th decade of life. 6,7 Acute onset of neurological deficits, as in the case presented, is rarely reported.…”

“…8 The occurrence of associated hereditary syndromes, such as Cowden disease, has been reported. 2,[5][6][7] Cowden disease is an autosomal dominant disturbance characterized by multiple hamartomas and associated with a wide range of malignancies of the thyroid, skin, breast, intestine, and kidney. The exact correlation, nevertheless, is still uncertain.…”

“…1,5 Diagnosis is made through magnetic resonance imaging (MRI) and confirmed by histopathological exam. [1][2][3] We report the case of a 74-year-old patient, with sudden onset of symptoms, presenting this uncommon cerebellar lesion.…”

“…Lhermitte-Duclos disease (LDD), or cerebellar dysplastic gangliocytoma, is a rare type of cerebellar tumor of unknown origin. 1,2 The first report was documented in 1920. [2][3][4] Patients can be asymptomatic for several years, but there are usually imprecise neurological signs for long periods.…”

“…1,2 The first report was documented in 1920. [2][3][4] Patients can be asymptomatic for several years, but there are usually imprecise neurological signs for long periods. 1,5 Diagnosis is made through magnetic resonance imaging (MRI) and confirmed by histopathological exam.…”