Madelung’s disease is a rare condition characterised by the symmetric growth of fatty tumours (lipomas) around the neck, shoulders, upper arms, and trunk.We present a description of a male patient with extensive adipose tissue overgrowth around the neck. Once the possibility of malignancy was excluded, patient’s history, clinical and radiological findings suggest the diagnosis of MD. The two-stage surgery was established and the patient underwent the lipectomy of the lipomas around the neck. This article analyzed the clinical data with Madelung’s disease, discussed its aetiology, clinical manifestations, diagnosis, and treatment methods, and provided help for clinical diagnosis and treatment.